The Anti-Inflammatory Activity of Toonaciliatin K against Adjuvant Arthritis

Gou, HaiXing; Ye, Jie; Wang, YiRu; Xu, Xiaoli; Shen, Qixing; Xue, Jingwei; Zhao, Jie; Lu, Xianghua

doi:10.1155/2017/9436280

Cited by 10 publications

(6 citation statements)

References 50 publications

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“…The animals were weighed and monitored for clinical signs of arthritis every 3 days after the onset of secondary inflammation. The paw volume (the left hind paw), polyarthritis index and number of swollen digits were analysed using previously described methods …”

Section: Methodsmentioning

confidence: 99%

Evodiamine attenuates adjuvant-induced arthritis in rats by inhibiting synovial inflammation and restoring the Th17/Treg balance

Zhang

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Evodiamine (Evo) possesses strong anti-inflammatory activity. In this study, we determine the antiarthritic effect of Evo. Methods Evo was administered to rats with adjuvant-induced arthritis (AA). We evaluated arthritis symptoms & histopathological changes and measured inflammatory cell infiltration, pro-inflammatory cytokine production and Th17 & Treg percentages in arthritic rats. Key findings Evo significantly improved the clinical signs of AA in rats, including decreases in paw swelling, the polyarthritis index and the number of swollen paw joints. Based on the histopathological analysis, Evo improved synovial inflammation and bone injury by inhibiting inflammatory cell infiltration, synoviocyte proliferation, pannus formation and cartilage erosion. Furthermore, the numbers of synovial CD3+ or CD68+ inflammatory cells were reduced, and the elevated levels of tumour necrosis factor-a, interleukin-1b (IL-1b) and IL-6 were restored to control levels by the Evo treatment. In addition, Evo therapy regulated the abnormal differentiation of Treg and Th17 cells, decreasing IL-17 production and increasing IL-10 levels. Finally, Evo inhibited Stat3 phosphorylation and induced Stat5 phosphorylation in rats with AA. Conclusions Based on our results, Evo is a promising antiarthritic agent, potentially due to its inhibitory effect on synovial inflammation and regulatory effects on Treg and Th17 differentiation.

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Section: Methodsmentioning

confidence: 99%

Evodiamine attenuates adjuvant-induced arthritis in rats by inhibiting synovial inflammation and restoring the Th17/Treg balance

Zhang

et al. 2020

Journal of Pharmacy and Pharmacology

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“…The literature reveals that limonoids possess hepatoprotective, anti-inflammatory, anti-obesity, and anticancer activity [8][9][10][11]. Toonaciliatin K shows anti-inflammatory properties in several models including arthritis [12]. The present investigation determines the protective effect of toonaciliatin K against lung injury induced by lung infection of H1N1 influenza virus.…”

Section: Introductionmentioning

confidence: 78%

Toonaciliatin K attenuates the lung injury induced by lung infection of H1N1 influenza virus by regulating the NF-κB/MyD88/TLR-7 pathway in mice

Zeng¹,

Zhang²,

Wei³

2020

aoms

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Introduction: H1N1 infection has a high mortality rate due to lung injury and respiratory distress. The present study determines the protective effect of toonaciliatin K against the lung injury induced by the lung infection of H1N1 influenza mice and also postulates the molecular mechanism. Material and methods: Infection was induced by exposing the anesthetized mice to H1N1 virus (10 LD50 in a volume of 30 ml) intranasally at day zero and mice were treated with toonaciliatin K 16.5 and 33 mg/kg intragastrically for 2 weeks. The effect of toonaciliatin K was assessed by estimating survival rate and lung edema by the lung index. Histopathological changes were determined by H + E staining and western blot and an RT-PCR study was also performed on the lung tissue homogenate. Results: Data of the study suggest that toonaciliatin K treatment enhances the survival rate and reduces the lung index compared to infected mice. There was a decrease in the level of chemokines and cytokines in the lung tissue of the toonaciliatin K treated group compared to infected mice. Moreover, expression of TLR-7, NF-κB p65 and MyD88 protein was found to be reduced in the lung tissue of the toonaciliatin K treated group compared to infected mice. Conclusions: Data of the study suggested that toonaciliatin K protects against lung injury in lung H1N1 lung infection by regulating the TLR-7/ Myd88/NF-κB p65 pathway.

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“…The most prevalent molecular target in the treatment of RA is the suppression of inflammatory cytokines. 27 Significant radiological changes, such as bone erosion and joint space constriction were reversed in treatment groups.…”

Section: Discussionmentioning

confidence: 94%

Synergistic Effect of Different Extracts of Asparagus officinalis (Asparagaceae), Garcinia travancorica (Clusiaceae) and Mucuna gigantea (Fabaceae) Extracts on Analgesic, Anti-inflammatory and Anti-arthritic Activities in Rats

Kumar

Srivastava²,

Gupta

2023

J. Young Pharm.

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Background:The arial part of Asparagus officinalis (A.O.) (Family: Asparagus) stem and seeds, leaf parts of Mucuna gigantea (M.G.) (Family: Fabaceae) and fruit rinds and arial part of Garcinia travancorica (G.T.) (Family: Clusiaceae) have long been used to treat joint pain. However, its preclinical efficacy for rheumatoid arthritis has not been pharmacologically evaluated. In the current study, extracts of A.O., M.G., and G.T. from petroleum ether, ethanolic extract, and aqueous extract were examined for their analgesic, anti-inflammatory, anti-arthritic, and phytochemical properties. Materials and Methods: Rats' tail flick method was used to assess analgesic activity, carrageenan-induced paw oedema model was used to assess anti-inflammatory activity, and protein Complete Freund's Adjuvant (CFA)-induced arthritis model was used to assess anti-arthritic potential. Results: We observed that many extracts had anti-inflammatory and anti-arthritic effects, and to a lesser extent, analgesic activities corresponding to the administered dose. The CFA model's findings showed improved defence against arthritic lesions and changes in body weight. Additionally, rheumatoid factor, altered WBCs count, and histological and radiographic changes were all markedly improved by M.G., G.T., and A.O. Conclusion: All the three plants extract when given together, supports traditional combinatorial use of M.G., G.T. and A.O. as potent analgesic, a potential anti-inflammatory and anti-arthritic polypharmacy for the treatment of rheumatoid arthritis.

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The Anti-Inflammatory Activity of Toonaciliatin K against Adjuvant Arthritis

Cited by 10 publications

References 50 publications

Evodiamine attenuates adjuvant-induced arthritis in rats by inhibiting synovial inflammation and restoring the Th17/Treg balance

Evodiamine attenuates adjuvant-induced arthritis in rats by inhibiting synovial inflammation and restoring the Th17/Treg balance

Toonaciliatin K attenuates the lung injury induced by lung infection of H1N1 influenza virus by regulating the NF-κB/MyD88/TLR-7 pathway in mice

Synergistic Effect of Different Extracts of Asparagus officinalis (Asparagaceae), Garcinia travancorica (Clusiaceae) and Mucuna gigantea (Fabaceae) Extracts on Analgesic, Anti-inflammatory and Anti-arthritic Activities in Rats

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