The adrenocorticotropic hormone (ACTH)-induced reversal of hemorrhagic shock

Cardiovascular effects of H3 histamine receptor inverse agonist/ H4 histamine receptor agonist, clobenpropit, in hemorrhage-shocked rats

“…in the liver, spleen and large veins. Such action was shown previously in relation to the histamine [ 16 ], ACTH [ 15 ] and leptin effects [ 17 ] in hemorrhagic shock.…”

Cardiovascular effects of H3 histamine receptor inverse agonist/ H4 histamine receptor agonist, clobenpropit, in hemorrhage-shocked rats

“…in the liver, spleen and large veins. Such action was shown previously in relation to the histamine [ 16 ], ACTH [ 15 ] and leptin effects [ 17 ] in hemorrhagic shock.…”

Influence of ACTH‐(1–24) on free radical levels in the blood of haemorrhage‐shocked rats: direct ex vivo detection by electron spin resonance spectrometry

“…This effect of ACTH-(1-24) is prompt (reaching its maximum 15 min after treatment) and long-lasting (the free radical blood level remains quite stable throughout the 2 h observation period). It parallels the effects of ACTH-(1-24) on arterial pressure and tissue blood flow (Bertolini et al, 1989;Guarini et al, 1989). This effect cannot be attributed to an ACTH-(1-24) radical scavenging activity, as demonstrated by the competition experiment.…”

Albumin Saturated With Fatty Acids Prevents Decompensation in a Rat Hemorrhagic Shock Trauma Model With Tourniquet and Hypotensive Resuscitation

“…This was unsustainable, however, and DAP would plummet without a change in HR or PP, suggesting a sudden loss of venous return due to sympathetic signaling failure. Sudden drops in sympathetic signaling occur after hemorrhage in rabbits, supporting this hypothesis (8, 28, 29). After 2 to 3 h of occlusion, the remaining animals would start slowly decreasing pressure until death, suggesting the sympathetic signal was present but decreasing or the vasculature was losing the ability to respond.…”

Cardiovascular effects of H3 histamine receptor inverse agonist/ H4 histamine receptor agonist, clobenpropit, in hemorrhage-shocked rats

“…in the liver, spleen and large veins. Such action was shown previously in relation to the histamine [ 16 ], ACTH [ 15 ] and leptin effects [ 17 ] in hemorrhagic shock.…”

Influence of ACTH‐(1–24) on free radical levels in the blood of haemorrhage‐shocked rats: direct ex vivo detection by electron spin resonance spectrometry

“…This effect of ACTH-(1-24) is prompt (reaching its maximum 15 min after treatment) and long-lasting (the free radical blood level remains quite stable throughout the 2 h observation period). It parallels the effects of ACTH-(1-24) on arterial pressure and tissue blood flow (Bertolini et al, 1989;Guarini et al, 1989). This effect cannot be attributed to an ACTH-(1-24) radical scavenging activity, as demonstrated by the competition experiment.…”

Albumin Saturated With Fatty Acids Prevents Decompensation in a Rat Hemorrhagic Shock Trauma Model With Tourniquet and Hypotensive Resuscitation

“…This was unsustainable, however, and DAP would plummet without a change in HR or PP, suggesting a sudden loss of venous return due to sympathetic signaling failure. Sudden drops in sympathetic signaling occur after hemorrhage in rabbits, supporting this hypothesis (8, 28, 29). After 2 to 3 h of occlusion, the remaining animals would start slowly decreasing pressure until death, suggesting the sympathetic signal was present but decreasing or the vasculature was losing the ability to respond.…”

Cardiovascular effects of H3 histamine receptor inverse agonist/ H4 histamine receptor agonist, clobenpropit, in hemorrhage-shocked rats

“…in the liver, spleen and large veins. Such action was shown previously in relation to the histamine [ 16 ], ACTH [ 15 ] and leptin effects [ 17 ] in hemorrhagic shock.…”

Influence of ACTH‐(1–24) on free radical levels in the blood of haemorrhage‐shocked rats: direct ex vivo detection by electron spin resonance spectrometry

“…This effect of ACTH-(1-24) is prompt (reaching its maximum 15 min after treatment) and long-lasting (the free radical blood level remains quite stable throughout the 2 h observation period). It parallels the effects of ACTH-(1-24) on arterial pressure and tissue blood flow (Bertolini et al, 1989;Guarini et al, 1989). This effect cannot be attributed to an ACTH-(1-24) radical scavenging activity, as demonstrated by the competition experiment.…”

Albumin Saturated With Fatty Acids Prevents Decompensation in a Rat Hemorrhagic Shock Trauma Model With Tourniquet and Hypotensive Resuscitation

“…This was unsustainable, however, and DAP would plummet without a change in HR or PP, suggesting a sudden loss of venous return due to sympathetic signaling failure. Sudden drops in sympathetic signaling occur after hemorrhage in rabbits, supporting this hypothesis (8, 28, 29). After 2 to 3 h of occlusion, the remaining animals would start slowly decreasing pressure until death, suggesting the sympathetic signal was present but decreasing or the vasculature was losing the ability to respond.…”