The association between mean platelet volume and cardiovascular risk factors

Sansanayudh, Nakarin; Muntham, Dittapol; Yamwong, Sukit; Sritara, Piyamitr; Akrawichien, Tawatchai; Thakkinstian, Ammarin

doi:10.1016/j.ejim.2015.11.028

Cited by 39 publications

(20 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Sleep disturbance and desynchronization between endogenous rhythm and behavioral cycles are common among elderly people and represent important health issues for their relationship with an adverse metabolic profile, and a proinflammatory condition which can increase the risk of CV disease and early mortality. Although the mechanisms underlying these associations are not fully understood, data in younger age classes have evidenced the role of systemic inflammation through increases in WBC count, confirmed in our Mugello population [33,34]. If further studies will confirm this relationship also in the oldest old, approaches to lower disease risk associated with increased sleep-related inflammation should be evaluated in this particular population.…”

Section: Sleepsupporting

confidence: 56%

Relationship between Inflammatory Parameters and Cardiovascular and Lifestyle Factors in the Mugello Study Oldest Old

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Sleepsupporting

confidence: 56%

Relationship between Inflammatory Parameters and Cardiovascular and Lifestyle Factors in the Mugello Study Oldest Old

et al. 2018

View full text Add to dashboard Cite

show abstract

“…High-volume thrombocytes are metabolically and enzymatically more active than small-volume thrombocytes, and they are thought to have a higher hemostasis capacity. Studies conducted on this subject have reported that CDV are seen more in patients with high MPV, and there is a greater possibility of the development of CDV in healthy individuals with high MPV (13,30). In a recent study, it was reported that patients with MPV values >10.4 were a risk group for the development of atherosclerosis even if there was no previous cardiovascular pathology on angiography (13).…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have suggested that MPV is a potential biomarker for CDV (13,30). High-volume thrombocytes are metabolically and enzymatically more active than small-volume thrombocytes, and they are thought to have a higher hemostasis capacity.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of laparoscopic sleeve gastrectomy on atherosclerotic and hemocytic parameters in obese patients

et al. 2018

View full text Add to dashboard Cite

Objectives:The aim of this study was to evaluate the effects of the change in the body mass index following laparoscopic sleeve gastrectomy on the vascular morphology structure and biochemical and hemocytic parameters. Material and Methods:A prospective evaluation of 60 patients who underwent sleeve gastrectomy was conducted. The relationship was evaluated between the vascular morphological parameters and biochemical and hemocytic inflammatory variables of the patients preoperatively and at 6, 12, and 18 months postoperatively.Results: Compared to the baseline values, a significant decrease was determined in the carotid intima media thickness at 6, 12, and 18 months (p<0.001, p<0.001, p<0.001, respectively). The compliance and distensibility values were observed to increase over time (p<0.05, p<0.001, p<0.001, respectively). A statistically significant difference was determined in the carotid intima media thickness values according to gender, with males (n:7) measuring 0.618±0.123 mm and females (n:53) measuring 0.506±0.113 mm (p<0.01). When patients were grouped as neutrophil-to-lymphocyte ratio ≤2.54 (n:41) and neutrophil-to-lymphocyte ratio>2.55 (n:19), the increasing neutrophil-to-lymphocyte ratio values were observed to be in proportion to the carotid intima media thickness, and the difference was statistically significant (p<0.001). When factors affecting the vascular morphology parameters measured at baseline and throughout the study were evaluated with the correlation analysis, there was observed to be a positive correlation between the baseline carotid intima media thickness thickness and neutrophil percentage (r=0.736, p<0.001) and neutrophil-to-lymphocyte ratio (r=0.676, p<0.001), and between the negative correlation and lymphocyte percentage (r=−0.628, p<0.001). Conclusion:Laparoscopic sleeve gastrectomy is not only a cosmetic procedure reducing the body mass index values, but it also has a beneficiary effect on vascular morphology, biochemical, and hemocytic parameters.

show abstract

“…The exact mechanism of NVG secondary to RVO or DR is multifactorial and remains unknown. It has been shown that platelets play an important role in the pathophysiology of retinal artery occlusion [27], nonarteritic anterior ischemic optic neuropathy [6], ischemic and hemorrhagic stroke [7], and cardiovascular diseases [28]. In this study, 38 patients with NVG secondary to RVO and 47 patients with NVG secondary to DR were studied with regard to platelet parameters and compared to control subjects.…”

Section: Discussionmentioning

confidence: 99%

Role of Platelet Parameters on Neovascular Glaucoma: A Retrospective Case-Control Study in China

Cao

Sun

2016

PLoS ONE

View full text Add to dashboard Cite

PurposeRetinal vein occlusion (RVO) and diabetic retinopathy (DR) are two major sight-threatening diseases which may lead to neovascular glaucoma (NVG). The aim of this study was to explore the association between platelet parameters and NVG.MethodsA total of 185 subjects were enrolled for the study from January, 2012 to December, 2015 at the Eye-ENT Hospital of Fudan University. Patients include those with NVG secondary to RVO (RVO group, n = 38), patients with NVG secondary to DR (DR group, n = 47), diabetics mellitus without retinopathy (DM group, n = 52), and healthy individuals (control group, n = 48). A complete ophthalmological examination including visual field examination, A-scan ultrasound, Fundus photography, and measurement of platelet parameters were performed for NVG subjects.ResultsThere was no statistical difference in the mean age and gender among the RVO, DR, and control groups (p>0.05). The mean level of platelet distribution width (PDW) was higher (p<0.001) in the RVO group (15.16±2.13fl) and DR group (16.17±1.66fl) when compared with the control group (13.77±2.99fl). The mean plateletcrit (PCT) value of the RVO group (0.229±0.063%) was also higher (p = 0.049) than the control group (0.199±0.045). In the DR group, mean platelet volume (MPV) value (10.72±1.57fl) was significantly higher (p = 0.002) than the control group (9.75±0.89fl). A similar trend was observed when platelet parameters were compared among the 3 groups with respect to age. The mean level of PDW was significantly higher (p<0.001) in the DR group (16.17±1.66fl) compared with the DM group (13.80±3.32fl). Stepwise multiple logistic regression analysis revealed that PDW (OR = 1.44, 95%CI = 1.149–1.805, p = 0.002) and MPV (OR = 1.503, 95%CI = 1.031–2.192, p = 0.034) were associated with the DR group, PDW (OR = 1.207, 95%CI = 1.010–1.443, p = 0.039) and PCT (OR = 1.663, 95%CI = 1.870–2.654, p = 0.036) were associated with the RVO group.ConclusionOur results suggest that increased PDW and MPV are associated with the NVG secondary to DR group, elevated PDW and PCT are associated with the RVO group. It indicates that platelets might be an important factor in the onset and/or development of NVG.

show abstract

The association between mean platelet volume and cardiovascular risk factors

Cited by 39 publications

References 35 publications

Relationship between Inflammatory Parameters and Cardiovascular and Lifestyle Factors in the Mugello Study Oldest Old

Relationship between Inflammatory Parameters and Cardiovascular and Lifestyle Factors in the Mugello Study Oldest Old

Protective effects of laparoscopic sleeve gastrectomy on atherosclerotic and hemocytic parameters in obese patients

Role of Platelet Parameters on Neovascular Glaucoma: A Retrospective Case-Control Study in China

Contact Info

Product

Resources

About