The anti-osteoporotic effect of Moringa oliefera on osteoblastic cells: SaOS 2

Patel, Chirag

doi:10.9790/3008-0521017

Cited by 12 publications

(9 citation statements)

References 20 publications

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“…9 Flavanoid compound serves as an anti-inflammatory, anti oxidants and osteoprotection. [10][11][12] Several other researchers even claim that Moringa oleifera plant can inhibit cyclooxygenase enzyme, prostaglandin synthesis and nitrous oxide production in macrophages cells induced by lipopolysacaride (LPS). 12,13 Tooth extraction can cause trauma triggering inflammation.…”

Section: Introductionmentioning

confidence: 99%

The effect of combined Moringa oleifera and demineralized freeze-dried bovine bone xenograft on the amount of osteoblast and osteoclast in the healing of tooth extraction socket of Cavia cobaya

Rostiny

Djulaeha

Hendrijantini

et al. 2016

Dent. J. (Majalah Kedokteran Gigi)

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Section: Introductionmentioning

confidence: 99%

The effect of combined Moringa oleifera and demineralized freeze-dried bovine bone xenograft on the amount of osteoblast and osteoclast in the healing of tooth extraction socket of Cavia cobaya

Rostiny

Djulaeha

Hendrijantini

et al. 2016

Dent. J. (Majalah Kedokteran Gigi)

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“…Most experiments confirmed ethanol extract upper hand. 6,7,17,18,[22][23][24][25][26][27][28] While, Kwon research confirmed superior results for water extract of moringa over ethanolic extract (Table 2). 16 Previous studies confirmed the tissue preservation of M. oleifera leaf ethanolic extracts, for example it protected rats against the hepatotoxicity of various drugs, 9 and increased cell proliferation and cell migration of human dermal fibroblasts.…”

Section: Discussionmentioning

confidence: 91%

Improvements of alveolar bone healing using Moringa oleifera leaf powder and extract biomimetic composite: an experimental study in dogs

Behairy

Ramadan²,

Rouby

et al. 2019

Egyptian Dental Journal

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Alveolar ridge preservation techniques and biomaterials were extensively used in the past few years. The rate of new bone formation is the concept in healing sockets. The faster the rate the lesser the alveolar bone resorption. Resorption is fastened in the first three months after extraction. Wide range of biomaterials were available, the choice of an ideal material was confusing. Objective: Evaluate the effectiveness of both Moringa Oleifera (MO) leaf powder and extract mixture locally and MO leaf extract repeated injections in fresh extraction sockets of dog. Moreover, identifying bioactive phenolic compounds in dried leaves. Materials and Methods: Eight mongrel dogs were included in this study; two animals were used as control. Six test animals were divided into two groups according to biopsy time (3 and 5 weeks). Each of these groups includes three animals. All animals were subjected to extraction of the third premolar bilaterally, both sides of the test animals (the six) were treated with Moringa Oleifera leaf powder (0.7 gm) and water extract (1ml) mixture. The right side only was subjected to repeated injections of Moringa Oleifera leaf water extract (½ ml) for two times (1 st week and 2 nd week postoperatively for all groups). Trephine bur was used to take biopsy for the purpose of histopathologic examination by H&E and Masson Trichrome stain to quantify new bone formation, and number of inflammatory cells. Results: Bone area percent showed the highest mean value in the right side at 3 weeks and 5 weeks. ANOVA test revealed no significant difference between groups (P=0.43) at 3 weeks, while the difference was significant at 5 weeks (P=0.00). Mean inflammatory cells count were significantly higher mean value in control group at 3 weeks and 5 weeks (P=0.00). Conclusion: Two injections of moringa oleifera aqueous extract of 11.7% concentration improved bone area present significantly at 5 weeks and decreased inflammatory cells at all test periods.

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“…This result is similar to the previous study which indicated that feeding of MOL to bilaterally ovariectomised rat can reduced bone loss (12) . Moreover, methanolic extracts of MO components were found to have significant osteoblast stimulating property on osteoblastic cells (13). Due to flavonoid in ethanolic extract of MOL could induce pMSCs derived from bone marrow to undergo osteogenic differentiation (14).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Moringa Oleifera Lam. Leaves Extract on Osteogenic Differentiation of Porcine Bone Marrow Derived Mesenchymal Stem Cells

2016

4th International Conference on Advances in Agricultural, Biological &Amp; Ecological Sciences (AABES-16) Dec. 1-2, 2016 London

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Abstract-Moringa oliefera Lam., the Asian herbal plant, has various uses, such as anti-oxidantion, and anti-inflammation. We have investigated the effect of Moringa oleifera Lam. leaves extract on osteogenic differentiation of porcine bone marrow derived mesenchymal stem cells. The potential of MSC for osteogenic differentiation has been well documented in many animal models especially on rodents. Despite the increasing importance of the pig as a large animal model. Previous studies have shown the benefits of Moringa oliefera leaves on anti-osteoporotic effect in osteoblastic cells. Therefore, this study aims to examine the effect of 100, 200, and 300ng/ml of ethanolic extract of Moringa oleifera Lam. leaves on osteogenic differentiation of porcine MSCs derived from bone marrow. The degree of osteogenic differentiation after Moringa oleifera Lam. leaves extract treatment was assessed by alkaline phosphatase (ALP) expression and ALP activity. The results showed that ethanolic extract of Moringa oleifera Lam. leaves enchanced osteogenic differentiation capacity of porcine bone marrow derived MSCs as demonstrated by increased ALP staining and ALP activity. The enhancement of osteogenic differentiation capacity of MSCs by those of Moringa oleifera Lam. leaves extract leads to the potential for using those for bone regeneration in pre-clinical models and bone alternative medicine.

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The anti-osteoporotic effect of Moringa oliefera on osteoblastic cells: SaOS 2

Abstract: M.oliefera oliefera (MO) is a middle-sized tree, cultivated throughout

Cited by 12 publications

References 20 publications

The effect of combined Moringa oleifera and demineralized freeze-dried bovine bone xenograft on the amount of osteoblast and osteoclast in the healing of tooth extraction socket of Cavia cobaya

The effect of combined Moringa oleifera and demineralized freeze-dried bovine bone xenograft on the amount of osteoblast and osteoclast in the healing of tooth extraction socket of Cavia cobaya

Improvements of alveolar bone healing using Moringa oleifera leaf powder and extract biomimetic composite: an experimental study in dogs

The Effects of Moringa Oleifera Lam. Leaves Extract on Osteogenic Differentiation of Porcine Bone Marrow Derived Mesenchymal Stem Cells

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