The association of interdialytic blood pressure variability with cardiovascular events and all-cause mortality in haemodialysis patients

Sarafidis, Pantelis; Loutradis, Charalampos; Καρπέτας, Αντώνιος; Tzanis, Georgios; Bikos, Athanasios; Raptis, Vasileios; Syrgkanis, Christos; Liakopoulos, Vassilios; Papagianni, Αikaterini; Bakris, George L.; Parati, Gianfranco

doi:10.1093/ndt/gfy311

Cited by 11 publications

(20 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fluctuations of BP over the very short-term (beat-by-beat), short-term (within 24 hours), mid-term (day-by-day), and long-term (visit-to-visit) are associated with target-organ damage, cardiovascular events, and mortality in patients on HD. [38][39][40][41] However, whether BP variability is a modifiable risk factor or a marker of underlying pathology (e.g., volume shifts, arterial stiffness) remains uncertain. There are no studies of interventions targeting BP variability, so no treatment recommendations can be made, and further research is needed (Table 1).…”

Section: Bp Variabilitymentioning

confidence: 99%

Blood pressure and volume management in dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Flythe¹,

Chang²,

Gallagher³

et al. 2020

Kidney International

163

View full text Add to dashboard Cite

show abstract

Section: Bp Variabilitymentioning

confidence: 99%

Blood pressure and volume management in dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Flythe¹,

Chang²,

Gallagher³

et al. 2020

Kidney International

163

View full text Add to dashboard Cite

show abstract

“…One study presented overlapping data using the same datasets and was excluded [19]. Ultimately, the review included 15 eligible studies [18,[20][21][22][23][24][25][35][36][37][38][39][40][41][42]. Results from 2 studies did not provide sufficient data for the pooled analysis [22,42].…”

Section: Data Synthesis and Statistical Analysismentioning

confidence: 99%

“…Results from 2 studies did not provide sufficient data for the pooled analysis [22,42]. Thus a total of 13 studies were included in the meta-analyses [18,20,21,[23][24][25][35][36][37][38][39][40][41].…”

Section: Data Synthesis and Statistical Analysismentioning

confidence: 99%

“…6). One study reported a relationship between cardiovascular events and DBPV [18]. The HR was 1.35 (95% CI 1.02-1.79) with a 1-SD increase in DBPV for cardiovascular events.…”

Section: Association Between Diastolic Bpv and Outcomesmentioning

confidence: 99%

“…Studies have found an association between the mean BP and outcomes in patients on HD [15][16][17]. Over the last decade, more studies have explored the impact of BPV on the prognosis of HD patients, with inconsistent results [18][19][20][21][22][23][24][25]. Therefore, we conducted a systematic review and meta-analysis to assess the prognostic significance of BPV on cardiovascular and all-cause mortality and cardiovascular events in ESRD patients on dialysis.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Blood Pressure Variability and Outcomes in End-Stage Renal Disease Patients on Dialysis: A Systematic Review and Meta-Analysis

Xue

Dai

et al. 2020

Kidney Blood Press Res

View full text Add to dashboard Cite

Objective: Previous studies have suggested that blood pressure variability (BPV) is associated with an increased risk of mortality and cardiovascular events in patients on dialysis. However, the results are inconsistent. A comprehensive literature review was conducted to analyze the association between BPV and outcomes in patients on dialysis. Methods: Articles in Embase, Medline, and Web of Science from the date of inception through January 1, 2020, were identified. The outcomes were all-cause and cardiovascular mortality and cardiovascular events. The risk of bias was assessed using the Newcastle-Ottawa scale tool. Random effects models were used to pool the overall effect sizes. Two reviewers extracted the data independently. Meta-regression and subgroup analyses were performed to explore potential heterogeneity. Results: Fifteen eligible studies were included, and all enrolled hemodialysis recipients only. The overall risk of bias for the included studies was low. A 1-SD increase in systolic BPV was associated with higher risks of all-cause mortality (HR = 1.18; 95% CI 1.11–1.26, I2 = 53.8%), cardiovascular mortality (HR = 1.23; 95% CI 1.10–1.37, I2 = 57.2%), and cardiovascular events (HR = 1.27; 95% CI 1.07–1.51, I2 = 69.3%). Likewise, a 1-SD increase in diastolic BPV was associated with higher HR for all-cause and cardiovascular mortality (HR = 1.14; 95% CI 1.05–1.23, I2 = 0.0%, and HR = 1.14; 95% CI 0.94–1.38, I2 = 0.0%, respectively). Conclusions: A greater BPV is associated with higher risks of cardiovascular and mortality outcomes in patients on hemodialysis. Further research is required to determine whether BPV may be useful either as a marker enabling individualized treatment of cardiovascular risk or as a treatment target in its own right.

show abstract

Pulmonary hypertension and cardiovascular mortality in end-stage kidney disease: still some way to go before conclusive evidence

2021

View full text Add to dashboard Cite

The association of interdialytic blood pressure variability with cardiovascular events and all-cause mortality in haemodialysis patients

Cited by 11 publications

References 0 publications

Blood pressure and volume management in dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Blood pressure and volume management in dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Blood Pressure Variability and Outcomes in End-Stage Renal Disease Patients on Dialysis: A Systematic Review and Meta-Analysis

Pulmonary hypertension and cardiovascular mortality in end-stage kidney disease: still some way to go before conclusive evidence

Contact Info

Product

Resources

About