The Association of Cardio-Ankle Vascular Index (CAVI) with Biatrial Remodeling in Atrial Fibrillation

Nakamura, Keijiro; Takagi, Takahito; Kogame, Norihiro; Hashimoto, H; Asami, Masatoshi; Toyoda, Yasutake; Enomoto, Yoshinari; Hara, Hidehiko; Noro, Mahito; Sugi, Kaoru; Moroi, Masao; Nakamura, Masato

doi:10.5551/jat.57737

Cited by 9 publications

(14 citation statements)

References 35 publications

(38 reference statements)

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“…Several studies have described that the arterial stiffness determined by the CAVI is related to atrial remodeling. 14,15 The reason is because an increased arterial stiffness and atrial remodeling share common risk factors, such as the age, DM, hypertension, dyslipidemia, and obesity, and an increased arterial stiffness induces elevations in the left ventricular filling pressure, which can result in atrial remodeling due to a chronic pressure overload. 16 Atrial remodeling has been defined as a persistent change in the atrial size or function.…”

Section: Main Findingsmentioning

confidence: 99%

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Predictive value of the cardio‐ankle vascular index for recurrence of atrial fibrillation after catheter ablation

Shinohara

Fujino

Wada

et al. 2021

Pacing Clinical Electrophis

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Background:The predictive value of the cardio-ankle vascular index (CAVI) for estimating the efficacy outcome of catheter ablation (CA) in atrial fibrillation (AF) patients is unclear. We aimed to examine the predictive performance of the CAVI for recurrences of atrial arrhythmias after CA. Methods:We enrolled a total of 193 patients with AF (paroxysmal 126 and nonparoxysmal 67) who underwent initial CA procedures at our institute, and CAVI measurements were conducted between January 2016 and March 2017. We evaluated recurrences of atrial arrhythmias after the first CA procedure as a clinical outcome.The CAVI value was assessed and the enrolled patients were divided according to the optimal CAVI value cut-off point (9.5) in the atrial arrhythmia recurrence group.Results: During a mean follow-up of 31.3 (17.5-43.0) months, 74 (32.5%; PaAF 41 and 49.3%; non-PaAF 33) patients had recurrences of atrial arrhythmias. The recurrence ratio of atrial arrhythmias was significantly higher in patients with a high CAVI (≥9.5) than those with a low CAVI (<9.5) (log rank test; p = 0.018). A univariate analysis showed the association between higher CAVI values and recurrences of atrial arrhythmias (p = 0.072). Multivariate analyses using a Cox proportional hazard model after adjusting for other clinical factors revealed that the CAVI value was determined to be a significant predictive factor of a recurrence of atrial arrhythmias after CA (Hazard ratio: 1.44, 95% confidence interval: 1.17-1.78, p < 0.01).

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Section: Main Findingsmentioning

confidence: 99%

“…However, Nakamura et al reported that there was a strong correlation between the CAVI values during AF and those during sinus rhythm. 14 Therefore, the reproducibility of the CAVI during AF might be relatively high and useful for evaluating the arterial stiffness even in patients with non-PaAF.…”

Section: Limitationsmentioning

confidence: 99%

Predictive value of the cardio‐ankle vascular index for recurrence of atrial fibrillation after catheter ablation

Shinohara

Fujino

Wada

et al. 2021

Pacing Clinical Electrophis

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show abstract

“…In this issue of the Journal of Atherosclerosis and Thrombosis, Nakamura et al examined the relationship between CAVI and atrial remodeling in association with AF in 213 consecutive patients with AF undergoing ablation 6) . Computed tomography was used to determine the atrial volume, and a threedimensional electromapping system was used to evaluate atrial electrical remodeling.…”

Section: See Article Vol 27: 000-000mentioning

confidence: 99%

“…The authors also noted several limitations of the study 6) . The observational nature precludes any causal inference.…”

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confidence: 98%

Cardio-Ankle Vascular Index and Atrial Remodeling for Atrial Fibrillation

Miyoshi

2021

JAT

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“…14 Several crosssectional studies have shown that CAVI reflects cardiac structural and functional changes associated with AF. 15,16 Furthermore, increased CAVI is significantly associated with AF prevalence even after adjusting CVD risks, 17 indicating the bidirectional interaction between systemic arterial stiffening and AF. However, the predictability of CAVI for the new-appearance of AF has not yet been explored, especially in general population receiving health screening.…”

Section: Introductionmentioning

confidence: 99%

Cardio-Ankle Vascular Index is Associated with Prevalence and New-Appearance of Atrial Fibrillation in Japanese Urban Residents: A Retrospective Cross-Sectional and Cohort Study

Nagayama¹,

Fujishiro²,

Nakamura³

et al. 2022

VHRM

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Physiological tests to assess systemic vascular function are not included in the risk score for atrial fibrillation (AF). We aimed to examine whether cardio-ankle vascular index (CAVI), a systemic arterial stiffness parameter, is associated with the presence of AF in Japanese general population. Methods: A cross-sectional study (N = 47,687) and a cohort study (N = 5418, four consecutive years) in Japanese urban residents who participated in annual health screening were conducted. Results: A total of 164 subjects (0.34%) had AF in the cross-sectional data. After propensity score matching for age and gender, logistic regression analysis revealed that CAVI is independently associated with AF, as are body mass index and estimated glomerular filtration rate. In a 4-year cohort study, 22 subjects (0.41%) with new-appearance of AF showed higher CAVI at baseline than those without. In the receiver-operating-characteristic curve analysis, the area under the curve, which is a measure of predictability, of CAVI for the new-appearance of AF was 0.747, and the cut-off value of CAVI was 8.0. Kaplan-Meier analysis revealed that the cumulative incidence of new-appearance of AF was higher in subjects with CAVI ≥8.0 compared to those with CAVI <8.0. In Cox-proportional hazards analysis, CAVI ≥8.0 as well as gender were identified as independent predictors for the new-appearance of AF, whereas age ≥65 years was not. Conclusion: Increased CAVI may represent a major modifiable risk factor for the development of AF. Studies are needed to confirm that CAVI is a predictor of AF independent of various AF risk factors and that CAVI-lowering interventions can prevent newappearance or recurrence of AF.

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The Association of Cardio-Ankle Vascular Index (CAVI) with Biatrial Remodeling in Atrial Fibrillation

Cited by 9 publications

References 35 publications

Predictive value of the cardio‐ankle vascular index for recurrence of atrial fibrillation after catheter ablation

Predictive value of the cardio‐ankle vascular index for recurrence of atrial fibrillation after catheter ablation

Cardio-Ankle Vascular Index and Atrial Remodeling for Atrial Fibrillation

Cardio-Ankle Vascular Index is Associated with Prevalence and New-Appearance of Atrial Fibrillation in Japanese Urban Residents: A Retrospective Cross-Sectional and Cohort Study

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