The Allograft Rejection Reaction: The Leading Cause of Late Failure of Clinical Corneal Grafts

Topical Cyclosporine A in Corneal Graft Rejection

“…In our study, the rejection reversal rate of 90% in CSA group and 70% in non CSA group were slightly higher than the studies in which reversal rates were between 50% and 75.9% [3,39] ; however, the difference was not statistically significant(P value =0.21). In contrast, we found that addition of CSA is significantly beneficial in shortening the duration of rejection reversal (P value=0.001).…”

Topical Cyclosporine A in Corneal Graft Rejection

“…In our study, the rejection reversal rate of 90% in CSA group and 70% in non CSA group were slightly higher than the studies in which reversal rates were between 50% and 75.9% [3,39] ; however, the difference was not statistically significant(P value =0.21). In contrast, we found that addition of CSA is significantly beneficial in shortening the duration of rejection reversal (P value=0.001).…”

Outcome of optical penetrating keratoplasties at a tertiary care eye institute in Western India

“…Prior graft failure as a risk factor in subsequent grafts is a well-known fact established by Khodadoust, where rejection rate of 40% after first graft, 68% after second, and 80% after third graft was found. [ 17 ] We did not find statistically significant correlation between surgical factors like graft size, PK, and PK with associated procedure with graft survival. This is perhaps due to the fact that like most other reputed centers, we follow well-established practice patterns of surgical and postoperative treatment.…”

Different Influences on Corneal Graft Survival in 539 Transplants

“…Another known negative influence on the corneal graft survival rate, the degree of vascularization (Khodadoust 1973;Batchelor 1976), was also found to be statistically significant. Since graft failures attract blood vessel in ingrowth, those 2 negative influences are not mutually exclusive.…”

“…The negative influence of previous graft failures on graft survival rates as suggested by the work of Gibbs (1974) and Khodadoust (1979) could be demonstrated to be statistically significant in the whole material of 539 grafts as well as in the group of vascularized corneas only. Another known negative influence on the corneal graft survival rate, the degree of vascularization (Khodadoust 1973;Batchelor 1976), was also found to be statistically significant. Since graft failures attract blood vessel in ingrowth, those 2 negative influences are not mutually exclusive.…”

Topical Cyclosporine A in Corneal Graft Rejection

“…In our study, the rejection reversal rate of 90% in CSA group and 70% in non CSA group were slightly higher than the studies in which reversal rates were between 50% and 75.9% [3,39] ; however, the difference was not statistically significant(P value =0.21). In contrast, we found that addition of CSA is significantly beneficial in shortening the duration of rejection reversal (P value=0.001).…”

Outcome of optical penetrating keratoplasties at a tertiary care eye institute in Western India

“…Prior graft failure as a risk factor in subsequent grafts is a well-known fact established by Khodadoust, where rejection rate of 40% after first graft, 68% after second, and 80% after third graft was found. [ 17 ] We did not find statistically significant correlation between surgical factors like graft size, PK, and PK with associated procedure with graft survival. This is perhaps due to the fact that like most other reputed centers, we follow well-established practice patterns of surgical and postoperative treatment.…”

Different Influences on Corneal Graft Survival in 539 Transplants

“…Another known negative influence on the corneal graft survival rate, the degree of vascularization (Khodadoust 1973;Batchelor 1976), was also found to be statistically significant. Since graft failures attract blood vessel in ingrowth, those 2 negative influences are not mutually exclusive.…”

“…The negative influence of previous graft failures on graft survival rates as suggested by the work of Gibbs (1974) and Khodadoust (1979) could be demonstrated to be statistically significant in the whole material of 539 grafts as well as in the group of vascularized corneas only. Another known negative influence on the corneal graft survival rate, the degree of vascularization (Khodadoust 1973;Batchelor 1976), was also found to be statistically significant. Since graft failures attract blood vessel in ingrowth, those 2 negative influences are not mutually exclusive.…”

Topical Cyclosporine A in Corneal Graft Rejection

“…In our study, the rejection reversal rate of 90% in CSA group and 70% in non CSA group were slightly higher than the studies in which reversal rates were between 50% and 75.9% [3,39] ; however, the difference was not statistically significant(P value =0.21). In contrast, we found that addition of CSA is significantly beneficial in shortening the duration of rejection reversal (P value=0.001).…”

Outcome of optical penetrating keratoplasties at a tertiary care eye institute in Western India

“…Prior graft failure as a risk factor in subsequent grafts is a well-known fact established by Khodadoust, where rejection rate of 40% after first graft, 68% after second, and 80% after third graft was found. [ 17 ] We did not find statistically significant correlation between surgical factors like graft size, PK, and PK with associated procedure with graft survival. This is perhaps due to the fact that like most other reputed centers, we follow well-established practice patterns of surgical and postoperative treatment.…”

Different Influences on Corneal Graft Survival in 539 Transplants

“…Another known negative influence on the corneal graft survival rate, the degree of vascularization (Khodadoust 1973;Batchelor 1976), was also found to be statistically significant. Since graft failures attract blood vessel in ingrowth, those 2 negative influences are not mutually exclusive.…”

“…The negative influence of previous graft failures on graft survival rates as suggested by the work of Gibbs (1974) and Khodadoust (1979) could be demonstrated to be statistically significant in the whole material of 539 grafts as well as in the group of vascularized corneas only. Another known negative influence on the corneal graft survival rate, the degree of vascularization (Khodadoust 1973;Batchelor 1976), was also found to be statistically significant. Since graft failures attract blood vessel in ingrowth, those 2 negative influences are not mutually exclusive.…”