The anti-inflammatory potential of Cinnamomum camphora (L.) J.Presl essential oil in vitro and in vivo

Xiao, Shanshan; Yu, Hang; Xie, Yunfei; Guo, Yahui; Fan, Jiajia; Yao, Weirong

doi:10.1016/j.jep.2020.113516

Cited by 55 publications

(40 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2A). BEO signi cantly reduces expression of TNF-α in serum and tissues with xylene-induced auricular in ammation in mice [9], and its main component, borneol, can inhibit TNF-α and PTGS2 [21] production in tissues of mice with acute in ammations. Limonene has been reported to have anti-in ammatory effects by reducing the content of serum TNF-α and down-regulating the expression of NF-κB in in ammatory rats, and has been used in the treatment of acne [22].…”

Section: Discussionmentioning

confidence: 97%

“…The essential oil was dehydrated by adding anhydrous Na 2 SO 4 , and collected in a brown bottle, then stored at 4°C until future use. The BEO components were previously identi ed by our research group using gas chromatography mass spectrometry; BEO contains 43 components, the most abundant being borneol (16.4%) [9] (Table S1).…”

Section: Materials and Reagentsmentioning

confidence: 99%

“…The chemical composition of BEO was determined previously by our research group [9] (Table S1). Simpli ed Molecular Input Line Entry System (SMILES) strings of the components were obtained by searching the Traditional Chinese Medicine Integrated Database (http://www.megabionet.org/tcmid/) and imported into the Swiss Target Prediction database (STP; http://www.swisstargetprediction.ch/) to identify potential targets of BEO components.…”

Section: Network Pharmacology Analysismentioning

confidence: 99%

See 2 more Smart Citations

The Acne-treatment Potential of Cinnamomum Camphora Chvar. Borneol Essential Oil in Vitro and in Vivo

Xiao

Xie

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Acne is one of the most common chronic inflammatory skin diseases, abnormal proliferation of keratinocytes can block the hair follicle sebaceous glands result in the formation of acne. Most drugs to treat acne can cause a variety of side effects, therefore, it is important to seek natural and safe complementary and alternative therapies.Methods: The inhibitory effects of BEO were determined on the proliferation of human keratinocyte (HaCaT) cells induced by heat-inactivated Staphylococcus epidermidis and release of the inflammatory mediators. Further, a component-target-signal pathway for BEO’s effects on acne was constructed through network pharmacology and the mechanism of BEO action was studied in vivo through the rabbit ear acne model.Results: BEO inhibited both cell proliferation, induced by heat-inactivated Staphylococcus epidermidis (p < 0.0001), and release of the inflammatory mediators TNF-α (p < 0.0001) and IL-1β (p < 0.05) in a dose-dependent manner (r = -0.9952, -0.9492), in a HaCaT cell-model of acne. A network pharmacology analysis of the chemical components of BEO characterized these effects as multi-component, multi-target and multi-pathway. All targets were mainly associated with metabolic pathways, the toll-like receptor signaling pathway and the NF-κB signaling pathway. BEO also reduced the severity of acne lesions, induced by intracutaneous injection of S. epidermidis in a rabbit ear acne model. The expression of inflammatory mediators and key signaling pathway components, including TLR2, AKT, P13K, NF-κB, TNF-α, IL-1β in rabbit ear, and TNF-α and IL-1 β in serum, were down-regulated (p < 0.05), indicating that BEO acts by inhibiting the pro-inflammatory TLR2/PI3K-AKT/NF-κB signaling pathway.Conclusion: The current results showed that BEO has clear potential for development into a natural and safe anti-inflammatory skin preparation, which is an effective alternative to conventional treatments containing antibiotics and synthetic anti-inflammatory agents.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Materials and Reagentsmentioning

confidence: 99%

Section: Network Pharmacology Analysismentioning

confidence: 99%

See 1 more Smart Citation

The Acne-treatment Potential of Cinnamomum Camphora Chvar. Borneol Essential Oil in Vitro and in Vivo

Xiao

Xie

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Stabilization of the membrane of the human red blood cells inhibits lysis and subsequent release of the cytoplasmic contents which in turn limits tissue damage and exacerbation of the inflammatory response [38,39]. It is therefore expected that compounds with membrane stabilization activity should offer significant protection of cell membrane against injurious substances [40,41]. Methanol extract of C. albidum cotyledon showed less inhibition through 50 -350 µg/ml with percentage protection of 22.06 % -26.37 % compare to Ibuprofen with percentage protection of 35.47 % -54.40 %.…”

Section: Discussionmentioning

confidence: 99%

Assessment of In Vitro Antioxidant and Anti-Inflammatory Potentials of Methanol Extract of Chrysophyllum albidum Cotyledon

Dare

Elvis

2020

PAJOLS

View full text Add to dashboard Cite

Background: This study was aimed at analysing the phytochemicals in Chrysophyllum albidum cotyledon extract and their in vitro antioxidant and anti-inflammatory effects. Methods: The Chrysophyllum albidum cotyledon methanol extract (CCME) was phytochemically screened, and flavonoids and phenol contents, antioxidant and anti-inflammatory assays were carried out on the extract using standard procedures. Results: Phytochemicals analysis revealed the presence of steroids, tannins, flavonoid, saponin, triterpenes and xanthoproteins. The phenolic concentration, total flavonoids concentration and sugar concentration were found to be 26.720.048 μg of Tannic Acid Equivalent (TAE /mg, 23.121.92 μg of Rutin Equivalent (RTE)/mg (10.491.12 μg of Quercetin Equivalent (QE)/mg) and 778.3812.82 μg of glucose/ml respectively. The extract demonstrated significant (P<0.05) inhibitory effect compared with the standards as potent antioxidant with DPPH IC50 of 550.52 ± 82.83 μg/ml, lipid peroxidation (45.85 % – 65.85 %), Ferric reducing power showed linear correlation to the standard and the anti-inflammatory potential with (22.06 % – 26.37 %) percentage protection of the human red blood membrane stability and the percentage inhibition of denaturation of albumin (3.42 % – 7.32 %). Conclusion: The study showed that C. albidum cotyledon methanol extract is a potent antioxidant and anti-inflammatory agent to oxidative stress and pathological disease caused by reactive species.

show abstract

“…While in clinical and practical trials, essential oils are generally administered in a transdermal route. It has been demonstrated in several studies that transdermal administered essential oils are also able to produce anti-inflammatory effects on mice [ 42 , 43 ]. However, few studies evaluated the anxiolytic effects of essential oils by transdermal administration in animal studies.…”

Section: Introductionmentioning

confidence: 99%

Anxiolytic Effect of Two Tobacco Essential Oils (Nicotiana tabacum Linn.) on Mice

Xie

Yao

Huang³

et al. 2021

Molecules

View full text Add to dashboard Cite

Tobacco (Nicotiana tabacum Linn.) is a famous traditional herb used in folk medicine. The essential oils of tobacco have been demonstrated in modern studies to possess antioxidant, anti-inflammatory, and neuroprotective properties, while its anxiolytic effect has not been reported. The purpose of this study was to evaluate the anxiolytic effect of Yunnan tobacco essential oil (YTO) and Zimbabwe tobacco essential oil (ZTO) on mice. The constituents of YTO and ZTO were analyzed by GC/MS. The anxiolytic effect of YTO and ZTO (0.1%, 1%, and 10%, v/v) on male ICR mice was evaluated in the light–dark box test (LDB) and the elevated plus maze test (EPM) test via inhalation and transdermal administration. After the behavioral tests, salivary corticosterone levels in mice were measured. The behavioral analysis showed that the administration of both YTO and ZTO elevated the time that the mice spent in the light chamber in the LDB test compared to the untreated control. In the EPM test, YTO and ZTO increased the time spent in open arms and the number of entries into the open arms. In addition, both YTO and ZTO significantly decreased salivary corticosterone levels in mice (p ≤ 0.001). In summary, our results demonstrated that inhalation and transdermal administration of both YTO and ZTO showed anxiolytic effect on male ICR mice.

show abstract

The anti-inflammatory potential of Cinnamomum camphora (L.) J.Presl essential oil in vitro and in vivo

Cited by 55 publications

References 25 publications

The Acne-treatment Potential of Cinnamomum Camphora Chvar. Borneol Essential Oil in Vitro and in Vivo

The Acne-treatment Potential of Cinnamomum Camphora Chvar. Borneol Essential Oil in Vitro and in Vivo

Assessment of In Vitro Antioxidant and Anti-Inflammatory Potentials of Methanol Extract of Chrysophyllum albidum Cotyledon

Anxiolytic Effect of Two Tobacco Essential Oils (Nicotiana tabacum Linn.) on Mice

Contact Info

Product

Resources

About