The association between angiotensin II type 1 receptor A1166C gene polymorphism and the risk of essential hypertension: a meta-analysis

Fajar, Jonny Karunia; Susanti, M; Pikir, Budi Susetyo; Saka, Putu Nina Berlinda; Sidarta, Erdo Puncak; Tamara, Fredo; Akbar, Rizal Rahmanda; Hutama, Saga Aditya; Gunawan, Atma; Heriansyah, Teuku

doi:10.1186/s43042-019-0016-3

Cited by 11 publications

(5 citation statements)

References 75 publications

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“…Similarly, among north Indian patients with ID + DD ACE and 1166AC + CC AGTR1 , the combined genotype had a much higher risk of acute myocardial infarction than with II ACE and the 1166AA AGTR1 combined genotype [ 35 ]. Furthermore, the meta-analysis showed that the C allele and AC genotype of AGTR1 was associated with an increased risk of essential hypertension, while a decreased risk of essential hypertension was observed in the A allele and AA genotype [ 36 ]. However, it is worth noting that, in the Swedish population, it was reported that the interaction between the AC/CC AGTR1 and DD ACE genotypes is a predictor of survival for patients with HF [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

The Genetic Variants in the Renin-Angiotensin System and the Risk of Heart Failure in Polish Patients

Gorący

Kaczmarczyk

et al. 2022

Genes

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(1) Background: Heart failure (HF) is a complex disease and one of the major causes of morbidity and mortality in the world. The renin-angiotensin system (RAS) may contribute to the pathogenesis of HF. (2) Aim: To investigate the association of RAS key genetic variants, rs5051 (A-6G) in the gene encoding angiotensinogen (AGT), rs4646994 (I/D) in the gene for angiotensin I converting enzyme (ACE), and rs5186 (A1166C) in the gene encoding type 1 receptor for angiotensin II (AGTR1), with the HF risk in the cohort of Polish patients. (3) Methods: The study group consisted of 415 patients that were diagnosed with HF, while the control group comprised of 152 healthy individuals. Genomic DNA were extracted from blood and genotyping was carried out using either PCR or PCR-RFLP for ACE or AGT and AGTR1 variants, respectively. (4) Results: No association has been found between the I/D ACE and heart failure. The HF risk was significantly higher for AG AGT heterozygotes (overdominance: AG versus AA + GG) and for carriers of the G AGT allele in codominant and dominant modes of inheritance. However, the risk of HF was significantly lower in the carriers of at least one C AGTR1 allele (AC or CC genotypes) or in AC AGTR1 heterozygotes (overdominant mode). There was a significant relationship for AGT and HF patients in NYHA Class I-II for whom the risk was higher for the carriers of the G allele, and for the AG heterozygotes. There was also a significant interaction between heterozygote advantage of AGT and BMI increasing the risk for HF. (5) Conclusion: Our results suggest that the A(-6)G AGT polymorphism may be associated with HF in the Polish population and the HF risk seems to be modulated by the A1166C AGTR1 polymorphism.

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Section: Discussionmentioning

confidence: 99%

The Genetic Variants in the Renin-Angiotensin System and the Risk of Heart Failure in Polish Patients

Gorący

Kaczmarczyk

et al. 2022

Genes

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“…Nevertheless, our findings support an association between the AGTR1 A1166C gene polymorphism and HCM risk under the dominant model, as well as an association with DCM under the allelic and dominant models. Previous meta-analyses confirmed the association of the AGTR1 A1166C polymorphism with coronary heart disease [62,63] and essential hypertension [64]. However, only limited studies have investigated its relationship with cardiomyopathy.…”

Section: Plos Onementioning

confidence: 92%

Impact of the gene polymorphisms in the renin-angiotensin system on cardiomyopathy risk: A meta-analysis

Jia,

Meng,

Tang

et al. 2024

PLoS ONE

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Due to the inconsistent findings from various studies, the role of gene polymorphisms in the renin-angiotensin system in influencing the development of cardiomyopathy remains unclear. In this study, we conducted a systematic review and meta-analysis to summarize the findings regarding the impact of angiotensin converting enzyme (ACE) I/D, angiotensinogen (AGT) M235T, and angiotensin II Type 1 receptor (AGTR1) A1166C gene polymorphisms in patients with cardiomyopathy. We performed a comprehensive search of several electronic databases, including PubMed, Embase, the Cochrane Library, and Web of Science, covering articles published from the time of database creation to April 17, 2023. Studies on the assessment of genetic polymorphisms in genes related to the renin-angiotensin system in relation to cardiomyopathy were included. The primary outcome was cardiomyopathy. Risk of bias was assessed using the Newcastle-Ottawa Scale scale. The meta-analysis includes 19 studies with 4,052 cases and 5,592 controls. The ACE I/D polymorphisms were found to be associated with cardiomyopathy (allelic model D vs I: OR = 1.29, 95CI% = 1.08–1.52; dominant model DD+ID vs II: OR = 1.43, 95CI% = 1.01–2.02; recessive model DD vs ID+II: OR = 0.79, 95CI% = 0.64–0.98). AGT M235T polymorphism and cardiomyopathy were not significantly correlated (allelic model T vs M: OR = 1.26, 95CI% = 0.96–1.66; dominant model TT+MT vs MM: OR = 1.30, 95CI% = 0.98–1.73; recessive model TT vs MT+MM: OR = 0.63, 95CI% = 0.37–1.07). AGTR1 polymorphism and cardiomyopathy were not significantly associated under allelic model A vs C (OR = 0.69, 95CI% = 0.46–1.03) and recessive model AA vs CA+CC (OR = 0.89, 95CI% = 0.34–2.30), but under the dominant model AA+CA vs CC (OR = 0.51, 95CI% = 0.38–0.68). The current meta-analysis reveals that polymorphisms in ACE I/D may be a genetic risk factor for cardiomyopathy. There is an association between AGTR1 gene polymorphisms and risk of cardiomyopathy under the specific model.

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“…Moreover, to determine the association and effect estimates, data on allele and genotype frequency from selected papers were used to calculate the odds ratio (OR) and 95% confidence interval (95%CI). The protocols in our current study include paper selection, data extraction, quality assessment, and statistical analysis referred to our previous studies [14][15][16][17][18] , and we also used the checklist of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) to guide the protocols in our study 19 . A completed PRISMA checklist for the current study is available (DOI: https://doi.org/10.6084/m9.figshare.12016782) 98 .…”

Section: Methodsmentioning

confidence: 99%

Nitride oxide synthase 3 and klotho gene polymorphisms in the pathogenesis of chronic kidney disease and age-related cognitive impairment: a systematic review and meta-analysis

et al. 2020

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Background: While it has been known that the development of chronic kidney disease (CKD) and age-related cognitive impairment involves several mediators, the evidence in clinical practice only reveals nitride oxide synthase (NOS) and klotho. However, the evidence for this topic is conflicted. The aim of this study was to assess the role of NOS and klotho single nucleotide polymorphisms (SNPs) in the pathogenesis of CKD and age-related cognitive impairment. Methods: We performed a meta-analysis during October to December 2019. Paper collection was performed in major scientific websites, and we extracted information of interest from each paper. Data were analyzed using a Z-test with either random or fixed effect model. Results: Our initial assessment identified NOS3 G894T, NOS3 T786C, NOS3 4b/4a, klotho (KL) G395A, and KL C1818T as the gene candidate for our meta-analysis. Our pooled calculation revealed that NOS3 G894T was associated with the risk of both age-related cognitive impairment and CKD. Increased susceptibility to age-related cognitive impairment was observed in the GG genotype, and increased risk of CKD was found in patients with a single T allele and TT genotype for NOS3 nucleotide 894. For NOS3 4b/4a, increased risk of CKD was only found in 4a4a genotype. For NOS3 T786C, we failed to show the association with both CKD and age-related cognitive impairment. Subsequently, for KL G395A, A allele and GA genotype were found to correlate with increased susceptibility to CKD, while its correlation to age-related cognitive impairment was failed to clarify. For KL C1818T, our analysis failed to find the correlation with the risk of CKD. Conclusions: Our results reveal that the NOS3 G894T gene polymorphism has a crucial role in the pathogenesis of both CKD and age-related cognitive impairment.

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The association between angiotensin II type 1 receptor A1166C gene polymorphism and the risk of essential hypertension: a meta-analysis

Cited by 11 publications

References 75 publications

The Genetic Variants in the Renin-Angiotensin System and the Risk of Heart Failure in Polish Patients

The Genetic Variants in the Renin-Angiotensin System and the Risk of Heart Failure in Polish Patients

Impact of the gene polymorphisms in the renin-angiotensin system on cardiomyopathy risk: A meta-analysis

Nitride oxide synthase 3 and klotho gene polymorphisms in the pathogenesis of chronic kidney disease and age-related cognitive impairment: a systematic review and meta-analysis

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