The Antiinflammatory Effect of an Extract ofTripterygium wilfordii Hook F on Adjuvant-induced Paw Oedema in Rats and Inflammatory Mediators Release

Abstract

Tripterygium wilfordii Hook F(TWH), commonly known as the Thunder‐God‐Vine, is a popular remedy for rheumatism in southern China. In this study, we investigated the effect of T2 (an extract from TWH) on adjuvant‐induced paw oedema in rats and inflammatory mediators. The results showed that an intraperitoneal injection of T2 could significantly decrease the adjuvant‐induced paw oedema of rats. During in vitro study, lipopolysaccharide (LPS)‐stimulated human mononuclear prostaglandin E2 (PGE2) in the culture supernatant was significantly inhibited by T2 at a concentration of 2 μg/mL compared with the control group without T2 treatment (22352±4725 vs 43433±9014 pg/mL, p<0.05). When rat neutrophils were treated with 3 μg/mL of T2, the superoxide production was significantly lower than that of the group without T2 treatment (0.72±0.07 vs 1.37±0.04 nmol, p<0.05). T2 failed to suppress the β‐glucuronidase release from rat neutrophils but when the concentration was 30 μg/mL, it expressed a significant inhibition of lysozyme release (20.7±2.9 vs 38.2±4.0 in the control, p<0.05). The findings suggest this Chinese herb, like non‐steroid antiinflammatory drugs, expresses a potential antiinflammatory effect through its inhibition of PGE2 and superoxide function and lysozyme release. © 1997 by John Wiley & Sons, Ltd.

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