The Association between Low Birth Weight and Dental Caries of Primary Teeth among Jordanian Children

Athamneh, Tarek; Al-Shraideh, Ziad; Malkawi, Tamador Fahmi

doi:10.5742/mefm.2014.92457

Cited by 2 publications

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“…Bernabé et al also found that maternal weight and maternal smoking were associated with changes in dmft and that children with low birth weight and smoking mothers showed a higher rate of caries than children with normal birth weight and non-smoking mothers [46]. These results were in line with ours but Athamneh et al assessed 30 to 48 months children and concluded that there isn't a signi cant relationship between birth weight and dental caries [47].Some studies have shown that the children of parents with higher education have better oral health. In the present study a statistically signi cant positive correlation between salivary cystatin S and parent, education was found.…”

Section: Discussionsupporting

confidence: 79%

Salivary Cystatin S in Children With Early Childhood Caries in Comparison With Caries-free Children; Statistical Analysis and Machine Learning

Koopaie

Salamati

Montazeri

et al. 2021

Preprint

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Background: Early childhood caries is the most common infectious disease in childhood, with a high prevalence in developing countries. Recognition of the factors affecting early childhood caries and its pathophysiology, allows better control of disease. Cystatin S as one of the salivary proteins, has an important role in pellicle formation, tooth re-mineralization and protection. The aim of the present study is to assess salivary cystatin S levels and demographic data in early childhood caries children in comparison with caries-free ones using statistical analysis and machine learning methods. Methods: A cross-sectional case-control study was undertaken on 20 cases of early childhood caries and 20 caries-free children as a control group. Unstimulated whole saliva samples by suction method was collected. Cystatin S concentrations were determined using human cystatin S ELISA kit. A checklist was collected for each participant about the demographic characteristics, oral health status and dietary habits by interviewing parents. The regression and receiver operating characteristic (ROC) curve analysis was done to evaluate the potential role of cystatin S salivary level and demographic using machine learning and statistical analysis.Results: The mean value of salivary cystatin S concentration in early childhood caries group was 191.55±81.90 (ng/ml) and in caries-free group was 370.06±128.87 (ng/ml). T-test analysis showed that there is a statistically significant difference between early childhood caries and caries-free group in salivary cystatin S level (p: 0.032). Investigation of area under the curve and accuracy of ROC curve revealed that logistic regression model based on the salivary cystatin S levels and birth weight had most and acceptable potential for discriminating of early childhood caries from caries-free controls. After that the machine learning models and finally salivary cystatin S levels had more capability for differentiation of early childhood caries from caries-free controls.Conclusion: Salivary cystatin S in caries-free children was higher than the children with early childhood caries. Therefore, cystatin S protein can be used as a biomarker for early prediction of early childhood caries, furthermore cystatin S is a protective factor against dental caries.

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Section: Discussionsupporting

confidence: 79%

Salivary Cystatin S in Children With Early Childhood Caries in Comparison With Caries-free Children; Statistical Analysis and Machine Learning

Koopaie

Salamati

Montazeri

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

Salivary cystatin S levels in children with early childhood caries in comparison with caries-free children; statistical analysis and machine learning

et al. 2021

View full text Add to dashboard Cite

Background Early childhood caries is the most common infectious disease in childhood, with a high prevalence in developing countries. The assessment of the variables that influence early childhood caries as well as its pathophysiology leads to improved control of this disease. Cystatin S, as one of the salivary proteins, has an essential role in pellicle formation, tooth re-mineralization, and protection. The present study aims to assess salivary cystatin S levels and demographic data in early childhood caries in comparison with caries-free ones using statistical analysis and machine learning methods. Methods A cross-sectional, case–control study was undertaken on 20 cases of early childhood caries and 20 caries-free children as a control. Unstimulated whole saliva samples were collected by suction. Cystatin S concentrations in samples were determined using human cystatin S ELISA kit. The checklist was collected from participants about demographic characteristics, oral health status, and dietary habits by interviewing parents. Regression and receiver operating characteristic (ROC) curve analysis were done to evaluate the potential role of cystatin S salivary level and demographic using statistical analysis and machine learning. Results The mean value of salivary cystatin S concentration in the early childhood caries group was 191.55 ± 81.90 (ng/ml) and in the caries-free group was 370.06 ± 128.87 (ng/ml). T-test analysis showed a statistically significant difference between early childhood caries and caries-free groups in salivary cystatin S levels (p = 0.032). Investigation of the area under the curve (AUC) and accuracy of the ROC curve revealed that the logistic regression model based on salivary cystatin S levels and birth weight had the most and acceptable potential for discriminating of early childhood caries from caries-free controls. Furthermore, using salivary cystatin S levels enhanced the capability of machine learning methods to differentiate early childhood caries from caries-free controls. Conclusion Salivary cystatin S levels in caries-free children were higher than the children with early childhood caries. Results of the present study suggest that considering clinical examination, demographic and socioeconomic factors, along with the salivary cystatin S levels, could be usefull for early diagnosis ofearly childhood caries in high-risk children; furthermore, cystatin S is a protective factor against dental caries.

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The Association between Low Birth Weight and Dental Caries of Primary Teeth among Jordanian Children

Cited by 2 publications

References 0 publications

Salivary Cystatin S in Children With Early Childhood Caries in Comparison With Caries-free Children; Statistical Analysis and Machine Learning

Salivary Cystatin S in Children With Early Childhood Caries in Comparison With Caries-free Children; Statistical Analysis and Machine Learning

Salivary cystatin S levels in children with early childhood caries in comparison with caries-free children; statistical analysis and machine learning

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