The association between cytomegalovirus infection, obesity, and metabolic syndrome in U.S. adult females

Fleck-Derderian, Shannon; McClellan, William; Wojcicki, Janet M.

doi:10.1002/oby.21764

Cited by 38 publications

(35 citation statements)

References 40 publications

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“…Clinical observations have displayed that patients with acute Epstein-Barr virus(EBV) infection had lower levels of Apo-AI, HDL-C, TC, Apo B, LDL-C and LP-A compared with their controls [25]. Another study showed that cytomegalovirus(CMV) infection was associated with lower HDL-C in normal-weight females [26].…”

Section: Discussionmentioning

confidence: 99%

Changes in lipid metabolism in patients with severe COVID-19

Li¹,

Zhang²,

Dai³

et al. 2020

Preprint

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Background: Dyslipidemia plays an important role in the pathogenesis and evolution of critical illness, but limited information exists regarding the lipid metabolism of severe coronavirus disease 2019 (COVID-19) patients. The aim of this study was to investigate role of dyslipidemia in patients with severe COVID-19Methods: We retrospectively reviewed 216 severe COVID-19 patients with clarified outcomes (discharged or deceased), admitted to the West Court of Union Hospital in Wuhan, China, between February 1 and March 31, 2020. The dynamic changes of lipid profiles and their relationships with disease severity and clinical outcomes were analyzed.Results: A total of 216 severe COVID-19 patients, including 24 non-survivors and 192 survivors, were included in the final analyses. The levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein AI (Apo-AI) on admission were significantly lower in non-survivors compared to survivors. During hospitalization, low-density lipoprotein cholesterol (LDL-C), total cholesterol(TC), HDL-C and Apo-AI were shown an increasing trend in survivors, but maintained lower levels or shown downward trend in non-survivors. The serum levels of HDL-C and Apo-AI were inversely correlated with C-reactive protein (CRP), length of hospital stay of survivors and disease severity. The receiver operating characteristic (ROC) curve analysis identified a CRP/ HDL-C ratio cut-off value of 62.54 as the predictor for in-hospital mortality (AUC=0.823, Sensitivity=83.3%, Specificity=70.8%). Logistic regression analysis demonstrated that hypertension, neutrophils-to-lymphocytes ratio(NLR), platelet count and high CRP/ HDL-C ratio (>62.54) were independent factors to predict in-hospital mortality.Conclusions: The results demonstrated that dyslipidemia was associated with the inflammatory response, disease severity and poor prognosis of COVID-19. High CRP/ HDL-C ratio may serve as an independently potential predictor for hospital mortality among patients with severe COVID-19.

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Section: Discussionmentioning

confidence: 99%

Changes in lipid metabolism in patients with severe COVID-19

Li¹,

Zhang²,

Dai³

et al. 2020

Preprint

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“…We have previously found that CMV is associated with a flatter cortisol rhythm over the day, and with accelerated telomere shortening over three years (Dowd et al, 2017, Steptoe et al, 2009). CMV also affects metabolic processes, though associations with adiposity are poorly understood (Fleck-Derderian et al, 2017). Associations between CMV seropositivity, SES and central adiposity were therefore assessed in this study.…”

Section: Introductionmentioning

confidence: 99%

Socioeconomic status and central adiposity as determinants of stress-related biological responses relevant to cardiovascular disease risk

Steptoe

Hiltl

Dowd

et al. 2019

Brain, Behavior, and Immunity

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“…Interestingly, there is evidence of sex differences in both ganciclovir pharmacokinetics and the anti-CMV immune response. [11][12][13][14][15][16][17][18] Thus, female patients have been shown to have a faster ganciclovir clearance, and distinct anti-CMV immunological profiles e.g. higher number of secreting anti-CMV T cells.…”

Section: Introductionmentioning

confidence: 99%

Sex-associated differences in cytomegalovirus prevention: Prophylactic strategy is associated with a strong kidney function impairment in female renal transplant patients

Blázquez-Navarro

Dang-Heine

Bauer

et al. 2019

Preprint

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Post-transplantation cytomegalovirus (CMV) syndrome can be prevented using the antiviral drug (val)ganciclovir. (Val)ganciclovir is typically administered following a prophylactic or a pre-emptive strategy. The prophylactic strategy entails early universal administration, the pre-emptive strategy, early treatment in case of infection. However, it is not clear which strategy is superior with respect to transplantation outcome; sex-specific effects of these prevention strategies are not known. We have retrospectively analysed 540 patients from the multi-centre Harmony study along eight pre-defined visits: 308 were treated according to a prophylactic, 232 according to a pre-emptive strategy. As expected, we observed an association of prophylactic strategy with lower incidence of CMV syndrome, delayed onset and lower viral loads compared to the pre-emptive strategy. However, in female patients, the prophylactic strategy was associated with a strong impairment of glomerular filtration rate one year post-transplant (difference: -12.0±4.2 mL·min -1 ·1.73m -2 , P=0.005). Additionally, we observed a tendency of higher incidence of acute rejection and severe BK virus reactivation in the prophylactic strategy group. While the prophylactic strategy was more effective for preventing CMV syndrome, our results suggest for the first time that the prophylactic strategy might lead to inferior transplantation outcomes in female patients, providing evidence for a strong association with sex.

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The association between cytomegalovirus infection, obesity, and metabolic syndrome in U.S. adult females

Cited by 38 publications

References 40 publications

Changes in lipid metabolism in patients with severe COVID-19

Changes in lipid metabolism in patients with severe COVID-19

Socioeconomic status and central adiposity as determinants of stress-related biological responses relevant to cardiovascular disease risk

Sex-associated differences in cytomegalovirus prevention: Prophylactic strategy is associated with a strong kidney function impairment in female renal transplant patients

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