The Argus® II Retinal Prosthesis System

Luo, Yvonne Hsu-Lin; Cruz, Lyndon da

doi:10.1016/j.preteyeres.2015.09.003

Cited by 307 publications

(288 citation statements)

References 87 publications

(11 reference statements)

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“…Second, a cell-type-specific approach was applied to target ON bipolar cells, aiming to restore inner retinal signal processing features (Lagali et al, 2008). We now know from electronic prosthesis, transplantation experiments that patients are able to recognize letters and primitive visual schemes upon non-cell type specific electrical stimulation (Stingl et al, 2015; Luo and da Cruz, 2016). This indicates that a random retinal cell-targeting approach will likely restore image-forming vision.…”

Section: Optogenetic Vision Restoration Strategiesmentioning

confidence: 99%

Biophysical Properties of Optogenetic Tools and Their Application for Vision Restoration Approaches

Klapper

Swiersy

Bamberg

et al. 2016

Front. Syst. Neurosci.

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Optogenetics is the use of genetically encoded light-activated proteins to manipulate cells in a minimally invasive way using light. The most prominent example is channelrhodopsin-2 (ChR2), which allows the activation of electrically excitable cells via light-dependent depolarization. The combination of ChR2 with hyperpolarizing-light-driven ion pumps such as the Cl− pump halorhodopsin (NpHR) enables multimodal remote control of neuronal cells in culture, tissue, and living animals. Very soon, it became obvious that this method offers a chance of gene therapy for many diseases affecting vision. Here, we will give a brief introduction to retinal function and retinal diseases; optogenetic vision restoration strategies will be highlighted. We will discuss the functional and structural properties of rhodopsin-based optogenetic tools and analyze the potential for the application of vision restoration.

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Section: Optogenetic Vision Restoration Strategiesmentioning

confidence: 99%

Biophysical Properties of Optogenetic Tools and Their Application for Vision Restoration Approaches

Klapper

Swiersy

Bamberg

et al. 2016

Front. Syst. Neurosci.

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“…Retinal implants comprise the technology closest to the BrainPort (e.g. [8][9][10], reviewed in [11][12][13][14][15]). These devices are considered to be the frontrunners of artificial vision technology [16].…”

Section: Purpose and Scope Of This Reviewmentioning

confidence: 99%

Visual task performance in the blind with the BrainPort V100 Vision Aid

Stronks

Mitchell

Nau

et al. 2016

Expert Review of Medical Devices

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Introduction: The BrainPort ® V100 Vision Aid is a non-invasive assistive device for the blind based on sensory substitution. The device translates camera images into electrotactile stimuli delivered to the tongue. The BrainPort has recently received the CE mark and FDA approval and it is currently marketed to augment, rather than replace, the traditional assistive technologies such as the white cane or guide dog. Areas covered: In this work, we will review the functional studies performed to date with the BrainPort and we will highlight the critical factors that determine device performance, including the technology behind the BrainPort, the impediments to assessing device performance, and the impact of device training and rehabilitation. Expert commentary: The BrainPort enables blind people to perceive light, identify simple objects, recognize short words, localize simple objects, and detect motion and orientation of objects. To achieve this, proper rehabilitation and training regimes are crucial. ARTICLE HISTORY

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“…With the development of modern medicine and electronic technology, implantable medical devices have been widely used in modern medicine [1][2][3][4][5]. However, implantable medical devices face common challenges in the areas of energy supply and data transmission.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Energy and Data Wireless Transfer Attenuation in Biological Channel of Deep Implantable Medical Devices: Characteristic Analysis and Modeling

Li¹,

Yang²,

Yu³

et al. 2017

PIER M

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Abstract-The scheme of energy and data wireless transmission with the same carrier based on Mary Differentially-Encoded Amplitude and Phase Shift Keying (MDAPSK) technology is an effective method to implement energy supply and data communication for implantable medical devices. In this paper, based on a large number of finite-difference time-domain simulation analyses, combined with knowledge of the clinical demand for implantable medical devices, the 13.56-402 MHz band is selected as the biological channel frequency band, and attenuation characteristic analysis and mathematical modeling are carried out. Based on massive amounts of simulation data, the Levenberg-Marquardt and general global optimization methods are adopted to build a homogeneous and heterogeneous biological channel model in the aforementioned frequency band. In order to verify the reliability and versatility of the mathematical model, an adult male rabbit is employed for a living implantation experiment. Using a vector network analyzer, different frequency electromagnetic wave receiving efficiencies in different biological channels are measured. The measured data are highly consistent with the simulation data, which fully verifies the rationality of the proposed biological channel model. This work provides a theoretical basis and model reference for the clinical application of an implantable medical device wireless transmission system.

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The Argus® II Retinal Prosthesis System

Cited by 307 publications

References 87 publications

Biophysical Properties of Optogenetic Tools and Their Application for Vision Restoration Approaches

Biophysical Properties of Optogenetic Tools and Their Application for Vision Restoration Approaches

Visual task performance in the blind with the BrainPort V100 Vision Aid

Simultaneous Energy and Data Wireless Transfer Attenuation in Biological Channel of Deep Implantable Medical Devices: Characteristic Analysis and Modeling

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