The aryl hydrocarbon receptor and estrogen receptor alpha differentially modulate nuclear factor erythroid-2-related factor 2 transactivation in MCF-7 breast cancer cells

Exposure to a continuous low dose of tetrachlorodibenzo-p-dioxin impairs the development of the tooth root in lactational rats and alters the function of apical papilla-derived stem cells

“…These results are inconsistent with findings that TCDD stimulates cell proliferation and induces cancer, suggesting that its effect on SCAPs involves a different mechanism. 23,24 Moreover, it is commonly believed that SCAPs form boneand dentine-like tissues in vivo and contribute to the generation of odontoblasts that mediate root dentinogenesis. [25][26][27][28] We show here that SCAPs differentiated into osteoblasts, generated calcium nodules in osteogenic medium in vitro, and formed dentine pulp-like tissue on the surface of a dentine scaffold in nude mice.…”

Control of lymphocyte homeostasis and effector function by the aryl hydrocarbon receptor

“…The putative AhR-binding sites are mapped across the whole genome [5]. Many studies have demonstrated that AhR can regulate a large number of gene expressions with diversified functions [6,7]. Notably, a well-characterised outcome of ligand-induced AhR activation is to initiate the negative feedback to limit the AhR signalling [8].…”

Empirical likelihood tests for nonparametric detection of differential expression from RNA-seq data

“…The 10 genes with highest likelihood ratio (after filtering of pseudogenes) are shown in Table 2, along with their likelihood ratio and corresponding (Yang et al, 2008;Salisbury et al, 2014) and HMOX1 (Lo and Matthews, 2013) are known to be regulated by AHR.…”