The assessment of time-dependent myocardial changes in infants with perinatal hypoxia

Çetin, İ̇brahim İ̇lker; Kantar, Aslı; Ünal, Sevim; Çakar, Nilgün

doi:10.3109/14767058.2011.644365

Cited by 13 publications

(9 citation statements)

References 21 publications

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“…Indices of depressed cardiac function in this study parallel previously reported consequences of developmental hypoxia or intrauterine growth restriction in the sheep and human heart (6,22,29), suggesting that placental and maternal factors are not primarily responsible for cardiovascular adaptations to this stress. We found that developmental hypoxia decreased ⌬P/ ⌬t Max and increased , similar to findings from prior studies of the isolated, Langendorff-perfused fetal chicken heart at 90% of incubation (day 19; 38), and isolated muscle bundles from the 95% incubation (day 20) hypoxia-incubated chicken heart (48).…”

Section: Cardiac Functionsupporting

confidence: 86%

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Effects of chronic hypoxia on cardiac function measured by pressure-volume catheter in fetal chickens

Jonker

Giraud

Espinoza

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

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Hypoxia is a common component of many developmental insults and has been studied in early-stage chicken development. However, its impact on cardiac function and arterial-ventricular coupling in late-stage chickens is relatively unknown. To test the hypothesis that hypoxic incubation would reduce baseline cardiac function but protect the heart during acute hypoxia in late-stage chickens, white Leghorn eggs were incubated at 21% O2 or 15% O2. At 90% of incubation (19 days), hypoxic incubation caused growth restriction (-20%) and increased the LV-to-body ratio (+41%). Left ventricular (LV) pressure-volume loops were measured in anesthetized chickens in normoxia and acute hypoxia (10% O2). Hypoxic incubation lowered the maximal rate of pressure generation (ΔP/ΔtMax; -22%) and output (-57%), whereas increasing end-systolic elastance (ELV; +31%) and arterial elastance (EA; +122%) at similar heart rates to normoxic incubation. Both hypoxic incubation and acute hypoxia lengthened the half-time of relaxation (τ; +24%). Acute hypoxia reduced heart rate (-8%) and increased end-diastolic pressure (+35%). Hearts were collected for mRNA analysis. Hypoxic incubation was marked by decreased mRNA expression of sarco(endo)plasmic reticulum Ca(2+)-ATPase 2, Na(+)/Ca(2+) exchanger 1, phospholamban, and ryanodine receptor. In summary, hypoxic incubation reduces LV function in the late-stage chicken by slowing pressure generation and relaxation, which may be driven by altered intracellular excitation-contraction coupling. Cardiac efficiency is greatly reduced after hypoxic incubation. In both incubation groups acute hypoxia reduced diastolic function.

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Section: Cardiac Functionsupporting

confidence: 86%

“…Hypoxic stress during development has been investigated in a number of vertebrate models (6,18,32,46). Chronic fetal hypoxia has been linked to depressed fetal cardiac function in mammals (15,18,32,37) and is predictive of cardiovascular disease states later in life (16,26,27).…”

Section: Perspectives and Significancementioning

confidence: 99%

Effects of chronic hypoxia on cardiac function measured by pressure-volume catheter in fetal chickens

Jonker

Giraud

Espinoza

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Noncardiac disease, such as perinatal hypoxemia, persistent pulmonary hypertension, and sepsis, may be associated with cardiovascular biomarkers. [48][49][50] Gestational age plays a role in NT-proBNP levels, as demonstrated in premature neonates with and without PDA (the pattern of NT-proBNP levels is higher in neonates with PDA than in those in whom the PDA is closed), and NT-proBNP levels seem to follow a similar postnatal pattern in term neonates (in whom the levels decline over the first few days of life). 51,52 We did not recruit premature neonates or those who required neonatal inpatient care, populations in which the new test warrants further evaluation.…”

Section: Discussionmentioning

confidence: 91%

Evaluation of Circulating Cardiovascular Biomarker Levels for Early Detection of Congenital Heart Disease in Newborns in Sweden

et al. 2020

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“…Cetin et al ( 43 ) highlighted that the plasma BNP concentration in children with perinatal asphyxia on the first postpartum day was significantly higher than that in the control group, suggesting that BNP could be used as an indicator for the diagnosis of neonatal asphyxia. Jiang et al ( 42 ) drew similar conclusions, showing that the plasma BNP concentration at 12 h postpartum in the asphyxia group was significantly higher than that in the control group without asphyxia and myocardial injury.…”

Section: Manuscript Formattingmentioning

confidence: 99%

Application of B-Type Natriuretic Peptide in Neonatal Diseases

et al. 2021

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Numerous congenital or secondary diseases, including, heart disease, respiratory disease, sepsis and many others, can lead to neonatal death. B-type natriuretic peptide (BNP) is a peptide hormone secreted by ventricular cells following an increase in ventricular wall tension. BNP functions to promote vasodilation, diuresis, and sodium release to regulate blood pressure. BNP is a sensitive index reflecting ventricular function, which may aid the diagnosis and monitoring of various neonatal diseases. In neonates, there is currently no consensus on a reference BNP level, as the plasma BNP concentration of healthy newborns varies with age, peaks in the first week after birth, and then gradually decreased to a stable level. In disease states, the correlation between the plasma BNP concentration and the results of echocardiography is good, which is of great significance in the screening, monitoring, and prognosis evaluation of neonatal cardiovascular diseases, including congenital heart disease, patent ductus arteriosus, etcetera. It also facilitates the judgment of the efficacy of treatment and perioperative management. Moreover, the monitoring of plasma BNP concentration provides guidance for the diagnosis, evaluation, and treatment selection of certain neonatal respiratory diseases and neonatal sepsis. This review summarizes the normal BNP values and discusses the application value of BNP in relation to physiological and pathological aspects in neonates.

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The assessment of time-dependent myocardial changes in infants with perinatal hypoxia

Abstract: These findings demonstrated that the signs of myocardial damage due to perinatal hypoxia still present at first month.

Cited by 13 publications

References 21 publications

Effects of chronic hypoxia on cardiac function measured by pressure-volume catheter in fetal chickens

Effects of chronic hypoxia on cardiac function measured by pressure-volume catheter in fetal chickens

Evaluation of Circulating Cardiovascular Biomarker Levels for Early Detection of Congenital Heart Disease in Newborns in Sweden

Application of B-Type Natriuretic Peptide in Neonatal Diseases

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