The Association between Platelet/Lymphocyte Ratio and Coronary Artery Disease Severity in Asymptomatic Low Ejection Fraction Patients

Uçar, Fatih Mehmet; Açar, Burak; Gül, Murat; Özeke, Özcan; Aydoğdu, Sinan

doi:10.4070/kcj.2016.46.6.821

Cited by 22 publications

(27 citation statements)

References 25 publications

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“…We have found that NLR was a more useful marker at ROC curve, similar to studies in HF. 28,29 Besides, in our study, NLR-but not PLR-was independently associated with 1 year mortality on multivariate analysis, in accordance with one study in HF. 28 Moreover, NLR was also associated with increased in-hospital mortality.…”

Section: Discussionsupporting

confidence: 91%

“…Although both markers have shown prognostic value in several cardiac conditions, few studies have compared them. We have found that NLR was a more useful marker at ROC curve, similar to studies in HF 28, 29. Besides, in our study, NLR—but not PLR—was independently associated with 1 year mortality on multivariate analysis, in accordance with one study in HF 28.…”

Section: Discussionsupporting

confidence: 91%

“…NLR AUC in our study in HTX showed better performance for in‐hospital mortality compared with the AUC for predicting major adverse cardiovascular events after percutaneous coronary interventions,26 or saphenous vein graft disease,27 and atrial fibrillation20 after CABG. On the contrary, other studies have showed better NLR AUC for mortality both in HF28, 29 and in non‐ST elevation myocardial infarction 30. The results for PLR were different, and most studies have showed a better predictive value in ST elevation myocardial infarction,13, 14, 15 HF,28, 29 and transcatheter aortic valve replacement,21 and after percutaneous coronary interventions26 or after implantable cardioverter defibrillator placement 18.…”

Section: Discussionmentioning

confidence: 98%

“…On the contrary, other studies have showed better NLR AUC for mortality both in HF28, 29 and in non‐ST elevation myocardial infarction 30. The results for PLR were different, and most studies have showed a better predictive value in ST elevation myocardial infarction,13, 14, 15 HF,28, 29 and transcatheter aortic valve replacement,21 and after percutaneous coronary interventions26 or after implantable cardioverter defibrillator placement 18. Of note, only few studies analysed the predictive value of PLR for mortality, and most showed predictive value in surrogate endpoints.…”

Section: Discussionmentioning

confidence: 98%

“…First described in 1967 as an indicator of ozone exposure, 10 NLR has shown prognostic value in different cardiovascular conditions including stable coronary artery disease, acute coronary syndromes, HF, and coronary artery bypass grafting (CABG). 11 On the other hand, platelet-to-lymphocyte ratio (PLR) was first described in 2008 as a prognostic marker in periampullary cancer 12 and has also shown prognostic value in patients with ST elevation acute myocardial infarction [13][14][15] and stable coronary artery disease 16,17 and in patients with an implantable cardioverter defibrillator. 18 Despite raising evidence supporting the use of NLR and PLR in cardiovascular disease, no study has evaluated the role of these markers in patients undergoing HTX.…”

Section: Introductionmentioning

confidence: 99%

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Neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio as predictors of survival after heart transplantation

et al. 2017

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AimsThe aim of this study was to evaluate whether neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR) predict outcome in heart failure (HF) patients undergoing heart transplantation (HTX).Methods and resultsData from 111 HF patients undergoing HTX 2010–2015 were retrospectively reviewed. NLR and PLR were calculated before HTX, immediately after HTX, and at 6 and 24 hours. Primary endpoint was in‐hospital mortality, and secondary endpoints were 1 year mortality and renal replacement therapy (RRT). Prognostic factors were assessed by multivariate analysis, and the predictive values of NLR and PLR for mortality were compared. The discriminatory performance for predicting in‐hospital mortality was better for NLR [area under the receiver operating characteristic curve (AUC) = 0.644, 95% confidence interval 0.492–0.797] than for PLR (AUC = 0.599, 95% confidence interval 0.423–0.776). Best cut‐off value was 2.41 for NLR (sensitivity 86%, specificity 67%) and 92.5 for PLR (sensitivity 86%, specificity 68%). When divided according to best cut‐off value, in‐hospital mortality was significantly higher in the high NLR group (17.5% vs. 3.2%, P < 0.05), but not in the high PLR group (16.5% vs. 6.3%, P = ns). One year mortality was not significantly higher for either group (37.5% vs. 6.5% for NLR; 36.7% vs. 9.4% for PLR, P = ns for both), while RRT was significantly higher in both the NLR and PLR high groups (33.8% vs. 0%; 32.9% vs. 3.1%, respectively, P < 0.001). Multivariate analysis indicated that only high NLR (hazard ratio = 3.403, P < 0.05) and pre‐transplant diabetes (hazard ratio = 3.364, P < 0.05) were independent prognostic factors for 1 year mortality.ConclusionsHigh NLR was a predictor for in‐hospital mortality, and an independent prognostic factor for 1 year mortality. Both high NLR and high PLR were predictors for RRT.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio as predictors of survival after heart transplantation

et al. 2017

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The impact of platelet indices on clinical outcome in heart failure: results from the MyoVasc study

et al. 2021

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Aims Platelet indices have been associated with traditional cardiovascular risk factors, cardiovascular diseases and all-cause mortality. This study aimed to investigate the role of platelet count, mean platelet volume (MPV) and platelet-to-leukocyte ratio, including platelet-to-monocyte and platelet-to-lymphocyte ratio with cardiac function, heart failure (HF) phenotypes and clinical outcome, worsening of HF. Methods and results Univariate and multivariable linear and Cox regression analyses were used to investigate the associations between platelet indices, cardiac function and worsening of HF in 3250 subjects enrolled in the MyoVasc study. Higher MPV, lower platelet count, lower platelet-to-leukocyte and platelet-to-monocyte ratios have been associated with reduced left ventricular ejection fraction (beta estimate [β] MPV [fL] = À0.05 [À0.09; À0.02], β platelet count (× 10/L) 9 = 3.4 [1.2; 5.6], β platelet-to-leukocyte ratio = 1.4 [1.1; 1.8], β platelet-to-monocyte ratio = 28 [20; 36]) and increased E/E' ratio (β MPV [fL] = 0.04 [0.003; 0.07], β platelet count (× 10/L) 9 = À3.1 [À5.3; À0.92], β platelet-to-leukocyte ratio = À0.83 [À1.2; À0.46], β platelet-to-monocyte ratio = À20 [À28; À12]), independent of age and sex. Cox regression demonstrated an increased risk for worsening of HF in subjects with MPV > 75th percentile (hazard ratio [HR] = 1.47 [1.16; 1.87]), platelet count < 25th percentile (HR = 1.36 [1.07; 1.74]), platelet-to-leukocyte < 25th percentile (HR = 1.53 [1.20; 1.95]), platelet-to-monocyte < 25th percentile (HR = 1.38 [1.08; 1.77]) and platelet-to-lymphocyte > 75th percentile (HR = 1.50 [1.17; 1.93]) ratios, independent of potential confounders. MPV > 75th percentile and platelet count < 25th percentile were strongly related to outcome in HFpEF vs. HFrEF (P for difference = 0.040). Platelet-to-leukocyte ratios were associated with worse outcome in both HF phenotypes, without a significant difference between HFpEF and HFrEF. Conclusions Platelet indices are linked with worse cardiac function and adverse clinical outcome, independent of subjects' underlying cardiovascular profile. This study emphasizes their important value to provide additional information on pathophysiology and risk stratification in HF syndrome.

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Primary graft dysfunction after heart transplantation: a thorn amongst the roses

et al. 2019

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Primary graft dysfunction (PGD) remains the leading cause of early mortality post-heart transplantation. Despite improvements in mechanical circulatory support and critical care measures, the rate of PGD remains significant. A recent consensus statement by the International Society of Heart and Lung Transplantation (ISHLT) has formulated a definition for PGD. Five years on, we look at current concepts and future directions of PGD in the current era of transplantation.

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The Association between Platelet/Lymphocyte Ratio and Coronary Artery Disease Severity in Asymptomatic Low Ejection Fraction Patients

Cited by 22 publications

References 25 publications

Neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio as predictors of survival after heart transplantation

Neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio as predictors of survival after heart transplantation

The impact of platelet indices on clinical outcome in heart failure: results from the MyoVasc study

Primary graft dysfunction after heart transplantation: a thorn amongst the roses

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