The association of Enamelin, Lactoferrin, and Tumour necrosis factor alpha gene polymorphisms with high caries susceptibility in Chinese children under 4 years old

Wang, Mengchen; Qin, Man; Xia, Bin

doi:10.1016/j.archoralbio.2017.03.023

Cited by 26 publications

(37 citation statements)

References 27 publications

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“…However, these results should be interpreted with caution due to small sample size (n = 30) and inclusion of subjects with DMFT = 1 in the carriesfree group [15]. The lack of association between LTF: c.140A>G polymorphism and the susceptibility to caries in deciduous dentition (the susceptibility to severe caries defined as DMFT index ≥4) has also been reported in children aged under 4 years (n = 1005) in China [17]. In addition, no significant association was previously found between LTF rs1126478 polymorphism and the severity of caries in Brazilian 12-year-old children (with comparison between children with DMFT ≤2 and children with DMFT ≥3) [8], in Czech children aged 11-13 years (comparison between children with DMFT = 1, children with vs. ≤2 DMFT ≤3 and children with DMFT ≥4) [16].…”

Section: Discussionmentioning

confidence: 89%

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A non-synonymous lactotransferrin gene polymorphism and dental caries in 12-year-old children from the West Pomeranian region in Poland

Rojek

Lewandowska

Boroń

et al. 2019

Pomeranian Journal of Life Sciences

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Introduction: Dental caries is an infectious disease affecting 60-90% of children around the world and therefore is the most common chronic disease in childhood. Lactotransferrin, encoded by LTF gene, is a salivary protein that limits microbial growth. The c.140A>G transition in the LTF gene (rs1126478), which results in a change from lysine (K) to arginine (R) at amino acid position 47 of lactotransferrin protein (p.K47R), significantly decreases bactericidal activity against Streptococcus mutans. Therefore, this raises the question of whether LTF: c.140A>G polymorphism is associated with risk of caries in Polish children with permanent dentition. Materials and methods: The rs1126478 LTF polymorphism was identified by sequencing genomic DNA isolated from buccal epithelial cells of 210 12-year-old children of European-descent from West Pomerania in Poland (59 rural children and 151 urban children). In the studied subjects, the decay-missing-filled teeth (DMFT) index ranged 0-14, and children with a DMFT value of 0 were treated as caries-free subjects (control group). Results: The caries frequency and mean DMFT in rural children were significantly higher than in urban children. Multiple logistic regression analysis, with adjustment for gender and place of permanent residence, revealed no significant association between LTF polymorphism and risk of caries. Conclusions: Our study shows that residence in rural areas, but not LTF c.140A>G polymorphism, is a risk factor for caries in 12-year-old children from West Pomerania.

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Section: Discussionmentioning

confidence: 89%

“…Results of a pilot genetic study revealed that "wild-type" LTF homozygotes (AA homozygotes) were less likely to have caries in permanent dentition [15]. However, other studies concerning the association between the LTF rs1126478 polymorphism and the risk of caries demonstrated conflicting results [8,16,17].…”

Section: Introductionmentioning

confidence: 99%

A non-synonymous lactotransferrin gene polymorphism and dental caries in 12-year-old children from the West Pomeranian region in Poland

Rojek

Lewandowska

Boroń

et al. 2019

Pomeranian Journal of Life Sciences

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“…Our previous report on the genotypic distribution of LTF rs1126478 in caries and caries‐free groups ( N = 1,005) suggested no positive association between this SNP and caries (Wang et al, ). To further investigate the impact of the LTF gene polymorphisms on different caries severity, we chose participants aged 24–48 months, and with complete primary dentition, from among our former study population, and grouped the patients according to whether they had moderate (8 ≤ dmft ≤ 12) or severe caries (13 ≤ dmft ≤ 20).…”

Section: Discussionmentioning

confidence: 94%

“…In addition, the AA genotype of rs1126478 displays bioactivities against other acid‐producing microbes (Velliyagounder et al, ) and regulates the formation of dental plaque biofilm, thus influencing caries status (Azevedo et al, ). However, previous studies showed inconsistent among different populations (Volckova et al, ; Wang, Qin, & Xia, ). LTF rs1126477 was proposed as a risk factor for periodontitis and might contribute to the immune response against periodontitis bacteria (Zupin et al, ).…”

Section: Introductionmentioning

confidence: 90%

Lack of association between LTF gene polymorphisms and different caries status in primary dentition

Wang

Qin

2018

Oral Diseases

Self Cite

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“…However, among these, certain risk factors (e.g., age and genetic factors) cannot be changed. According to a recent study, individuals boasting genetic polymorphism of certain genes such as enamelin (ENAM), mannose-binding lectin-2, and amelogenin X are more prone to experiencing this process [2,6,7]. Genetic polymorphism can be described as gene sequence variations between individuals that may or may not affect one's health.…”

Section: Introductionmentioning

confidence: 99%

Association of Enam C2452t Polymorphism With High Rates of Caries Occurrence in an Indonesian Population

Nicoline

Partakusuma

Joenoes³

et al. 2020

Int J App Pharm

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Objective: Tooth decay or the caries process is a common dental problem that affects millions of people worldwide. Many risk factors are modifiable,while others are not (e.g., genetic factors). Polymorphism of the enamelin (ENAM) gene, which is required to ensure production of an essentialprotein for enamel development, may pose as a risk factor for the caries process. This study sought to investigate the possibility of ENAM C2452Tpolymorphism acting as a risk factor in the caries process.Methods: The polymerase chain reaction–restriction fragment length polymorphism method was employed to evaluate DNA samples taken from 95subjects with a high caries prevalence and 89 control subjects for ENAM C2452T polymorphism.Results: Based on Chi-squared tests, there were significant genotype and allele distribution differences between the group with a high cariesprevalence and the control group (p=0.005 and p=0.007). Polymorphism in this context may, therefore, serve as a risk factor for caries onset andprogression (OR: 3.62).Conclusion: ENAM C2452T polymorphism is related to the caries process and may constitute a risk factor.

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The association of Enamelin, Lactoferrin, and Tumour necrosis factor alpha gene polymorphisms with high caries susceptibility in Chinese children under 4 years old

Cited by 26 publications

References 27 publications

A non-synonymous lactotransferrin gene polymorphism and dental caries in 12-year-old children from the West Pomeranian region in Poland

A non-synonymous lactotransferrin gene polymorphism and dental caries in 12-year-old children from the West Pomeranian region in Poland

Lack of association between LTF gene polymorphisms and different caries status in primary dentition

Association of Enam C2452t Polymorphism With High Rates of Caries Occurrence in an Indonesian Population

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