The Association of Silymarin, Vitamin C, Vitamin E, Coenzyme Q10 and Selenomethionine for the Treatment of Non Alcoholic Fatty Liver Disease

Romano, Adriana; Curcio, Annalisa; Nicola, Antonio Di; Grassi, Orazio; Schiaroli, Donatella; Nocera, Giuseppe Fabrizio; Pironti, Michele

doi:10.4172/2161-069x.1000589

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“…This study evaluated the efficacy and tolerability profile of the association of silymarin, vitamin C, vitamin E, coenzyme Q10 and selenomethionine (Medronys epato ® ) administered at dosage of 2 capsules a day in patients with NAFLD. This supplement has been formulated for a rapid hepatic recovery in chronic liver diseases of different etiology, by repristinating physiological functions of the hepatocytes, and consequently reducing liver enzymes levels and improving the lipid profile [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies demonstrated the efficacy of silymarin in NAFLD patients by the reduction of liver enzymes, serum biomarkers and ultrasonographic results [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several other substances with antioxidant and anti-inflammatory activity, like vitamin E, vitamin C, coenzyme Q10 and selenium, have been studied for their effect in the improvement of steatosis and liver enzymes in NAFLD patients, and showed their efficacy in the reduction of transaminases levels and in improving the fatty liver index. Often, these substances have been administered in combination with silymarin in order to improve its efficacy [ 16 , 17 , 19 , 20 , 23 , 24 , 25 , 26 ]. The formulation in study, made by the association of silymarin, vitamin C, vitamin E, coenzyme Q10 and selenomethionine (Medronys epato ® ), was designed to exploit the synergic effect of the single active ingredients added [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furtherly, significant results in the treatment of NAFLD have been reported in other studies, where active substances, like vitamin E, vitamin C, coenzyme Q10 and selenium, have been used in NAFLD patients for their antioxidant and anti-inflammatory proprieties. These compounds showed their effect on liver enzymes, inflammatory pathways and the improvement of health status of NAFLD patients, and have been in turn used in association with silymarin in order to improve its efficacy [ 16 , 17 , 19 , 20 , 23 , 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

“…A previous study showed the efficacy of the association of silymarin, vitamin C, vitamin E, coenzyme Q10 and selenomethionine in improving blood parameters (ALT, AST, ALP, GGT and ferritin), symptoms and ultrasonography in patients with NAFLD [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Silymarin in Combination with Vitamin C, Vitamin E, Coenzyme Q10 and Selenomethionine to Improve Liver Enzymes and Blood Lipid Profile in NAFLD Patients

Curcio¹,

Romano²,

Cuozzo³

et al. 2020

Medicina

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Background and Objectives: Non-Alcoholic Fatty Liver Disease (NAFLD) is an emerging cause of hepatopathy that is showing an increasing trend and where the recommendations of lifestyle modification are often not sufficient. The aim of this study is to evaluate the efficacy and tolerability profile of the association of silymarin, vitamin C, vitamin E, coenzyme Q10 and selenomethionine (Medronys epato®) by analyzing liver enzymes, along with the lipidic profile, as markers of liver function, and ultrasound results in NAFLD patients. Materials and Methods: This study enrolled 81 patients with mild to severe NAFLD, divided into two groups: Group A (N = 41) received two capsules a day of silymarin, vitamin C, vitamin E, coenzyme Q10 and selenomethionine (Medronys epato®), and Group B (N = 40) received only recommendations for lifestyle modification including hypocaloric diet, physical exercise and encouragement for weight loss. Patients have been evaluated at three timepoints: baseline (T0), after 45 days of treatment (T1) and after 90 days of treatment (T2), by collecting blood parameters of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT) and the lipid blood profile. Ultrasonographic results have been analyzed at T0 and T2, along with the tolerability profile and side effects, registered at time T2. Results: The administration of the association of silymarin, vitamin C, vitamin E, coenzyme Q10 and selenomethionine (Medronys epato®) was effective since it showed a significant reduction of the evaluated parameters of ALT, AST, ALP and GGT, a significant improvement of lipid parameters, evaluated as markers of liver function, and improvements of ultrasonographic results. The use of this formulation at the dosage of two capsules a day has been well tolerated and no adverse events have been reported during study period of three months. Conclusions: The administration of the association of silymarin, vitamin C, vitamin E, coenzyme Q10 and selenomethionine (Medronys epato®) was effective and well tolerated in the improvement of hepatic function of NAFLD patients.

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