2006
DOI: 10.1038/sj.mp.4001869
|View full text |Cite|
|
Sign up to set email alerts
|

Abstract: Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studies have demonstrated the importance of genetic factors and candidate gene association studies have identified several loci that exert small but significant effects on ADHD. To provide further clarification of reported associations and identify novel associated genes, we examined 1038 single-nucleotide polymorphisms (SNP… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

16
488
7
6

Year Published

2007
2007
2016
2016

Publication Types

Select...
5
3

Relationship

0
8

Authors

Journals

citations
Cited by 487 publications
(517 citation statements)
references
References 82 publications
16
488
7
6
Order By: Relevance
“…84,85 In this respect, the combined subtype may represent a distinctive and more homogeneous phenotype that could facilitate the identification of genetic factors contributing to ADHD. However, Brookes et al 73 exhaustively investigated 32 markers within this candidate gene (including rs2770296, rs1328684, rs6561333 and rs7322347, which showed nominal significant P-values in our sample) in 776 combined ADHD cases and found no evidence of association, which disagreed with our findings. These discrepant results could be explained by differences in study design (TDT in Brookes et al and case-control in our study) or between the populations under study (Brookes et al recruited patients from eight different countries, whereas our study is based on patients from Spain).…”
Section: Ht2acontrasting
confidence: 99%
See 2 more Smart Citations
“…84,85 In this respect, the combined subtype may represent a distinctive and more homogeneous phenotype that could facilitate the identification of genetic factors contributing to ADHD. However, Brookes et al 73 exhaustively investigated 32 markers within this candidate gene (including rs2770296, rs1328684, rs6561333 and rs7322347, which showed nominal significant P-values in our sample) in 776 combined ADHD cases and found no evidence of association, which disagreed with our findings. These discrepant results could be explained by differences in study design (TDT in Brookes et al and case-control in our study) or between the populations under study (Brookes et al recruited patients from eight different countries, whereas our study is based on patients from Spain).…”
Section: Ht2acontrasting
confidence: 99%
“…Specifically, we aimed to address the following issues: (1) identify genetic susceptibility factors involved in ADHD in the serotoninergic neurotransmission system; (2) test the existence of common genetic factors in childhood and adulthood ADHD; and (3) 73 Interestingly, functional brain imaging studies showed evidence of altered DDC activity in children and adults with ADHD, also suggesting that DDC is a susceptibility factor common to both adulthood and childhood ADHD. 74,75 …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Overweight and obesity seem to be more prevalent among persons with mental disorder 29 and children with ADHD symptoms. 30,31 ADHD has been mainly linked to dysfunction in dopaminergic and serotonergic systems in genetic studies 32 and recently some evidence points to dysfunctions in the same systems among overweight and obese women. 33,34 Thus, genetic predisposition could account for both overweight and ADHD symptoms.…”
Section: Possible Mechanismsmentioning
confidence: 99%
“…The 3 0 VNTR shows strong linkage disequilibrium (LD) with variants in exons 9-15, but there is no reported with haplotypes in the first exons or the 5 0 flanking region. 39,40 A recent publication 41 described the investigation of 32 SNPs in the genomic region of DAT1 in a sample of 663 families with at least one offspring with ADHD combined type (Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV)). They defined four haplotype blocks (HB): HB1: promoter-intron 2, HB2: intron 2-exon 8, HB3: intron 8-intron 13 and HB4: 3 0 UTR.…”
Section: Introductionmentioning
confidence: 99%