Elodie Forest, Rémi Logeay, Charles Géminard, Diala Kantar, Florence Frayssinoux, Lisa Heron-Milhavet, Alexandre Djiane
Abstract:During development, cell proliferation is regulated, ensuring that tissues reach their correct size and shape. Forest et al. show that the Drosophila melanogaster scaffold protein big bang (Bbg) controls epithelial tissue growth without affecting epithelial polarity and architecture. Bbg interacts with spectrins at the apical cortex and promotes Yki signaling and actomyosin contractility.
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