2011
DOI: 10.1186/1476-511x-10-147
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Abstract: BackgroundAdvances in nanotechnology have identified promising candidates for many biological and biomedical applications. Since the properties of nanoparticles (NPs) differ from that of their bulk materials, they are being increasingly exploited for medical uses and other industrial applications. The histological and the histochemical alterations in the renal tissues due to gold nanoparticles (GNPs) have not well documented and have not yet been identified. The aim of the present study was to investigate the … Show more

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Cited by 46 publications
(47 citation statements)
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“…Apoptotic alteration might be followed by organelles swelling, specially mitochondria, endoplasmic reticulum, and rupture of lysosomes which might lead to amorphous eosinophilic cytoplasm as an initial sign in the sequence of hepatocytes necrosis before shrinking and dissolution of nuclei [13, 14]. The seen hepatocytes necrosis due to GNPs exposure might indicate oxidative stress on these cells by glutathione depletion [16, 17]. …”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Apoptotic alteration might be followed by organelles swelling, specially mitochondria, endoplasmic reticulum, and rupture of lysosomes which might lead to amorphous eosinophilic cytoplasm as an initial sign in the sequence of hepatocytes necrosis before shrinking and dissolution of nuclei [13, 14]. The seen hepatocytes necrosis due to GNPs exposure might indicate oxidative stress on these cells by glutathione depletion [16, 17]. …”
Section: Resultsmentioning
confidence: 99%
“…Samples were then impregnated with 2 changes of molten paraffin wax, and then embedded and blocked out. Paraffin sections (4-5  μ m) were stained with hematoxylin and eosin (the conventional histological and stain) according to [1517]. Stained sections of control and treated rats were examined for alterations in the hepatocytes for the presence of inflammatory, fatty change and Kupffer cells hyperplasia and necrosis [1315].…”
Section: Methodsmentioning
confidence: 99%
“…GNPs demonstrated oxidative stress and macromolecules interaction that could result in histocytotoxicity [9][10][11] . Some research works showed that GNPs with a size of of 5-20 nm were more toxic and had long time accumulation than the larger ones in the vital organs including the kidney [12][13][14] . The kidneys receive high blood flow and have high exposure to small GNPs with long circulating residue than the larger ones 9,15,16 .…”
Section: Introductionmentioning
confidence: 99%
“…Abdelhalim and Jarrar clearly observed damage to proximal tubular epithelial cells in rats exposed to GNPs. 34,35 Furthermore, numerous metallic nanoparticles are selective nephrotoxicants that preferentially accumulate in the kidneys, further to induce renal injury. [36][37][38][39] It has been known for some time that chronic kidney diseases (CKD) are often accompanied by hypoxic, which may play an important pathogenic role in the development of renal damage; 40 whereas, no study has been performed concerning GNP interactions with hypoxic kidney cells, especially proximal tubules.…”
Section: Introductionmentioning
confidence: 99%