The Antimicrobial Effect of Lactoferrin on Gram-Negative and Gram-Positive Bacteria

Jahani, Somayeh; Shakiba, Amin; Jahani, Leila

doi:10.17795/iji27594

Cited by 42 publications

(34 citation statements)

References 25 publications

(18 reference statements)

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“…According to Gasińska [ 38 ], lactoferrin exhibits antibacterial activity against streptococci, which is confirmed by the results of the present research. Such conclusions were also reached by Jahani et al [ 36 ], who claimed that lactoferrin had antibacterial effect on Streptococcus pyogenes, S. canis, S. agalactiae, Klebsiella pneumoniae, S. zooepidermicus , and Candidia albicans . Studies conducted by Ellison and Giehl [ 39 ] show that lactoferrin and lysozyme kill Gram-negative bacteria synergistically.…”

Section: Resultssupporting

confidence: 59%

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The Effect of Staphylococcus spp., Streptococcus spp. and Enterobacteriaceae on the Development of Whey Protein Levels and Oxidative Stress Markers in Cows with Diagnosed Mastitis

Puppel

Kalińska

Kot

et al. 2020

Animals

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Mastitis is one of the most common diseases of high-yielding dairy cows, and over 90% of cases are caused by Streptococcus spp., Enterobacteriaceae, or Staphylococcus spp. Certain groups of proteins are very significant in terms of the cow’s antioxidant, bacteriostatic, and germicidal properties: lysozyme (Lz), lactoferrin (Lf), and β-lactoglobulin (BLG). This study aimed to determine the influence of Staphylococcus spp., Streptococcus spp., and Enterobacteriaceae on the secretion of bioactive whey proteins and oxidative stress markers. From the herd, 60 multiparous cows with diagnosed mastitis were selected. Samples were taken individually from each quarter and pooled, which gave 60 samples. Enterobacteriaceae did not affect the BLG synthesis, whereas lysozyme and lactoferrin responded to a high concentration of these bacterial strains. In the case of Staphylococcus spp. infection, the BLG level increased. These strains did not affect the levels of di-malonic aldehyde (MDA), lactoferrin, and lysozyme. In contrast, they were significantly influenced by Streptococcus spp. In summary, the levels of whey proteins and oxidative stress markers changed depending on the bacterial strain inducing inflammation. Lysozyme and lactoferrin may be markers of udder inflammation caused by Enterobacteriaceae and Streptococcus spp., whereas β-lactoglobulin may prove useful in diagnosing Staphylococcus spp. induced mastitis.

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Section: Resultssupporting

confidence: 59%

“…According to Jahani et al [ 36 ], cows infected with Gram-negative bacteria have lower lysozyme activity than Gram-positive bacteria like, e.g., S. epidermidis and B. cereus . Andrzejczak [ 37 ] claims that this is due to the presence of Gram-negative bacteria, additional polypeptides, lipoproteins, and lipopolysaccharides in cell walls.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Staphylococcus spp., Streptococcus spp. and Enterobacteriaceae on the Development of Whey Protein Levels and Oxidative Stress Markers in Cows with Diagnosed Mastitis

Puppel

Kalińska

Kot

et al. 2020

Animals

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“…Lactoferrin is present in BM in high concentrations and protects the infant against pathogens through diverse modes of action. Lactoferrin chelates free iron, a necessary nutritional requirement for most bacterial pathogens, thus inhibiting the growth of a broad spectrum of bacteria [ 172 ]. In addition, partial digestion of lactoferrin leads to lactoferricin, a peptide with potent broad activity against bacteria, fungi, and viruses [ 173 , 174 , 175 ].…”

Section: Role Of Breast Milk On Microbiota and Immunity Maturationmentioning

confidence: 99%

Gut Microbiota and Mucosal Immunity in the Neonate

et al. 2018

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Gut microbiota colonization is a complex, dynamic, and step-wise process that is in constant development during the first years of life. This microbial settlement occurs in parallel with the maturation of the immune system, and alterations during this period, due to environmental and host factors, are considered to be potential determinants of health-outcomes later in life. Given that host–microbe interactions are mediated by the immune system response, it is important to understand the close relationship between immunity and the microbiota during birth, lactation, and early infancy. This work summarizes the evidence to date on early gut microbiota colonization, and how it influences the maturation of the infant immune system and health during the first 1000 days of life. This review will also address the influence of perinatal antibiotic intake and the importance of delivery mode and breastfeeding for an appropriate development of gut immunity.

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“…The third factor, described as "antimicrobial", was presented by the indexes of maintenance in serum blood cathelicidin (factor loading 0.810, RR 1.80, 95 % CI 1.25-2.62) and hBPI (factor loading 0.795, RR 1.75, 95 % CI 1.06-2.88) with total variation of 13.7. Data of Jahani S (2015) show that in the conditions of deficit of hBPI there is a decline of expression of cathelicidine LL37, lactoferrin and lysozyme, which, in turn, results in more considerable colonization of pathogenic microflora and can result in more severe course of the disease [19].…”

Section: Resultsmentioning

confidence: 99%

The prognostication of development of respiratory tract bacterial diseases for children of early age

2019

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A -research concept and design; B -collection and/or assembly of data; C -data analysis and interpretation; D -writing the article; E -critical revision of the article; F -final approval of the article The purpose of this study was definition of influence of the modified factors in development of acute pneumonia in children of early age and development of the method of prognostication of disease development.Materials and methods. 89 children of early age with acute bronchopulmonary pathology whose average age was 1.3 ± 0.2 years (47 children with acute bacterial bronchits and 42 children with acute community-acquired pneumonia) were examined. Also we tested the level of 25-hydroxyvitamin D (25(OH)D), hBPI, cathelicidin LL-37, lactoferrin in blood serum with the help of immunoenzymometric analysis. The significant factors that are most associated with the development of acute pneumonia were revealed using factor analysis. For prognostication of probability of development of an acute pneumonia the equation of logistic regression was used. Determination of quality of the received model of prognostication was conducted by means of the ROC analysis and index of AUC. For assessment of the discriminating ability of model the Gini index was calculated.Results. By results of conducted factor analysis 5 significant factors determining the main part of predictors of development of an acute pneumonia in children of early age, patients with acute inflammatory bronchopulmonary pathology were allocated. The conducted correlation analysis of variables revealed existence of interrelations between prenatal, anamnestic and immune factors which entered further mathematical model of probability of development of an acute pneumonia in children of early age. The statistical importance of the created model was confirmed by Omnibus Test, the diagnostic information content was estimated according to a ROC curve that confirmed high quality of model. Conclusion.On the basis of the conducted factor analysis the most priority predictors of development of an acute pneumonia in children of early age with acute bronchopulmonary pathology who were further included to the mathematical prognostic model of probability of development of the specified disease were allocated.Прогнозування розвитку бактеріальних захворювань органів дихання в дітей раннього віку Г. О. Леженко, А. В. Абрамов, Г. В. Крайня Мета роботи -визначення впливу модифікованих факторів у розвитку гострої пневмонії в дітей раннього віку та розроблення методу прогнозування розвитку захворювання.Матеріали та методи. Обстежили 89 дітей раннього віку з гострою бронхолегеневою патологією, середній вік яких становив 1,3 ± 0,2 року (47 дітей, які хворі на гострий бактеріальний бронхіт, і 42 дітей, які хворі на гостру позалікарняну пневмонію). За допомогою імуноферментного аналізу досліджували вміст у сироватці крові 25-гідроксивітаміну Д (25(ОН) D), hBPI, кателіцидину LL-37, лактоферину. За допомогою факторного аналізу виявили значущі фактори, що найбільше пов'язані з розвитком гострої пнев...

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The Antimicrobial Effect of Lactoferrin on Gram-Negative and Gram-Positive Bacteria

Cited by 42 publications

References 25 publications

The Effect of Staphylococcus spp., Streptococcus spp. and Enterobacteriaceae on the Development of Whey Protein Levels and Oxidative Stress Markers in Cows with Diagnosed Mastitis

The Effect of Staphylococcus spp., Streptococcus spp. and Enterobacteriaceae on the Development of Whey Protein Levels and Oxidative Stress Markers in Cows with Diagnosed Mastitis

Gut Microbiota and Mucosal Immunity in the Neonate

The prognostication of development of respiratory tract bacterial diseases for children of early age

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