The analysis of organ weight data

An Autopsy Study of the Quantitative Anatomy of Human Heart

“…We do not have any significant data for individuals after the age of 65 as those were excluded from the study. These findings were compatible with some previous studies [30][31][32] while not in keeping with certain other studies [26]. In one study based on Japanese populations, it was evident that the heart weight increases with age up to 90 years and only there after starts to decrease [33].…”

“…Heart weight tends to increase with the body weight in both sexes. It was compatible with several studies conducted in Japan [30], China [31] and India [32] while being inconsistent with certain other studies. Some studies highlight that heart weight is independent on body weight [29].…”

“…1 and 2). It was compatible with some studies conducted in Japan [30], China [31], India [32] and Mayo Clinic [35,36] while inconsistent with certain other studies [26]. Some studies highlight that the heart weight is independent of the body length/height [26], though it was dependent upon the body mass index [29] or the body surface area [26].…”

An Autopsy Study of the Quantitative Anatomy of Human Heart

“…We do not have any significant data for individuals after the age of 65 as those were excluded from the study. These findings were compatible with some previous studies [30][31][32] while not in keeping with certain other studies [26]. In one study based on Japanese populations, it was evident that the heart weight increases with age up to 90 years and only there after starts to decrease [33].…”

“…Heart weight tends to increase with the body weight in both sexes. It was compatible with several studies conducted in Japan [30], China [31] and India [32] while being inconsistent with certain other studies. Some studies highlight that heart weight is independent on body weight [29].…”

“…1 and 2). It was compatible with some studies conducted in Japan [30], China [31], India [32] and Mayo Clinic [35,36] while inconsistent with certain other studies [26]. Some studies highlight that the heart weight is independent of the body length/height [26], though it was dependent upon the body mass index [29] or the body surface area [26].…”

Relationships Between Organ Weight and Body/Brain Weight in the Rat: What Is the Best Analytical Endpoint?

“…This potential for error in evaluating the effects of chemicals on the weights of adrenal glands and other organs has been reported in many previous reports (Angervall and Carlström, 1963;Setnikar and Magistretti, 1965;Krames and Van Liere, 1966;Dikstein et al, 1967;Feron et al, 1973;Stevens, 1976Stevens, , 1977Trieb et al, 1976;Schärer, 1977;Shirley, 1977Shirley, , 1982Takizawa, 1978;Hutson et al, 1981; TOXICOLOGIC PATHOLOGY Uemitsu et al, 1984;Brown et al, 1985;Salsburg, 1986;Famula et al, 1988). In the cases where the organ-to-body weight relationship does not justify the analysis of ratio values, several alternative methods have been suggested.…”

Determining organ weight toxicity with Bayesian causal models: Improving on the analysis of relative organ weights

“…The relative organ weights are then plotted, analysed, and interpreted, and researchers assume that this approach will provide correct conclusions. Unfortunately, the ratio fails to properly adjust for differences in body weight between groups -a point made repeatedly but mostly ignored [1][2][3][4][5][6][7][8][9] , and which we demonstrate again below.…”

An Autopsy Study of the Quantitative Anatomy of Human Heart

“…We do not have any significant data for individuals after the age of 65 as those were excluded from the study. These findings were compatible with some previous studies [30][31][32] while not in keeping with certain other studies [26]. In one study based on Japanese populations, it was evident that the heart weight increases with age up to 90 years and only there after starts to decrease [33].…”

“…Heart weight tends to increase with the body weight in both sexes. It was compatible with several studies conducted in Japan [30], China [31] and India [32] while being inconsistent with certain other studies. Some studies highlight that heart weight is independent on body weight [29].…”

“…1 and 2). It was compatible with some studies conducted in Japan [30], China [31], India [32] and Mayo Clinic [35,36] while inconsistent with certain other studies [26]. Some studies highlight that the heart weight is independent of the body length/height [26], though it was dependent upon the body mass index [29] or the body surface area [26].…”

Relationships Between Organ Weight and Body/Brain Weight in the Rat: What Is the Best Analytical Endpoint?

“…This potential for error in evaluating the effects of chemicals on the weights of adrenal glands and other organs has been reported in many previous reports (Angervall and Carlström, 1963;Setnikar and Magistretti, 1965;Krames and Van Liere, 1966;Dikstein et al, 1967;Feron et al, 1973;Stevens, 1976Stevens, , 1977Trieb et al, 1976;Schärer, 1977;Shirley, 1977Shirley, , 1982Takizawa, 1978;Hutson et al, 1981; TOXICOLOGIC PATHOLOGY Uemitsu et al, 1984;Brown et al, 1985;Salsburg, 1986;Famula et al, 1988). In the cases where the organ-to-body weight relationship does not justify the analysis of ratio values, several alternative methods have been suggested.…”

Determining organ weight toxicity with Bayesian causal models: Improving on the analysis of relative organ weights

“…The relative organ weights are then plotted, analysed, and interpreted, and researchers assume that this approach will provide correct conclusions. Unfortunately, the ratio fails to properly adjust for differences in body weight between groups -a point made repeatedly but mostly ignored [1][2][3][4][5][6][7][8][9] , and which we demonstrate again below.…”

An Autopsy Study of the Quantitative Anatomy of Human Heart

“…We do not have any significant data for individuals after the age of 65 as those were excluded from the study. These findings were compatible with some previous studies [30][31][32] while not in keeping with certain other studies [26]. In one study based on Japanese populations, it was evident that the heart weight increases with age up to 90 years and only there after starts to decrease [33].…”

“…Heart weight tends to increase with the body weight in both sexes. It was compatible with several studies conducted in Japan [30], China [31] and India [32] while being inconsistent with certain other studies. Some studies highlight that heart weight is independent on body weight [29].…”

“…1 and 2). It was compatible with some studies conducted in Japan [30], China [31], India [32] and Mayo Clinic [35,36] while inconsistent with certain other studies [26]. Some studies highlight that the heart weight is independent of the body length/height [26], though it was dependent upon the body mass index [29] or the body surface area [26].…”

Relationships Between Organ Weight and Body/Brain Weight in the Rat: What Is the Best Analytical Endpoint?

“…This potential for error in evaluating the effects of chemicals on the weights of adrenal glands and other organs has been reported in many previous reports (Angervall and Carlström, 1963;Setnikar and Magistretti, 1965;Krames and Van Liere, 1966;Dikstein et al, 1967;Feron et al, 1973;Stevens, 1976Stevens, , 1977Trieb et al, 1976;Schärer, 1977;Shirley, 1977Shirley, , 1982Takizawa, 1978;Hutson et al, 1981; TOXICOLOGIC PATHOLOGY Uemitsu et al, 1984;Brown et al, 1985;Salsburg, 1986;Famula et al, 1988). In the cases where the organ-to-body weight relationship does not justify the analysis of ratio values, several alternative methods have been suggested.…”

Determining organ weight toxicity with Bayesian causal models: Improving on the analysis of relative organ weights

“…The relative organ weights are then plotted, analysed, and interpreted, and researchers assume that this approach will provide correct conclusions. Unfortunately, the ratio fails to properly adjust for differences in body weight between groups -a point made repeatedly but mostly ignored [1][2][3][4][5][6][7][8][9] , and which we demonstrate again below.…”