The Anti-Inflammatory and Immunomodulatory Activity of Thymulin Peptide is NF-&amp;#954;B-Dependent and Involves the Downregulation of I&amp;#954;B-&amp;#945;

Haddad, John J.; Hanbali, Lama H.

doi:10.12691/ajmbr-1-2-2

Cited by 12 publications

(9 citation statements)

References 42 publications

(105 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Literature data testify to the regulatory effects of thymulin on the activity of macrophages, the differentiation and functioning of T-lymphocytes [18]. Animals with a model of neuroinflammation show the stimulating effect of this hormone on IL-10 synthesis in the brain against the suppression of the synthesis of TNF-α and IL-1β [29]. Macrophages and T-lymphocytes have been shown to be the source of proinflammatory cytokines and active forms of oxygen that damage nerve cells of the brain [3,11,30].…”

Section: Macrophages T-lymphocytes Markers Of Oxidative Stress and mentioning

confidence: 97%

The effects of interleukin-10 and fibroblasts growth factor-2 in mice with toxic cuprizone model of demyelination

Labunets¹,

Rodnichenko²,

Utko³

et al. 2019

JCOT

View full text Add to dashboard Cite

Cytokines and growth factors exhibit neurotropic, anti-inflammatory and immunomodulatory properties, and therefore can affect the functioning of the nervous system at demyelinating disorders.Purpose. To identify changes in T-lymphocytes, macrophages, oxidative stress and antioxidant defence factors, endocrine thymus function in the brain and behaviour of mice receiving neurotoxin cuprizone and recombinant human proteins: interleukin-10 (rhIL-10) and fibroblast growth factor (rhFGF-2).Materials and methods. 4-6-month-old 129/Sv mice received cuprizone with food every day for 3 weeks. From the 7th day of cuprizone diet, they received different doses of rhIL-10 and rhFGF-2. The content of СD3+ Т-cells, macrophages, malondialdehyde, activity of antioxidant enzymes in the brain and the level of thymulin in the blood were determined. Behavioural reactions were assessed in the “open field” test.Results. In the brain of mice receiving cuprizone and rhIL-10, there was a decrease in the number of СD3+ Т-cells and the activity of macrophages, which significantly increased under the influence of the toxin. After cytokine injection, the activity of superoxide dismutase, catalase and glutathione peroxidase increased significantly in the brain, as well as the level of thymulin in the blood. Motor, emotional and exploratory activity of mice, significantly suppressed by the cuprizone, was increased after the introduction of rhIL-10. The effect of rhIL-10 on the test parameters is more pronounced at a dose of 5 μg/kg than 50 μg/kg. After injection of rhFGF-2 in the mice with cuprizone diet, there is a decrease in the activity of brain macrophages and an increase of the level of thymulin in the blood depending on the dose of this factor; the motor activity of these animals increased regardless of the rhFGF-2 dose.Conclusion. The injections of rhIL-10 and rhFGF-2 provide dose-dependent positive effects on the pathogenetic factors of experimental demyelinating pathology, as well as the functional state of the nervous system. Whereas, the injections of rhIL-10 have more pronounced effects.

show abstract

Section: Macrophages T-lymphocytes Markers Of Oxidative Stress and mentioning

confidence: 97%

The effects of interleukin-10 and fibroblasts growth factor-2 in mice with toxic cuprizone model of demyelination

Labunets¹,

Rodnichenko²,

Utko³

et al. 2019

JCOT

View full text Add to dashboard Cite

show abstract

“…Efficacy of such thymulin influence was lesser in old organism [27]. Antiinflammatory effect of thymulin in the brain tissue (production of proinflammatory cytokines) plays role in the maintenance of neurogenesis [28].…”

Section: Thymulinmentioning

confidence: 99%

Age-Related Changes in the Melatonin and Thymulin Biorhythms as Risk Factors for Human Neurodegenerative Diseases

Labunets¹

2017

GGS

View full text Add to dashboard Cite

MelatoninNumerous studies suggest that melatonin is the main regulator of circadian and circannual rhythms both in mammals and humans CRIMSONpublishers http://www.crimsonpublishers.com Irina F Labunets* AbstractThe frequency of age-related neurodegenerative pathology, such as Parkinson's and Alzheimer's diseases, brain ischemia and multiple sclerosis increases worldwide and has great socio-economic implications. The use of approaches based on investigation the pathogenic factors of their development may be perspective in the prevention and treatment of such diseases.Circadian and circannual rhythms play a key role in the adaptative changes of human neuroendocrine and immune systems to the light and temperature. The rhythmicity of these systems is disturbed in human aging that may be connected with desynchronosis of pineal gland melatonin production. This process becomes more intensive during development of the neurodegenerative diseases.Thymic endocrine function (thymulin production) is the important part of chronobiological organization of immune system. The circadian and circannual rhythms of thymulin depend on the synchronizing influence of melatonin. Melatonin production disorders lead to the intra-immune desynchronosis via disturbances of the circadian and circannual rhythms of thymulin and its interactions with the endocrine glands (hypophysis, adrenal glands, gonads etc) both in aging and age pathology.Melatonin treatment improves sleep-wake rhythm and produces antiapoptotic, antioxidant and anti-inflammatory effects in the brain at neurodegenerative diseases and slows down development of this pathology. Moreover, melatonin treatment leads to the suppression of age-related changes in the rhythmicity of immune and neuroendocrine systems functions. Such melatonin effect is realized via synchronous influence on the circadian and circannual rhythms of thymulin production.Therefore melatonin seems to be perspective for restoring disturbed rhythmicity of immune and neuroendocrine systems in:A. accelerated human aging with pineal gland dysfunction and B. Patients of different age and sex suffering from neurodegenerative diseases making individual hormone dose correction.

show abstract

“…According to Oksimets et al [30], cytokines IL-1β, IL-2, IL-6, IL-8, TNF-α, which are secreted by transplanted MMSCs, play an important role in regulation of osteogenesis in injured limbs. The involvement of transcription factor NF-κB in implementation of thymulin effect in tissues in vivo and in vitro has been shown by altering the synthesis of proinflammatory (TNF-α, IL-1β, IL-6) and anti-inflammatory cytokines (IL-10) [31].…”

Section: Resultsmentioning

confidence: 99%

The effects of different doses of thymulin in vivo and in vitro on some biological properties of bone marrow-derived multipotent mesenchymal stromal cells in mice of different strains

Labunets¹,

Rodnichenko²

2018

COT

View full text Add to dashboard Cite

The Anti-Inflammatory and Immunomodulatory Activity of Thymulin Peptide is NF-κB-Dependent and Involves the Downregulation of IκB-α

Cited by 12 publications

References 42 publications

The effects of interleukin-10 and fibroblasts growth factor-2 in mice with toxic cuprizone model of demyelination

The effects of interleukin-10 and fibroblasts growth factor-2 in mice with toxic cuprizone model of demyelination

Age-Related Changes in the Melatonin and Thymulin Biorhythms as Risk Factors for Human Neurodegenerative Diseases

The effects of different doses of thymulin in vivo and in vitro on some biological properties of bone marrow-derived multipotent mesenchymal stromal cells in mice of different strains

Contact Info

Product

Resources

About