The association of cadmium and lead exposures with red cell distribution width

Peters, Junenette L.; Perry, Melissa J.; McNeely, Eileen; Wright, Robert O.; Heiger-Bernays, Wendy; Weuve, Jennifer

doi:10.1371/journal.pone.0245173

Cited by 22 publications

(25 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other chemical exposures may also be associated with reduced humoral responses to vaccines and could be analyzed using the NHANES dataset. 75 Several studies have documented associations in humans between a few chemicals or single chemical families and immune measure outcomes 40,59,[76][77][78][79][80] , but there has not been a broad analysis of environmental chemical exposures and immune measures in the US. Our results were based on a large, diverse, and nationally representative subset of 68,160 participants from NHANES.…”

Section: Discussionmentioning

confidence: 99%

“…32,38 Future studies may investigate the association between environmental chemicals and MCV, adjusting for intake of iron, folate, vitamin B12, and other dietary vitamins and minerals. 39,40 Associations between MCV and environmental chemicals outside of heavy metals have been under-studied and could be a new and interesting direction for research.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Environmental chemical-wide associations with immune biomarkers in the US: A cross-sectional analysis

Middleton

Nguyen

Dou

et al. 2022

Preprint

View full text Add to dashboard Cite

Exposure to environmental chemicals influence immune system functions, and humans are exposed to a wide range of chemicals, termed the chemical exposome. Thus, a comprehensive analysis of the effects across multiple chemical families with immune biomarkers is needed. In this study, we tested the associations between environmental chemicals and immune biomarkers. We analyzed the United States cross-sectional National Health and Nutrition Examination Survey (NHANES 1999-2018). Chemicals were measured in blood or urine (198 chemicals, 17 families). Immune biomarkers included percentages of lymphocytes, neutrophils, monocytes, basophils, and eosinophils, and counts of red blood cells, white blood cells, and mean corpuscular volume. We conducted survey-weighted, multivariable linear regressions of log2-transformed chemicals on immune measures, adjusted for age, sex, race/ethnicity, poverty-income ratio, waist circumference, cotinine concentration, creatinine for urinary chemicals, and survey cycle. We accounted for multiple comparisons using a false discovery rate (FDR). Among 45,528 adult participants, using survey weights, the mean age was 45.7 years, 51.4% were female, and 69.3% were Non-Hispanic White. There were 65 chemicals associated with white blood cell count. For example, a doubling in the concentration of blood lead was associated with a decrease of 61 white blood cells per μL (95% CI: 23-99; FDR=0.005). 122 (61.6%) chemicals were associated with at least one of the eight immune biomarkers. Chemicals in the Metals family were associated with all eight immune measures. Concentrations of a wide variety of biomarkers of exposure to chemicals such as metals and smoking-related compounds, were highly associated with immune system biomarkers, with implications for immune function and toxicology. This environmental chemical-wide association study identified chemicals from multiple families for further toxicological and epidemiological investigation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Environmental chemical-wide associations with immune biomarkers in the US: A cross-sectional analysis

Middleton

Nguyen

Dou

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Adolescents may be exposed to multiple metals simultaneously through dietary or environmental sources, such as air emissions, consumer products, and contaminated drinking water (Agency for Toxic Substances and Disease Registry, 1999, 2003, 2012b, 2012a, 2020). Further, environmental metals tend to operate on similar mechanistic pathways, including reducing Fe absorption, altering heme synthesis, and disrupting erythropoietin production (McCann et al., 2020; Peters et al., 2021; Rossander‐Hultén et al., 1991), which supports the potential for metal‐metal interactions or cumulative effects. Therefore, further research is warranted to identify associations of metal mixtures with Fe status in U.S. adolescents.…”

Section: Introductionmentioning

confidence: 89%

Associations of a metal mixture with iron status in U.S. adolescents: Evidence from the National Health and Nutrition Examination Survey

Schildroth

Friedman

Bauer

et al. 2022

New Drctns Chld & Adlscnt

View full text Add to dashboard Cite

Iron is needed for normal development in adolescence. Exposure to individual environmental metals (e.g., lead) has been associated with altered iron status in adolescence, but little is known about the cumulative associations of multiple metals with Fe status. We used data from the 2017-2018 National Health and Nutrition Examination Survey (NHANES) to examine associations between a metal mixture (lead, manganese, cadmium, selenium) and iron status in 588 U.S. adolescents (12-17 years). We estimated cumulative and interactive associations of the metal mixture with five iron status metrics using Bayesian Kernel Machine Regression (BKMR). Higher concentrations of manganese and cadmium were associated with lower log-transformed ferritin concentrations. Interactions were observed between manganese, cadmium, and lead for ferritin and the transferrin receptor, where iron status tended to be worse at higher concentrations of all metals. These results may reflect competition between environmental metals and iron for cellular uptake. Mixed metal exposures may alter normal iron function, which has implications for adolescent development.

show abstract

“…Another recent study indicated that blood lead concentrations were associated with increased odds of high RDW, and these associations were more pronounced in women and those with low-to-normal MCV [9]. Moreover, lead poisoning patients have been frequently shown to display hypochromic microcytic anemia -a type of anemia in which the red blood cells (RBCs) are smaller and paler than normal, with a reduced amount of hemoglobin [10].…”

Section: Introductionmentioning

confidence: 99%

Poisoned in Their Homes- Red Blood Cell Abnormalities in Lead-Exposed Residents of a Pakistani Industrial Zone

Shah

Shoaib

Iqbal

et al. 2023

Preprint

View full text Add to dashboard Cite

The present study investigated the clinical and hematological effects of chronic lead exposure in the population residing in Shadi Pura, a small industrial zone in Lahore, Pakistan. A cross-sectional analysis of 149 participants recruited through health camps was conducted to explore the hematological manifestations of environmental lead exposure, focusing on various red blood cell (RBC) indices and morphology. Moreover, the study examined the differences in the impact of lead exposure on RBC indices and morphology between men, women, and children. Participants exhibited symptoms of lead poisoning, including fatigue, muscle pain, and headache, with a significant percentage of women (44%) reporting miscarriages. Iron deficiency anemia was highly prevalent among all sub-groups of the study population, with adult females showing a significantly higher prevalence than adult males. Male children were the most affected subgroup, with 93% displaying anemia. The RBC count in children remained unchanged, while 31% of male and 7% of female participants displayed elevated RBC counts. RBC indices, mainly mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH), were below normal levels, with children being more affected than adults and adult males being the least affected group. Furthermore, RBC morphology was severely affected, with a considerable proportion of females and children displaying hypochromic microcytic morphology. Our results highlight variations in the hematological impacts of lead exposure in different gender and age cohorts. Overall our findings underscore the urgency of addressing the issue of environmental lead exposure in similar industrial zones. It is critical to implement appropriate measures to reduce lead exposure and enhance the infrastructure for safe drinking water and waste disposal to protect the health of populations in such areas.

show abstract

The association of cadmium and lead exposures with red cell distribution width

Cited by 22 publications

References 65 publications

Environmental chemical-wide associations with immune biomarkers in the US: A cross-sectional analysis

Environmental chemical-wide associations with immune biomarkers in the US: A cross-sectional analysis

Associations of a metal mixture with iron status in U.S. adolescents: Evidence from the National Health and Nutrition Examination Survey

Poisoned in Their Homes- Red Blood Cell Abnormalities in Lead-Exposed Residents of a Pakistani Industrial Zone

Contact Info

Product

Resources

About