The application of Raman spectroscopy for the detection and identification of microorganisms

Stöckel, Stephan; Kirchhoff, Johanna; Neugebauer, Ute; Rösch, Petra; Popp, Jürgen

doi:10.1002/jrs.4844

Cited by 205 publications

(162 citation statements)

References 165 publications

(304 reference statements)

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“…Previous studies have focused on monitoring phenotypic responses by bacteria in response to direct drug exposure to evaluate the impact of antibiotic treatment or to investigate the antibiotic mode of action 4–18 .…”

Section: Discussionmentioning

confidence: 99%

Raman spectral signature reflects transcriptomic features of antibiotic resistance in Escherichia coli

et al. 2018

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To be able to predict antibiotic resistance in bacteria from fast label-free microscopic observations would benefit a broad range of applications in the biological and biomedical fields. Here, we demonstrate the utility of label-free Raman spectroscopy in monitoring the type of resistance and the mode of action of acquired resistance in a bacterial population of Escherichia coli, in the absence of antibiotics. Our findings are reproducible. Moreover, we identified spectral regions that best predicted the modes of action and explored whether the Raman signatures could be linked to the genetic basis of acquired resistance. Spectral peak intensities significantly correlated (False Discovery Rate, p < 0.05) with the gene expression of some genes contributing to antibiotic resistance genes. These results suggest that the acquisition of antibiotic resistance leads to broad metabolic effects reflected through Raman spectral signatures and gene expression changes, hinting at a possible relation between these two layers of complementary information.

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Section: Discussionmentioning

confidence: 99%

Raman spectral signature reflects transcriptomic features of antibiotic resistance in Escherichia coli

et al. 2018

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“…Quantitative Raman spectroscopy is used to determine the actual drug concentrations in street cocaine and crack rocks and to identify possible adulterants in these samples for forensic toxicology and criminalistics. Furthermore, recent developments in Raman spectrometers (portable instruments and new excitation wavelengths) and advancements in data analysis offer exciting opportunities for new applications of Raman spectroscopy in the identification and quantification of drugs of abuse, including investigations conducted immediately at the scene of a crime . Vukosavljevic and co‐workers have offered novel insights into controlled drug release from coated pellets by confocal Raman microscopy (CRM).…”

Section: Pharmaceutical Food and Forensic Applicationsmentioning

confidence: 99%

Recent advances in linear and non‐linear Raman spectroscopy. Part XI

Nafie

2017

J Raman Spectroscopy

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This review, published annually, provides an overview of advances in the field of Raman spectroscopy as found in papers published in the preceding calendar year in the Journal of Raman Spectroscopy (JRS), as well as in trends over the past decade across journals that have published papers important to the field of Raman spectroscopy. This information is obtained from statistical data on article counts obtained from Clarivate Analytics' Web of Science Core Collection by year and by subfield of Raman spectroscopy. Additional information is gleaned from presentations at the IX International Conference on Advanced Vibrational Spectroscopy (ICAVS‐9) in Victoria, British Columbia, Canada, in June 2017 and those featuring Raman scattering at SCIX 2017 organized by the Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) in Reno, Nevada, USA, in October 2017. Coverage is also provided for topics from the European Conference on Non‐linear Optical Spectroscopy (ECONOS 2017) held in April 2017 in Jena, Germany, and the Ninth Congress on the Application of Raman in Art and Archaeology (RAA 2017) in October 2017 in Evora, Portugal. Finally, papers published in JRS in 2016 are highlighted and arranged by topics at the frontier of Raman spectroscopy. Based on this survey information, it is clear that Raman spectroscopy maintains a rapidly expanding influence across a wide range of novel disciplines and applications that provide sensitive photonic information of matter at the molecular level.

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“…202 Both solutions and tissue samples have been studied by this technique; we refer the reader to the latest review papers 203,204 for details of these studies in biological materials. Also, the recently developed MFM may be very useful in clinical analysis of biomaterials (see Figures 3 and 4).…”

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confidence: 99%

Physiological origin of biogenic magnetic nanoparticles in health and disease: from bacteria to humans

Gorobets¹,

Gorobets²,

Koralewski³

2017

IJN

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The discovery of biogenic magnetic nanoparticles (BMNPs) in the human brain gives a strong impulse to study and understand their origin. Although knowledge of the subject is increasing continuously, much remains to be done for further development to help our society fight a number of pathologies related to BMNPs. This review provides an insight into the puzzle of the physiological origin of BMNPs in organisms of all three domains of life: prokaryotes, archaea, and eukaryotes, including humans. Predictions based on comparative genomic studies are presented along with experimental data obtained by physical methods. State-of-the-art understanding of the genetic control of biomineralization of BMNPs and their properties are discussed in detail. We present data on the differences in BMNP levels in health and disease (cancer, neurodegenerative disorders, and atherosclerosis), and discuss the existing hypotheses on the biological functions of BMNPs, with special attention paid to the role of the ferritin core and apoferritin.

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The application of Raman spectroscopy for the detection and identification of microorganisms

Cited by 205 publications

References 165 publications

Raman spectral signature reflects transcriptomic features of antibiotic resistance in Escherichia coli

Raman spectral signature reflects transcriptomic features of antibiotic resistance in Escherichia coli

Recent advances in linear and non‐linear Raman spectroscopy. Part XI

Physiological origin of biogenic magnetic nanoparticles in health and disease: from bacteria to humans

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