The association between birthweight 4000 g or greater and perinatal outcomes in patients with and without gestational diabetes mellitus

Esakoff, Tania F.; Cheng, Yvonne W.; Sparks, Teresa N.; Caughey, Aaron B.

doi:10.1016/j.ajog.2009.02.035

Cited by 202 publications

(147 citation statements)

References 16 publications

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“…In clinical practice, birthweight ≥3,500 g predicts an increased risk of a difficult vaginal delivery, and macrosomia is the strongest risk factor for maternal/fetal birth injuries1, 29, 30, 31 and increases the risk of obesity32, and cardiovascular diseases in the offspring. No single measure was clearly superior in predicting macrosomia.…”

Section: Discussionmentioning

confidence: 99%

Association between glycemic control and birthweight with glycated albumin in Chinese women with gestational diabetes mellitus

Wang²,

Tao

et al. 2015

J of Diabetes Invest

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Aims/IntroductionTo assess glycated albumin (GA) as a potential glycemic index in managing gestational diabetes mellitus (GDM).Materials and MethodsEligible pregnant women were divided into the GDM group with abnormal result on a 75‐g oral glucose tolerance test (OGTT) and the control (normal) group. GA measurements, Pearson's correlation analysis, multiple logistic regression and receiver operating characteristic curve analysis were obtained at the follow‐up examination of participants in the two groups.ResultsA total of 2,118 women were assigned to the GDM group (n = 639) and control group (n = 1,479). The mean level of serum GA in GDM group was significantly greater than that in the control group at both 24–28 and 36–38 weeks of gestation (P < 0.05). The area under the receiver operating characteristic curve for GA defining good glycemic control in GDM was 0.874 (95% confidence interval 0.811–0.938). The cut‐off point for the GA levels derived from the receiver operating characteristic curve was 11.60%, which had sensitivity and specificity for detecting a poor glycemic status of 75.93% and 86.36%, respectively. The risk of birthweight ≥3,500 g and macrosomia increased significantly with GA levels ≥13.00% at 24–28 weeks and ≥12.00% at 36–38 weeks of gestation.ConclusionsGA might be an appropriate and conveniently measured index that can detect poor glycemic control and predict birthweights in GDM women.

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Section: Discussionmentioning

confidence: 99%

Association between glycemic control and birthweight with glycated albumin in Chinese women with gestational diabetes mellitus

Wang²,

Tao

et al. 2015

J of Diabetes Invest

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“…In addition to this, statistic show a double risk of GDM in smokers (5). Babies born from mothers affected by GDM are typically at increased risk of macrosomia (6,7,8). And of additional problems such as the development of childhood obesity and of type 2 diabetes later in life.…”

Section: Introductionmentioning

confidence: 99%

Gestational Diabetes Mellitus (GDM) in the Republic of Kosovo: a Retrospective Pilot Study.

Daci¹,

Elshani²,

Beretta³

2013

Med Arh

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3B ackground: GDM is a condition in which women without previously diagnosed diabetes exhibit high blood glucose levels during pregnancy. Pregnancy causes some insulin resistance in all women, but only a few develop GDM. Objective: To test the hypothesis that women with GDM have impaired regulation of blood iron storage and transport, decreased renal function due to decreased glomerular filtration rate and occurrence of urinary tract infection (UTI). Study design and Methods: Incidence of blood iron storage was investigated in n=30 pregnant kosovar women with GDM after mild of pregnancy and in n=30 pregnant women without GDM (years 2010-2012). Results and Discussion: Baby weights, both systolic and diastolic BP, creatinine, albumin, lymphocytes, monocytes, WBC and granulocytes in both groups were within their normal ranges in both groups. Compared to control group, glucose was higher in women with GDM (mean ± SD: 7.43±2.23 mg/dL vs. 4.33±0.63 mg/dL; P<0.001). Women with GDM had also higher RBC (mean ± SD: 4.4±0.8 % vs. 3.8 ± 0.3 %; P<0.005) and HGB (mean ± SD: 13.0±3.2 g/dL vs. 11.2±1.4 mg/dL; P<0.05), and decreased renal functionality (MDRD-GFR: 92.8 ± 25.8 g/dL vs. 108.2 ± 38.2 g/dL; P<.05).Conclusion: There is a potential association between iron status and GDM. The role of iron from diet and/or from supplementation in GDM pathogenesis needs still to be examined. In addition we have observed a decrease of glomerular filtration rate in women with GDM. Due to the lack of studies on the relationships between GDM and UTI, and to the retrospective design of the present investigation, it is difficult to establish whether UTI may be a GDM causal factor or a consequence of GDM symptoms, signs and/or of its correlated pathologies.

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“…Large-for-gestational-age (LGA) status was defined as a birth weight above the 90 th percentile for age, and SGA was defined as a birth weight below the 10 th percentile for age [12]. Macrosomia was defined as an estimated fetal weight of 4,000 g or more, regardless of gestational age [13]. All patients underwent ultrasound examinations before proceeding to the delivery ward.…”

Section: Study Proceduresmentioning

confidence: 99%

Does reactive hypoglycemia during the 100 g oral glucose tolerance test adversely affect perinatal outcomes?

Delibaş¹,

Tanrıverdi²,

Çakmak³

2018

Ginekol Pol

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Objectives: To determine whether pregnant women who have reactive hypoglycemia during the 100 g oral glucose tolerance test (OGTT) are at an increased risk of poor pregnancy outcomes. Material and methods:We retrospectively analyzed perinatal data from 413 women who underwent a 3 h OGTT at 24-28 weeks of gestation and gave birth in our clinics between January 2012 and December 2014.Results: According to OGTT results, the majority of the subjects were normoglycemic (n = 316, 76.5%), while 49 (11.9%) were diagnosed with gestational diabetes, and 33 (8.0%) had single high glucose values. Reactive hypoglycemia was detected in only 15 patients (3.6%). The mean age of the women in the reactive hypoglycemia group was significantly lower than that of the women in the gestational diabetes and single high glucose value groups (26.4 ± 4.4 years, 31.4 ± 5.4 years, and 31.8 ± 4.3 years, respectively; p < 0.05). The newborns of the women in the reactive hypoglycemia group had higher rates of APGAR scores < 7, increased admission to the neonatal intensive care unit (NICU), and lower birth weights compared with the other groups (p < 0.001, p < 0.001, and p = 0.009, respectively). Conclusion:Reactive hypoglycemia during the 3 h 100 g OGTT is significantly associated with low APGAR scores, low birth weights, and prenatal admission to the NICU. Therefore, pregnant women who develop hypoglycemia during the 100 g OGTT performed at 24-28 weeks of gestation should receive attentive follow-up care to decrease the possibility of adverse perinatal outcomes.

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The association between birthweight 4000 g or greater and perinatal outcomes in patients with and without gestational diabetes mellitus

Cited by 202 publications

References 16 publications

Association between glycemic control and birthweight with glycated albumin in Chinese women with gestational diabetes mellitus

Association between glycemic control and birthweight with glycated albumin in Chinese women with gestational diabetes mellitus

Gestational Diabetes Mellitus (GDM) in the Republic of Kosovo: a Retrospective Pilot Study.

Does reactive hypoglycemia during the 100 g oral glucose tolerance test adversely affect perinatal outcomes?

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