The Association Between the Survivin C-31G Polymorphism and Gastric Cancer Risk in a Chinese Population

Yang, Li; Zhu, Hao; Zhou, Bo; Gu, Hongru; Yan, Hongli; Tang, Naping; Hua, Dong; Sun, Qingmin; Cong, Rihong; Chen, Guoyu; Wang, Bin

doi:10.1007/s10620-008-0441-5

Cited by 41 publications

(45 citation statements)

References 34 publications

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“…Similar to other malignancies, the mechanism of gastric carcinogenesis involves a complex multi-stage and multi-factorial process that depends on gene-environment interactions (4). In previous epidemiological studies, genetic factors were demonstrated to play an important role in the development of gastric cancer (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Association between LMP2 and LMP7 gene polymorphisms and the risk of gastric cancer: A case-control study

Yang

Tang

et al. 2015

Oncol Lett

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Abstract. The integrality of low molecular weight protein (LMP)2/LMP7 function plays an important role in the processing of GC cell antigens. The purpose of the present hospital-based case-control study was to estimate the effect of polymorphisms in the LMP2 and LMP7 genes on the risk of GC. Polymerase chain reaction-restriction fragment length polymorphism analysis was used to distinguish the Arg to His substitution at codon 60 of LMP2 (LMP2-60) and the Gln to Lys substitution at codon 145 of LMP7 (LMP7-145) in 502 gastric cancer patients and 502 age and gender-matched cancer-free control individuals. The Lys allele of the LMP7-145 variant was more frequent in GC patients compared with control individuals [P=0.004; adjusted odds ratio (OR), 1.39; 95% confidence interval (CI), 1.11-1.74]. The Gln/Lys and Lys/Lys genotypes increased the risk of GC compared with the Gln/Gln genotype (P=0.049 and P=0.041, respectively; adjusted OR, 1.32 and 2.13, respectively; 95% CI, 1.00-1.73 and 1.03-4.39, respectively). Compared with the Gln/Gln genotype, the LMP7-145 Gln/Lys and Lys/Lys variants of the LMP7 gene were also associated with increased susceptibility to GC (P=0.017; adjusted OR, 1.38; 95% CI, 1.06-1.80). Haplotype analysis revealed that the LMP2 (Arg)-LMP7 (Lys) haplotype was associated with increased risk of GC (P=0.013, adjusted OR=1.34, 95% CI=1.06-1.70). Stratified analysis revealed that the association between the risk of GC and the variant genotypes of LMP7-145 was stronger in older individuals (>59 years), males and non-smokers. However, no association between the LMP2-60 polymorphism and the risk of GC was observed. The present results suggest that the LMP7-145 genetic variant contributes to increased susceptibility to GC, and the Lys allele is an independent risk factor for GC.

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Section: Introductionmentioning

confidence: 99%

Association between LMP2 and LMP7 gene polymorphisms and the risk of gastric cancer: A case-control study

Yang

Tang

et al. 2015

Oncol Lett

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“…Clarification of the survivin signaling pathway will provide new predictive and prognostic information for cancer diagnosis and could lead to the development of new therapeutic alternatives for a variety of cancers (Altieri, 2001;Yamamoto and Tanigawa, 2001). High survivin expression has been detected in several cancer types in humans, including colorectal cancer, hepatocellular cancer, lung cancer, pancreatic cancer, and osteosarcoma (Wang et al, 2009;Yang et al, 2009;Theodoropoulos et al, 2010;Upadhyay et al, 2011; Borges et al, 2011;Srivastava et al, 2012). Survivin is also expressed in breast cancer (Yamashita et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Yang et al (2009) reported that the C allele increased the risk of developing esophageal squamous cell carcinoma, and Wang et al (2009) reported that the risk of developing urothelial carcinoma was significantly greater in individuals with the GC + CC genotype than in individuals with the GG genotype. Consistent with the studies by Yang et al (2009) and Wang et al (2009), we found that the risk of developing breast cancer was significantly greater (by 1.413 times; 95% CI: 1.040-1.918) in individuals with the GC or CC genotype than in individuals with the GG genotype. Bayram et al (2011) studied the association between the -31G > C polymorphism and hepatocellular carcinoma in a Turkish population, but found no difference in the genotype distributions of patients with hepatocellular carcinoma and cancer-free individuals.…”

Section: Discussionmentioning

confidence: 99%

“…The G > C mutation correlates with the increased expression of survivin at both the transcriptional and translational levels (Yazdani et al, 2012). Several case-control studies have examined the association between the -31G > C polymorphism and the risk of cancer (Srivastava et al, 2012), including nasopharyngeal carcinoma (Yang et al, 2009), esophageal cancer (Upadhyay et al, 2011), gastric cancer (Yang et al, 2009;Borges et al, 2011), hepatocellular carcinoma (Bayram et al, 2011), pancreatic cancer (Theodoropoulos et al, 2010), and urothelial carcinoma (Wang et al, 2009), but the results are controversial.…”

Section: Introductionmentioning

confidence: 99%

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The effect of survivin gene promoter polymorphism on breast cancer

Altiparmak¹,

Bilgiç²,

Dener³

et al. 2014

Turk J Biol

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Breast cancer is the most common malignant tumor in women and accounts for about 25% of all cancer diagnoses. Survivin is a member of the apoptosis inhibitor protein family of antiapoptotic proteins. In our study, we investigated one of those, the survivin gene promoter 31G/C polymorphism. Included in this study were 111 breast cancer patients who were operated on in our hospital and 101 healthy female subjects. Blood samples from the healthy subjects and paraffin-embedded tissue samples from the patients were used for DNA extraction and subsequent genetic analysis. PCR-RFLP was used for genotype analysis. We established the clinicopathologic characteristics of patients. No significant difference was found between survivin 31G/C promoter polymorphism of tumor characteristics and breast cancer. Between the control and breast cancer groups, survivin promoter polymorphism 31G/C differences were not significantly different (P = 0.058). The risk of developing cancer, having the relevant GC or CC genotype, is 1.413 times higher than those having genotype GG (95% confidence interval: 1.040 to 1.918). Carrying the C allele was statistically significant in terms of susceptibility to breast cancer. In conclusion, the use of survivin gene polymorphism as a risk factor in breast cancer is recommended based on the results of this study.

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“…12 Following this finding, researchers used in vitro promoter assays to demonstrate that the À31G allele had significantly lower transcriptional activity than the À31C allele, suggesting that the À31G/C polymorphism influences survivin expression, thus contributing to the genetic susceptibility to lung cancer. 13 Recently, many studies have investigated the role of the survivin À31G4C polymorphism in the etiology of various type of cancers, [13][14][15][16][17][18][19][20][21][22][23][24][25] including lung, gastric, bladder, esophageal, colorectal, urothelial, and pancreatic cancer. However, the results of these studies remain inconclusive.…”

Section: Introductionmentioning

confidence: 99%

Association between survivin −31G>C promoter polymorphism and cancer risk: a meta-analysis

Wang

Huang

et al. 2012

Eur J Hum Genet

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Survivin is an inhibitor of apoptosis protein and has a crucial role in the development of cancer. The survivin À31G4C (rs9904341) promoter polymorphism influences survivin expression and has been implicated in cancer risk. However, conflicting results have been published from studies on the association between survivin À31G4C polymorphism and the risk of cancer. To clarify the role of this polymorphism in cancer, we performed a meta-analysis of all available and relevant published studies, involving a total of 3485 cancer patients and 3964 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations. The overall results indicated that the variant genotypes were associated with a significantly increased cancer risk (CC vs GG: OR¼1.58, 95% CI¼1.20-2.10; CC/GC vs GG: OR¼1.23, 95% CI¼1.00-1.51; CC vs GG/GC: OR¼1.51, 95% CI¼1.23-1.85). In the stratified analyses, significantly increased risk was associated with the Asian populations (CC vs GG: OR¼1.67, 95% CI¼1.16-2.40; CC vs GG/GC: OR¼1.50, 95% CI¼1.17-1.91). We also performed the analyses by cancer type, and no statistical association was observed. The results suggest that the survivin À31G4C promoter polymorphism might be associated with an increased risk of cancer, especially in the Asian populations.

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The Association Between the Survivin C-31G Polymorphism and Gastric Cancer Risk in a Chinese Population

Abstract: Our results demonstrate that the survivin C-31G polymorphism may be involved in distal gastric carcinogenesis and tumor differentiation in a Chinese population.

Cited by 41 publications

References 34 publications

Association between LMP2 and LMP7 gene polymorphisms and the risk of gastric cancer: A case-control study

Association between LMP2 and LMP7 gene polymorphisms and the risk of gastric cancer: A case-control study

The effect of survivin gene promoter polymorphism on breast cancer

Association between survivin −31G>C promoter polymorphism and cancer risk: a meta-analysis

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