“…Clinical trials of clonidine have been reported from Europe (Bock et al, 1966;Frank and von Loewenich-Lagois, 1966;Grabncr et al, 1966;Kochsiek and Fritsche, 1966;Lieb and Ridders, 1966;Michel et al, 1966;Iisalo and Laurila, 1967), America (Davidov et al, 1967;Onesti et al, 1969;Smet et al, 1969), and Australasia (Ng et al, 1967;Raftos, 1969), and several workers have carried out acute haemodynamic studies (Barnett and Cantor, 1968;Muir et al, 1969). These show that clonidine lowers the blood pressure in all grades of hypertension, irrespective of posture.…”