2009
DOI: 10.1371/journal.pmed.1000050
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Abstract: Philip Brooks and colleagues discuss evidence linking the alcohol flushing response (predominantly due to ALDH2 deficiency) with a much higher risk of esophageal cancer from alcohol consumption.

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Cited by 379 publications
(377 citation statements)
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“…48 The long-term effects of acetaldehyde on esophageal cancer are also established. 22,49 However, the long-term direct effect of acetaldehyde on coronary atherosclerosis is not well understood. If this long-term direct effect is meaningful, alcohol flushing cannot be used as an IV.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…48 The long-term effects of acetaldehyde on esophageal cancer are also established. 22,49 However, the long-term direct effect of acetaldehyde on coronary atherosclerosis is not well understood. If this long-term direct effect is meaningful, alcohol flushing cannot be used as an IV.…”
Section: Discussionmentioning
confidence: 99%
“…21 The alcohol flushing response, also called Asian flush or Asian glow, is associated with high acetaldehyde levels and predominantly results from an inherited deficiency in the ALDH2 enzyme among East Asians. 22 Questions about alcohol flushing have been used to identify ALDH2-deficient subjects and have been found to be highly reliable in detecting subjects with inactive ALDH2 in East Asian countries, 23,24 including South Korea. 25 Alcohol flushing can be used as a proxy for ALDH2 genetic variation.…”
Section: Introductionmentioning
confidence: 99%
“…However, it is notable that some ALDH2 *2(+) carriers reported consuming higher amounts of ethanol per month ( M = 152.96 and 134.00, respectively, at the most and all friends got drunk levels). Even light drinking levels for this group could have the potential for later health consequences because of the association between acetaldehyde (a toxin) and esophageal cancer (33). It is likely, based on earlier studies, that these students are not drinking one drink nightly over the month but instead are drinking at higher rates during the weekend or other social engagements (28,34).…”
Section: Discussionmentioning
confidence: 99%
“…The first included ALDH2 *2(−) carriers who were highly exposed to their peers’ alcohol use, and the second included ALDH2 *2(+) carriers who, while they could be defined as light drinkers, are still at a greater risk for some cancers. The risky drinking level of these ALDH2 *2(+) carriers may be related to social media reports about the use of over-the-counter medications to dampen the flushing reaction in order to continue drinking (33), as well as the perception by some Asian college students, especially among males, that the flushing reaction provides no special warning about how much they should drink (46). Risky drinking levels for ALDH2 *2(−) carriers may point to a weakening of known cultural protections against drinking for Asian-American youth at this high level of peer drunkenness (35,36).…”
Section: Discussionmentioning
confidence: 99%
“…Because students would have received their results from a computer screen instead of an individual, there was no way to assess or monitor an individual's response to the information, or to be able to clarify any misunderstandings about the meaning of the information. Furthermore, the aldehyde dehydrogenase 2 polymorphism that was examined in this program has been associated with increased esophageal cancer susceptibility in Southeast Chinese males [34], a factor either denied or missed by the authors of the study and the members of the institutional review board. There were also concerns about the confidentiality of the responses.…”
Section: In the Classroommentioning
confidence: 99%