The association between manganese exposure with cardiovascular disease in older adults: NHANES 2011–2018

Xiao, Shengjue; Zhou, Yufei; Liu, Tao; Hu, Yue; Wu, Qi; Pan, Qinyuan; Wang, Xiaotong; Liu, Ailin; Liu, Jie; Zhu, Hong; Yin, Ting; Pan, Defeng

doi:10.1080/10934529.2021.1973823

Cited by 10 publications

(7 citation statements)

References 22 publications

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“…Not only does manganese play an important role in many biological functions, 7 but also the key component of manganese‐dependent enzymes in the body 8 . Besides, Mn is strongly associated with risks of many NCDs including cardiovascular disease, dyslipidemia, chronic kidney disease and diabetes 8–12 . However, as a potential toxicant, overexposure to manganese can also be dangerous because of its neurotoxicity, reproductive toxicity, and cardiovascular toxicity 13,14 .…”

Section: Introductionmentioning

confidence: 99%

“…8 Besides, Mn is strongly associated with risks of many NCDs including cardiovascular disease, dyslipidemia, chronic kidney disease and diabetes. [8][9][10][11][12] However, as a potential toxicant, overexposure to manganese can also be dangerous because of its neurotoxicity, reproductive toxicity, and cardiovascular toxicity. 13,14 Additionally, excessive manganese can result in higher oxidative stress and inflammation levels by disrupting the antioxidative activity of MnSOD and promoting the production of ROS.…”

Section: Introductionmentioning

confidence: 99%

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Association between serum manganese levels and diabetes in Chinese adults with hypertension

Chen

Zhixin

et al. 2022

J of Clinical Hypertension

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Manganese (Mn) is an essential trace metal element that is associated with diabetes; however, the results of previous studies are inconsistent. Furthermore, few studies have been conducted in a hypertensive population. The purpose of this study is to explore the relationship between manganese and diabetes in a population with hypertension. A cross-sectional study was conducted, including 2575 hypertensiveThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between serum manganese levels and diabetes in Chinese adults with hypertension

Chen

Zhixin

et al. 2022

J of Clinical Hypertension

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“…However, the above studies have not evaluated the effects of manganese exposure on CVD. In the previous published research, blood manganese levels were negatively correlated with CVD risk based on the published NHANES data [ 5 ]. Nevertheless, the mechanism of the association between heavy metals and the risk of CVD is very complicated.…”

Section: Discussionmentioning

confidence: 99%

Serum 25-hydroxyvitamin D mediates the association between heavy metal exposure and cardiovascular disease

Lu,

Zhang

et al. 2024

BMC Public Health

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Background Mediation analysis aims to determine how intermediate variables affect exposure to disease. In this study, 25-hydroxyvitamin D (25(OH)D) was evaluated to assess its role in mediating heavy metal exposure and cardiovascular disease (CVD). Methods A total of 9,377 participants from the National Health and Nutrition Examination Survey (NHANES) for the years 2011-2018 were included. Firstly, restricted cubic spline (RCS), and multivariable logistic regression model were performed to estimate the association between heavy metal exposure (Cadmium, Lead, Mercury, Manganese, and Selenium), as well as serum 25(OH)D and CVD. Secondly, using generalized linear regression model and generalized additive models with smooth functions, we investigated the correlation between heavy metal exposure and serum 25(OH)D. Finally, the mediation effect of serum 25(OH)D in the associations between heavy metal exposure and CVD was explored. Results The RCS plots revealed that Cadmium, and Lead were positively and linearly associated with CVD, while Mercury, and Manganese were inversely and linearly associated with CVD. Additionally, a roughly L- and U-shaped relationship existed between Selenium, as well as 25(OH)D and CVD. When potential confounding factors were adjusted for, serum 25(OH)D had negative associations with Cadmium, Lead, and Manganese, while serum 25(OH)D had positive relationship with Selenium. There was a mediation effect between Manganese exposure and CVD, which was mediated by 25(OH)D. Conclusion According to the mediation analysis, the negative association between Manganese exposure and incident CVD was increased by 25(OH)D. The increasing dietary intake of Vitamin D could increase the protective effect of manganese intake on CVD.

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“…The National Health and Nutrition Examination Survey (NHANES) is an accessible database from the United States that contains questionnaire data on national health and nutritional status ( Yang et al, 2014 ) as well as the results of laboratory and imaging tests ( Xiao et al, 2021 ). Continuous information on the non-institutionalized US population was included in the NHANES, with every 2 years representing 1 cycle.…”

Section: Methodsmentioning

confidence: 99%

“…We explored the association between serum manganese and serum klotho levels after adjusting for covariates selected in accordance with the literature ( Xiao et al, 2021 ; Kim et al, 2022 ; Kresovich and Bulka, 2022 ). Sociodemographic characteristics were obtained using computer-assisted questionnaires, which included age, gender, race, educational attainment, marital status, and PIR.…”

Section: Methodsmentioning

confidence: 99%

Association between serum manganese and serum klotho in a 40–80-year-old American population from NHANES 2011–2016

et al. 2023

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Objectives: Manganese is one of the essential trace elements that are required by the human body. Klotho protein is a classic anti-aging marker. The association between the levels of serum manganese and serum klotho in individuals between the ages of 40–80 in the United States remains unclear.Methods: Data for this cross-sectional study was obtained from the National Health and Nutrition Examination Survey (NHANES 2011–2016) in the United States. We performed multiple linear regression analyses to investigate the association between the levels of serum manganese and serum klotho. Furthermore, we performed a fitted smoothing curve according to a restricted cubic spline (RCS). Stratification and subgroup analyses were performed for further verification of the results.Results: Weighted multivariate linear regression analysis showed that serum manganese levels were independently and positively associated with serum klotho levels (β = 6.30, 95% confidence interval: 3.30–9.40). Kruskal–Wallis test showed that participants with higher manganese quartiles had higher serum klotho levels (Q1: 808.54 ± 256.39 pg/mL; Q2: 854.56 ± 266.13 pg/mL; Q3: 865.13 ± 300.60 pg/mL; and Q4: 871.72 ± 338.85 pg/mL, p < 0.001). The RCS curve indicated that the association between the levels of serum manganese and serum klotho was non-linear. Furthermore, a significantly positive association was found between serum manganese and serum klotho levels in the majority of subgroups.Conclusion: A non-linear and positive association was found between the levels of serum manganese and serum klotho in individuals aged 40–80 in the United States according to the NHANES (2011–2016).

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The association between manganese exposure with cardiovascular disease in older adults: NHANES 2011–2018

Cited by 10 publications

References 22 publications

Association between serum manganese levels and diabetes in Chinese adults with hypertension

Association between serum manganese levels and diabetes in Chinese adults with hypertension

Serum 25-hydroxyvitamin D mediates the association between heavy metal exposure and cardiovascular disease

Association between serum manganese and serum klotho in a 40–80-year-old American population from NHANES 2011–2016

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