The alteration of drug metabolism enzymes and pharmacokinetic parameters in nonalcoholic fatty liver disease: current animal models and clinical practice

17β-Estradiol protects female rats from bilateral oophorectomy-induced nonalcoholic fatty liver disease induced by improving linoleic acid metabolism alteration and gut microbiota disturbance

“…E 2 treatment promoted Cyp3a9 mRNA expression not only in our research [ 71 ]. The expression level of Cyp1a2 was not entirely consistent between C57BL/6 mice and ob/ob mice [ 72 ]. The results from ob/ob mouse models showed that the mRNA expression, protein level, and activity of Cyp1a2 were significantly decreased [ 73 ], and the same changes could be seen in HFD-induced obese rats [ 74 ].…”