The association of circulating irisin with metabolic risk factors in Chinese adults: a cross-sectional community-based study

Tang, Lei; Tong, Yuzhen; Zhang, Fang; Chen, Guilin; Zhang, Yun Cong; Jobin, John; Tong, Nanwei

doi:10.21203/rs.2.13765/v1

Cited by 1 publication

(5 citation statements)

References 29 publications

(45 reference statements)

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“…In addition, it was shown that the serum irisin concentrations of individuals in the group with a diagnosis of MetS were higher compared to control group; this is attributed to the increased irisin resistance in adipose tissue (31). In the study of Tang et al, (16) a positive relationship was found between irisin and triglycerides; however, no relationship was found between total cholesterol and HDL-C and irisin.…”

Section: Irisinandmetabolic Syndromementioning

confidence: 84%

“…In studies conducted on individuals with T2DM (37) and gestational Diabetes Mellitus (38), it has been shown that serum irisin concentration was inversely related to the development of diabetes, considering that impairment of PGC-1α expression may result in this in individuals with T2DM. Fasting insulin, HOMA-IR were inversely associated with irisin concentration (16,39). Shoukry et al, (40) has found that serum irisin concentration was lower among individuals with new onset T2DM compared to healthy counterparts.…”

Section: Irisinandinsulin Resistancementioning

confidence: 97%

“…Studies showing an inverse relationship between adiposity and the concentration of circulating irisin have been reported in the literature (26,27). Tang et al, (16) have shown that the irisin concentration decreases in overweight and obese individuals compared to individuals with normal body weight. This is attributed to the impaired PGC-1α expression in muscle in obese individuals.…”

Section: Irisinandobesitymentioning

confidence: 99%

“…Shoukry et al, (40) has found that serum irisin concentration was lower among individuals with new onset T2DM compared to healthy counterparts. Therefore, modulation of the irisin level has pivotal role on controlling obesity and various diseases associated with obesity (16).…”

Section: Irisinandinsulin Resistancementioning

confidence: 99%

“…It serves on regeneration and function of beta cells in pancreas, maintains beta cell survival and increases secretion of some hormones including insulin and glucagon (Figure 1) (11). In addition, it is considered to be of great importance in terms of the cure of obesity and various diseases associated with obesity (16). The irisin molecule is thought to be a potential agent for use in the treatment of many diseases (17).…”

Section: Introductionmentioning

confidence: 99%

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An Overview of the Effects of Irisin on Metabolic Disorders

Berberoğlu

Hacışevki

2021

Gazi Sağlık Bilimleri Dergisi

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Obesity and obesity-related diseases including insulin resistance and metabolic syndrome (MetS) pose a great risk for cardiovascular disease development. Skeletal muscle as an endocrine organ has pivotal role on secreting physiological factors such as hormones and myokines. Irisin that is one of these myokines also known as hormone is secreted mainly from muscle tissue in response to exercise. It is dependent to fibronectin type III-containing protein 5 (FNDC5) that is a membrane protein and encoded by FNDC5 gene. After discovering of FNDC5, metabolic effects of irisin have been investigated so far. Irisin has mainly effects on muscle, adipose tissue, pancreas, liver, nervous system and bone. In studies conducted to date, obtained findings regarding the relationship of irisin status with obesity, insulin resistance and MetS are contradictory. Although irisin concentration was found higher in individuals with metabolic disorders in some studies, lower irisin concentration were observed in some other studies. Additionally, any receptors for irisin molecule hasn't yet discovered. Therefore, it is thought that the discovery of irisin molecule receptors and the determining of the tissues where these receptors are localized will be useful in understanding the mechanism of action of the irisin. In this review, we aimed to investigate potential effects of irisin on obesity, insulin resistance and MetS and additionally to examine underlying mechanisms of the association between circulating irisin and metabolic disorders.

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Section: Irisinandmetabolic Syndromementioning

confidence: 84%