The antidepressant-like effect of 7-fluoro-1,3-diphenylisoquinoline-1-amine in the mouse forced swimming test is mediated by serotonergic and dopaminergic systems

Pesarico, Ana Paula; Sampaio, Tuane Bazanella; Stangherlin, Eluza Curte; Mantovani, Anderson C.; Zeni, Gilson; Nogueira, Cristina W.

doi:10.1016/j.pnpbp.2014.06.001

Cited by 38 publications

(22 citation statements)

References 39 publications

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“…Moreover, in the current study post-treatment with FDPI at a dose of 10 mg/kg inhibited synaptosomal 5-HT uptake and did not alter MAO-A and MAO-B activities in the prefrontal cortices of non-stressed mice, and these results are in contrast with those obtained by us in another study, in which the administration with FDPI, at the same dose, decreased MAO-A and MAO-B activities but did not alter synaptosomal 5-HT uptake in mice [21]. The following reasons may explain these differences: (1) in the present study, all mice were submitted to the FST, while in the other study the animals did not perform the FST and (2) in this study, the mice were killed after the FST, while mice of the first study were killed exactly 30 min after FDPI administration.…”

Section: Discussioncontrasting

confidence: 99%

“…In addition, the results showed that post-treatment with FDPI decreased the total immobility time in the FST in non-stressed mice. Accordingly, the antidepressant-like action elicited by FDPI has been already shown by our research group [20,21]. By contrast, pre-treatment with FDPI did not elicit an antidepressant-like effect in the FST in non-stressed mice.…”

Section: Discussionsupporting

confidence: 61%

“…In this context, a series of 1-amino-isoquinoline derivatives has been shown to have an antioxidant action and has also been suggested as inhibitors of both isoforms of cerebral MAO activities in vitro [20]. Among the pharmacologically active compounds 7-fluoro-1,3-diphenylisoquinoline-1-amine (FDPI) has been reported to have an antidepressant-like action in mice and this action has been associated with an interaction with the monoaminergic system, more specifically serotonergic and dopaminergic systems [21].…”

Section: Introductionmentioning

confidence: 99%

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7-Fluoro-1,3-diphenylisoquinoline-1-amine abolishes depressive-like behavior and prefrontal cortical oxidative damage induced by acute restraint stress in mice

Pesarico

Stangherlin

Mantovani

et al. 2015

Physiology & Behavior

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

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7-Fluoro-1,3-diphenylisoquinoline-1-amine abolishes depressive-like behavior and prefrontal cortical oxidative damage induced by acute restraint stress in mice

Pesarico

Stangherlin

Mantovani

et al. 2015

Physiology & Behavior

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“…The apparatus was placed in a darkened and sound attenuated testing room. The total path of Spontaneous locomotive was evaluated over a 5 min period 51 , 52 .…”

Section: Methodsmentioning

confidence: 99%

Antidepressant-like effects and cognitive enhancement of Schisandra chinensis in chronic unpredictable mild stress mice and its related mechanism

Yan

Wan

et al. 2017

Sci Rep

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The aim of this study was to evaluate whether Schisandra chinensis extract (SCE) administration influences chronic unpredictable mild stress (CUMS)-induced depression and cognitive impairment, and explores underlying mechanisms. Sucrose preference test (SPT) and forced swimming test (FST) were used for assessing depressive symptoms, and Y-maze, Morris water maze were used for evaluating cognition processes. The results showed that CUMS (4 weeks) was effective in producing both depression and memory deficits in mice. Additionally, CUMS exposure significantly decreased brain derived neurotrophic factor (BDNF) levels in hippocampus as indicated by ELISA, immunohistochemistry and immunofluorescence assays, accompanied by down-regulated tyrosine kinase receptor B (TrkB)/cAMP-response element binding protein (CREB)/extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3 kinase (PI3K)/ protein kinase B (AKT)/ glycogen synthase kinase-3β (GSK-3β) signaling pathways. Chronic administration of SCE (600 or 1200 mg/kg, i.g.) significantly prevented all these CUMS-induced behavioral and biochemical alterations. It suggested that SCE could improve the depression-like emotional status and associated cognitive deficits in CUMS mice, which might be mediated by regulation of BDNF levels in hippocampus, as well as up-regulating of TrkB/CREB/ERK and PI3K/AKT/GSK-3β pathways.

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“…Behavioral assessment. With the purpose of excluding sedative or motor abnormality, the spontaneous locomotor activity was assessed (24). A clear acrylic chamber (11x11x15 cm), equipped with 12 infrared sensors for antomatic recording, was used.…”

Section: Submerged Fermentation Of Marasmius Androsaceusmentioning

confidence: 99%

Investigation of the antidepressant effects of exopolysaccharides obtained from Marasmius androsaceus fermentation in a mouse model

Song

Xing

Cao

et al. 2015

Molecular Medicine Reports

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Marasmius androsaceus, a well‑known medical fungus, possesses antihypertensive, analgesic and antioxidant effects. Exopolysaccharide (EPS), produced by microorganism secretion, exerts various types of biological activities. The present study aimed to investigate the antidepressant‑like effect of the EPS produced during Marasmius androsaceus submerge fermentation (MEPS). Based on the assessment of acute toxicity and behavior, a forced swimming test (FST), tail suspension test (TST), 5‑hydroxytryptophan‑induced head‑twitch assessment and reserpine‑induced hypothermia assessment were performed. The administration of MEPS for 7 days enhanced mouse locomotor and balance ability in the mice. Similar to the results following treatment with fluoxetine, which was used as positive control drug, MEPS significantly decreased the duration of immobility in the FST and TST, increased head twitches in the 5‑HTP‑induced head‑twitch test and enhanced rectal temperature in resperpine‑induced hypothermia. MEPS altered the abnormal concentrations of 5‑hydroxytryptamine, 5‑hydroxyindoleacetic acid, dopamine and norepinephrine in the hypothalamus in the resperine‑induced mouse model. Additionally, an increase in the expression of tyrosine hydroxylase and a reduction in the level of dopamine transporter in the hypothalamus were noted following 7 days of MEPS administration. Taken together, the EPS produced during MEPS exhibited antidepressant‑like effects, which may be associated with its regulation on the dopaminergic system. The results of the present study provide experimental evidence supporting the clinical use of MEPS as an effective agent against depression.

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The antidepressant-like effect of 7-fluoro-1,3-diphenylisoquinoline-1-amine in the mouse forced swimming test is mediated by serotonergic and dopaminergic systems

Cited by 38 publications

References 39 publications

7-Fluoro-1,3-diphenylisoquinoline-1-amine abolishes depressive-like behavior and prefrontal cortical oxidative damage induced by acute restraint stress in mice

7-Fluoro-1,3-diphenylisoquinoline-1-amine abolishes depressive-like behavior and prefrontal cortical oxidative damage induced by acute restraint stress in mice

Antidepressant-like effects and cognitive enhancement of Schisandra chinensis in chronic unpredictable mild stress mice and its related mechanism

Investigation of the antidepressant effects of exopolysaccharides obtained from Marasmius androsaceus fermentation in a mouse model

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