The association between fatigue and inflammatory marker levels in cancer patients: A quantitative review

Schubert, Christian; Hong, Suzi; Mills, Paul J.; Dimsdale, Joel E.

doi:10.1016/j.bbi.2006.11.004

Cited by 311 publications

(269 citation statements)

References 63 publications

Supporting

Mentioning

244

Contrasting

Unclassified

Order By: Relevance

“…Our recent work extends these findings to the acute treatment setting and suggests that activation of proinflammatory cytokines may also play a role in fatigue onset during radiation therapy among both breast and prostate cancer patients . These results are consistent with a recent review of the literature on fatigue and inflammatory markers in cancer patients, which found a positive association between cancer-related fatigue and circulating levels of IL-1ra, IL-6, and neopterin (Schubert et al, 2007).…”

Section: Conclusion and Recommendations For Future Researchsupporting

confidence: 82%

Cancer-related fatigue: Links with inflammation in cancer patients and survivors

Bower

2007

Brain, Behavior, and Immunity

219

153

View full text Add to dashboard Cite

Fatigue is one of the most common and distressing side effects of cancer and its treatment and may persist long after successful treatment completion. Emerging evidence suggests that inflammatory processes may be involved in cancer-related fatigue both during and after treatment. In this review, we consider the evidence for an association between inflammation and fatigue in cancer patients and survivors. Further, we identify potential mechanisms for persistent inflammation, focusing on the HPA axis. Risk factors and treatments for cancer-related fatigue are also discussed.

show abstract

Section: Conclusion and Recommendations For Future Researchsupporting

confidence: 82%

Cancer-related fatigue: Links with inflammation in cancer patients and survivors

Bower

2007

Brain, Behavior, and Immunity

219

153

View full text Add to dashboard Cite

show abstract

“…It has been found thatpatientswithbreastcancerwhohavefatiguehaveincreased levels of pro-inflammatory cytokines, including IL-6 and IL-1RA [17]. It has also been shown that the pro-inflammatory cytokines interferon-␣ (IFN-␣) and IL-2), which are used in the treatment of cancer, can cause fatigue and depression [18,19].…”

Section: Discussionmentioning

confidence: 99%

The Systemic Inflammatory Response and Its Relationship to Pain and Other Symptoms in Advanced Cancer

et al. 2013

View full text Add to dashboard Cite

Introduction. Inflammation has been identified as a hallmark of cancer and may be necessary for tumorgenesis and maintenance of the cancer state. Inflammation‐related symptoms are common in those with cancer; however, little is known about the relationship between symptoms and systemic inflammation in cancer. The aim of the present study was to examine the relationship between symptoms and systemic inflammation in a large cohort of patients with advanced cancer. Methods. Data from an international cohort of patients with advanced cancer were analyzed. Symptoms and patient‐related outcomes were recorded using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire—Core Questionnaire. Systemic inflammation was assessed using C‐reactive protein levels. The relationship between these symptoms and systemic inflammation was examined using Spearman rank correlation (ρ) and the Mann‐Whitney U test. Results. Data were available for 1,466 patients across eight European countries; 1,215 patients (83%) had metastatic disease at study entry. The median survival was 3.8 months (interquartile range [IQR] 1.3–12.2 months). The following were associated with increased levels of inflammation: performance status (ρ = .179), survival (ρ = .347), pain (ρ = .154), anorexia (ρ = .206), cognitive dysfunction (ρ = .137), dyspnea (p= .150), fatigue (ρ = .197), physical dysfunction (ρ = .207), role dysfunction (ρ = .176), social dysfunction (ρ = .132), and poor quality of life (ρ = .178). All were statistically significant at p < .001. Conclusion. The results show that the majority of cancer symptoms are associated with inflammation. The strength of the potential relationship between systemic inflammation and common cancer symptoms should be examined further within the context of an anti‐inflammatory intervention trial.

show abstract

“…Janszky et al (130) found that high-sensitivity C-reactive protein (hsCRP) and Interleukin-6 (IL-6) are associated with fatigue in older women after recent myocardial infarction. Schubert et al (131) found that IL-6, Interleukin-1 receptor antagonist (IL1ra) and neopterin are related to fatigue in cancer patients, and two studies showed that hsCRP is related to fatigue in population-based samples of 33-45-year-olds (132) and in persons over age 65 (62). However, Vestergaard et al (62) also found that IL-6 and TNF-alpha are not related to fatigue in this older population.…”

confidence: 99%

Fatigue in older adults: an early indicator of the aging process?

2010

View full text Add to dashboard Cite

show abstract

The association between fatigue and inflammatory marker levels in cancer patients: A quantitative review

Cited by 311 publications

References 63 publications

Cancer-related fatigue: Links with inflammation in cancer patients and survivors

Cancer-related fatigue: Links with inflammation in cancer patients and survivors

The Systemic Inflammatory Response and Its Relationship to Pain and Other Symptoms in Advanced Cancer

Fatigue in older adults: an early indicator of the aging process?

Contact Info

Product

Resources

About