The Assessment of Pulmonary Diffusing Capacity in Diabetes Mellitus with Regard to Microalbuminuria

Saler, Tayyibe; Çakmak, Gülfidan; Sağlam, Zuhal Aydan; Ataoğlu, Esra; Erdem, Tijen Yesim; Yenigün, Mustafa

doi:10.2169/internalmedicine.48.2417

Cited by 22 publications

(16 citation statements)

References 25 publications

(13 reference statements)

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“…In addition to impairments of skeletal muscle perfusion and metabolic function, both type 1 and type 2 diabetics exhibit decreases in alveolar gas-exchange capacity (261). Notable among type 1 diabetics is a thickening of the alveolar epithelial and the capillary endothelial basal laminae, that may be expected to result in impaired gas exchange, at least when elevations in metabolic rate are present.…”

Section: Diabetes and Diabetic Ketoacidosismentioning

confidence: 99%

Effects of Gas Exchange on Acid‐Base Balance

Lindinger

Heigenhauser

2012

Comprehensive Physiology

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This paper describes the interactions between ventilation and acid-base balance under a variety of conditions including rest, exercise, altitude, pregnancy, and various muscle, respiratory, cardiac, and renal pathologies. We introduce the physicochemical approach to assessing acid-base status and demonstrate how this approach can be used to quantify the origins of acid-base disorders using examples from the literature. The relationships between chemoreceptor and metaboreceptor control of ventilation and acid-base balance summarized here for adults, youth, and in various pathological conditions. There is a dynamic interplay between disturbances in acid-base balance, that is, exercise, that affect ventilation as well as imposed or pathological disturbances of ventilation that affect acid-base balance. Interactions between ventilation and acid-base balance are highlighted for moderate- to high-intensity exercise, altitude, induced acidosis and alkalosis, pregnancy, obesity, and some pathological conditions. In many situations, complete acid-base data are lacking, indicating a need for further research aimed at elucidating mechanistic bases for relationships between alterations in acid-base state and the ventilatory responses.

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Section: Diabetes and Diabetic Ketoacidosismentioning

confidence: 99%

Effects of Gas Exchange on Acid‐Base Balance

Lindinger

Heigenhauser

2012

Comprehensive Physiology

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“…Patients with type 2 diabetes (DM2) might be good candidates for hyperoxic exercise training as previous research indicated that DM2 patients frequently have a reduced diffusion capacity of the lungs (8–25 %), inversely related to blood glucose levels as well as duration and severity of DM2 [ 15 – 17 ]. Pathophysiological mechanisms explaining the impaired pulmonary function may be micro-angiopathy, chronic inflammation and autonomic neuropathy [ 16 , 18 ] resulting in a diminished alveolar micro-vascular reserve [ 15 , 17 , 19 – 21 ]. Impaired alveolar gas exchange in DM2 patients has been shown to correlate with a lower and workload capacity during aerobic type of exercise [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: a feasibility study

et al. 2016

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ObjectiveThe study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2).MethodsEleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20 % Wmax) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min−1). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained.ResultsArterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 ± 1.2 (0 L min−1); 18.5 ± 1.5 (5 L min−1); 21.7 ± 1.7 (10 L min−1); 24.0 ± 2.3 (15 L min−1). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air.ConclusionsAn SOF of 15 L min−1 appears to be more effective than 5 or 10 L min−1. Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.

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“…Saler et al compared DLCO between 80 healthy subjects 44 patients with type 1 DM and 68 patients with type 2 DM [170]. DLCO and the ratio of DLCO to VA were significantly decreased in patients with both types of DM, but not in the control group.…”

Section: Introductionmentioning

confidence: 99%

Chronic obstructive pulmonary disease and glucose metabolism: a bitter sweet symphony

Mirrakhimov

2012

Cardiovasc Diabetol

108

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Chronic obstructive pulmonary disease, metabolic syndrome and diabetes mellitus are common and underdiagnosed medical conditions. It was predicted that chronic obstructive pulmonary disease will be the third leading cause of death worldwide by 2020. The healthcare burden of this disease is even greater if we consider the significant impact of chronic obstructive pulmonary disease on the cardiovascular morbidity and mortality.Chronic obstructive pulmonary disease may be considered as a novel risk factor for new onset type 2 diabetes mellitus via multiple pathophysiological alterations such as: inflammation and oxidative stress, insulin resistance, weight gain and alterations in metabolism of adipokines.On the other hand, diabetes may act as an independent factor, negatively affecting pulmonary structure and function. Diabetes is associated with an increased risk of pulmonary infections, disease exacerbations and worsened COPD outcomes. On the top of that, coexistent OSA may increase the risk for type 2 DM in some individuals.The current scientific data necessitate a greater outlook on chronic obstructive pulmonary disease and chronic obstructive pulmonary disease may be viewed as a risk factor for the new onset type 2 diabetes mellitus. Conversely, both types of diabetes mellitus should be viewed as strong contributing factors for the development of obstructive lung disease. Such approach can potentially improve the outcomes and medical control for both conditions, and, thus, decrease the healthcare burden of these major medical problems.

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The Assessment of Pulmonary Diffusing Capacity in Diabetes Mellitus with Regard to Microalbuminuria

Cited by 22 publications

References 25 publications

Effects of Gas Exchange on Acid‐Base Balance

Effects of Gas Exchange on Acid‐Base Balance

Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: a feasibility study

Chronic obstructive pulmonary disease and glucose metabolism: a bitter sweet symphony

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