The Antidiabetic and Antinephritic Activities of <i>Tuber melanosporum</i> via Modulation of Nrf2‐Mediated Oxidative Stress in the db/db Mouse

Jiang, Xue; Teng, Shanshan; Wang, Handong; Li, Shan; Zhang, Yaqin; Wang, Di

doi:10.1155/2018/7453865

Cited by 15 publications

(10 citation statements)

References 72 publications

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“…The up-regulation of MMP-9 and G-CSF prevents the development of DN (Wang et al, 2019). Hyperglycemia brings about mitochondrial superoxide overproduction and intracellular ROS accumulation, which may lead to the activation of inflammatory pathways (Jiang et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

The Hypoglycemic and Renal Protection Properties of Crocin via Oxidative Stress-Regulated NF-κB Signaling in db/db Mice

et al. 2020

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Background: As the main ingredient of Crocus sativus L. (Iridaceae) extract, crocin-I (CR) has been reported to show various pharmacological activities. The aim of this study was to investigate the hypoglycemic and renal protection properties of CR in db/db mice.Methods: Eight-week-old db/db mice were treated with metformin (Met) (100 mg/kg) and CR (50 mg/kg) for eight weeks.Results: CR treatment showed hypoglycemic functions indicated by reduced bodyweight, food and water intake, plasma glucose, and serum levels of glycated hemoglobin A1c. Additionally, the CR group showed increased serum levels of insulin and pyruvate kinase, hypolipidemic functions indicated by the suppressed levels of total cholesterol and triglyceride, and enhanced levels of high-density lipoprotein cholesterol, which are also indicators of hypoglycemic functions. The renal protection function of CR was demonstrated by its protection of renal structures and its regulation of potential indicators of nephropathy. The anti-oxidation and anti-inflammation effects of CR were verified by enzyme-linked immunosorbent assay. In the kidneys of db/db mice, CR decreased the expression of phospho-IkBa and phospho-nuclear factor-kB (NF-kB), whereas it enhanced the expression of nuclear respiratory factor 2, manganese superoxide dismutase 1, heme oxygenase-1, and catalase. Conclusions:The anti-diabetic and anti-diabetic nephritic effects of CR were related to its modulation of oxidative stress-mediated NF-kB signaling.

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Section: Discussionmentioning

confidence: 99%

The Hypoglycemic and Renal Protection Properties of Crocin via Oxidative Stress-Regulated NF-κB Signaling in db/db Mice

et al. 2020

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“…As a traditional folk medicine, black truffle has been used for adjunctive therapy of several diseases, such as eye ailments and gastric cancer [ 11 , 12 ]. However, fewer studies investigated the ability of black truffle in attenuating hyperlipidemia and inflammation in diabetic conditions [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Black Truffle Extract Exerts Antidiabetic Effects through Inhibition of Inflammation and Lipid Metabolism Regulation

Jayachandran

Cheang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Black truffle, a culinary and medical fungus, is highly valued worldwide for its nutritional and therapeutic importance. To enhance the existing knowledge about the beneficial properties, this study investigates the antioxidant, antihyperlipidemic, and anti-inflammatory effects of black truffle extract in in vitro biochemical assays and animal study. Briefly, black truffle extract was administered orally to treat streptozotocin- (STZ-) induced diabetic Wistar rats for 45 days. At the end of the experimental duration, rats were sacrificed to perform biochemical and gene expression analyses related to lipid regulatory and inflammatory pathways. Our results indicated that total cholesterol, triglycerides, free fatty acids, phospholipids, and low-density lipoprotein in different tissues and circulation were significantly increased in diabetic rats. Furthermore, the β-hydroxy β-methylglutaryl-CoA enzyme was also significantly increased; lipoprotein lipase and lecithin–cholesterol acyltransferase enzymes were significantly decreased in diabetic rats. However, the above conditions were reversed upon black truffle extract feeding. Furthermore, black truffle extract was also found to downregulate the expression of proinflammatory cytokines (tumor necrosis factor-α and interleukin-6) and lipid regulatory genes (serum regulatory element-binding protein-1 and fatty acid synthase). The truffle extract-treated effects were comparable to glibenclamide and medication commonly used to treat diabetes mellitus. Overall, our results suggested that black truffle possesses strong antihyperlipidemic and anti-inflammatory effects on diabetic rats. These findings will enhance the current knowledge about the therapeutic importance of black truffles. They might be exploited as a possible food supplement or even as a natural source of pharmaceutical agents for diabetes prevention and treatment.

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“…[85][86][87] In db/ db mice, the whole fruiting body of the black truffle Tuber melanosporum displayed hypoglycaemic, antioxidant and anti-inflammatory effects. 88,89 Clinical studies in pre-diabetic, diabetic and obese patients described positive effects of MED. A daily dose of 100 grams dried Agaricus bisporus, for 20 weeks, reduced oxidative stress and inflammation in T2DM patients, 90 while a combined powder of Pleurotus ostreatus and Pleurotus cystidiosus (50mg/kg/bw daily dose) treatment for 4 weeks decreased glucose levels and increased postprandial serum insulin levels.…”

Section: Box 3 Edibility Consumption and Health Benefits Of Mushrooms...mentioning

confidence: 99%

Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets

Fontes

Ramalho‐Santos

Zischka

et al. 2021

Eur J Clin Investigation

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Food and diet shaped human and nature histories. From the hunter-gathering communities to cooking with fire, to domesticating animals, planting crops and urbanization, to industrial revolutions, and to artificial intelligence, dietary habits influence human metabolism and consequently the condition of health and disease.Dietary habits from the Neolithic to the present, and the accompanying food production and processing procedures, have introduced some critical alterations in nutritional status, concerning glycaemic load, fatty acid, macronutrient, micronutrient or fibre content, acid-base balance, or sodium-potassium ratio, 1 leading to major shifts in metabolism traits. Although they also include heritable components, some of those traits like the high risk for obesity, 2 or non-alcoholic fatty liver disease (NAFLD) 3,4 (See Box 1), 4 a most important cause of liver disease, can be heavily affected by diet and other lifestyle conditions (e.g., sedentarism and sleep deprivation).Actually, over the last four decades, the rapid environmental changes contributed to the increase in mean body-mass index (BMI) and obesity, including among young people (ages 5 to 19 years) in most regions, 5 with important implications for public and global health.Dietary risk factors exacerbate metabolic risk factors 6 and the non-communicable diseases (NCD) mortality and morbidity, 7 that is, cardiovascular diseases (CVD), excess weight, obesity, type II diabetes mellitus (T2DM), cancer, neurodegenerative disorders and NAFLD. In 2017, around 22% of all deaths from NCD, among adults, were associated with dietary risk factors, representing a higher mortality risk than any other cause 7 ; such dietary risk factors include high levels of trans fat, sugary drinks, and high levels of red and processed meats, and vice versa, too low amounts of fruits, legumes, whole grains, nuts and seeds. 7 In 2018, the WHO estimated that NCD caused 71% of all deaths globally (41 million people per year). 8 Diet quality should cover variety and diversity, adequacy, moderation and balance; still, there are major gaps about defining diet quality, metrics for monitoring diet quality, and/or for diet quality monitoring in global

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The Antidiabetic and Antinephritic Activities of Tuber melanosporum via Modulation of Nrf2‐Mediated Oxidative Stress in the db/db Mouse

Cited by 15 publications

References 72 publications

The Hypoglycemic and Renal Protection Properties of Crocin via Oxidative Stress-Regulated NF-κB Signaling in db/db Mice

The Hypoglycemic and Renal Protection Properties of Crocin via Oxidative Stress-Regulated NF-κB Signaling in db/db Mice

Black Truffle Extract Exerts Antidiabetic Effects through Inhibition of Inflammation and Lipid Metabolism Regulation

Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets

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