The apoptotic efficacy of succinic acid on renal cancer cell lines

Kaşarci, Göksu; Ertuğrul, Barış; İplik, Elif Sinem; Çakmakoğlu, Bedia

doi:10.1007/s12032-021-01577-9

Cited by 11 publications

(5 citation statements)

References 30 publications

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“…The aromatic amino acid phenylalanine was seen to substitute tryptophan when depleted in melanoma cells for the biosynthesis of proteins [ 45 ]. While dual actions have been reported for succinic acid since it enhances cancer cell migration and promotes cancer metastasis [ 34 ], and displayed anti-cancer effects by inducing apoptosis in renal cancer [ 47 ]. In leukemia succinic acid had anti-proliferative activity and in vitro was seen to promote apoptosis in some leukemia cells [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Synergistic interactions of cytarabine-adavosertib in leukemic cell lines proliferation and metabolomic endpoints

Rodríguez-Vázquez,

Diaz-Quiñones,

Chorna

et al. 2023

Biomedicine & Pharmacotherapy

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Section: Discussionmentioning

confidence: 99%

Synergistic interactions of cytarabine-adavosertib in leukemic cell lines proliferation and metabolomic endpoints

Rodríguez-Vázquez,

Diaz-Quiñones,

Chorna

et al. 2023

Biomedicine & Pharmacotherapy

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“…[ 1 ] For example, succinic acid and its derivatives have experienced a rapid market expansion with an annual growth rate of 9.7% because of their increased demand for traditional applications (e.g., food additives and detergents), and growing interest as precursors for biodegradable polymers or anticarcinogenic agents. [ 1–2 ] The major manufacturing pathway for these organic acids is fermentation. [ 3 ] Recovering and purifying these organic acid products through downstream processing is one of the most challenging steps in biomanufacturing, due to the complexity of the fermentation broth, which contains residual carbohydrates (e.g., glucose), inorganic salts (e.g., NaCl), and a multitude of byproducts.…”

Section: Introductionmentioning

confidence: 99%

Precision Tuning of Highly Selective Polyelectrolyte Membranes for Redox‐Mediated Electrochemical Separation of Organic Acids

Kim

Lee

2023

Adv Funct Materials

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The design of molecularly selective membranes is of paramount importance in the electrochemical separation of organic acids from complex fermentation streams, due to the presence of multicomponent species. However, current membrane‐integrated electrochemical technologies have relied on ion‐exchange membranes that lack intrinsic ion‐selectivity, thus preventing their application for value‐added recovery of organic acids from competing ions. Here, this study demonstrates a layer‐by‐layer polyelectrolyte functionalization approach for controlling ion‐selectivity, to achieve the multicomponent separation of organic acids in a redox‐flow electrodialysis platform. This study carries out a detailed investigation of the surface morphology and physicochemical properties of functionalized membranes, underlying that the selectivity of organic acids can be precisely tuned through the control of the hydrophilicity, electrostatic repulsion, and steric hindrance. Tailoring of membrane physiochemical properties enables up to complete retention of succinate, while enhancing the total flux. This organic acid retention is extended to the control over mono‐ and multivalent organic acids. Integration of functionalized membrane with the redox‐flow system allows selective succinic acid recovery with 99.7% purity from a synthetic fermentation mixture, high energy efficiency, and membrane stability. Modulation of ion‐selectivity through membrane functionalization coupled with electrochemical architecture design enables a sustainable pathway for multicomponent separations in biomanufacturing.

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“…Succinic acid is the primary hypoglycaemic constituent in Desmodium canum , a plant traditionally used for its potential medicinal properties. [ 22 ] It has been demonstrated to have some biological activity as an anti‐diabetic, [ 23 ] antimicrobial, [ 24 ] antitumor, [ 25 ] antibacterial, [ 26 ] anticancer, [ 27 ] etc.…”

Section: Introductionmentioning

confidence: 99%

DFT, Molecular Docking, Energy‐Framework, In‐silico ADME Analysis of 2,6‐Diamino‐4‐chloropyrimidine–succinic Acid (2/1)

Chakkarapani,

Madhukar,

Venkatachalam

2023

Cryst. Res. Technol.

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Computational modelling and simulation have made it possible to considerably advance in the exploration of conformational and dynamical features of the desired compound. It not only assists in the interpretation of the experimental result, but also to provide insights about the internal motions of the molecule at the atomic level. In this work, Density Functional Theory calculations are performed to replicate the experimental electronic structure of 2C4H5ClN4.C4H6O4, and its nature is discussed in detail. The B3LYP/6‐311++G(d,p) basis set applied to evaluate the optimal structure characteristics resulted in revealing the corresponding chemical, physical, and biological properties of the molecule. The energy exchange between the contributor and receiver are examined by Natural Bond Orbital analysis. Based on frontier molecular orbitals analysis, the obtained minimum energy gap (0.199 eV) value ensures the stability of the title compound. The molecular electrostatic potential mapping predicts the electrophilic and nucleophilic charge distributions on the molecule. The 3D topology of the crystal packing is analyzed and interpreted via the energy‐framework simulation studies using CystalExplorer software. Through the In‐silico‐ADME calculations, the drug‐likeness and physicochemical properties of the molecule is predicted. Furthermore, the molecular docking studies are used to determine the bioactivity and anti‐diabetic properties of the title compound.

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The apoptotic efficacy of succinic acid on renal cancer cell lines

Cited by 11 publications

References 30 publications

Synergistic interactions of cytarabine-adavosertib in leukemic cell lines proliferation and metabolomic endpoints

Synergistic interactions of cytarabine-adavosertib in leukemic cell lines proliferation and metabolomic endpoints

Precision Tuning of Highly Selective Polyelectrolyte Membranes for Redox‐Mediated Electrochemical Separation of Organic Acids

DFT, Molecular Docking, Energy‐Framework, In‐silico ADME Analysis of 2,6‐Diamino‐4‐chloropyrimidine–succinic Acid (2/1)

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