The Adrenal Medulla

Ziegler, W. H.; Labhart, A.

doi:10.1007/978-3-642-70509-0_8

Cited by 3 publications

(1 citation statement)

References 128 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is estimated that 0.1% of patients with diastolic hypertension have a pheo, with an incidence of about two per million in the population and a male/female ratio of 1:1 [3][4][5]. In the past, the variability of clinical manifestations in patients with pheo led us to describe the tumor as "the great mimic" and the symptoms in these patients as due to excess catecholamine secretion.…”

Section: Discussionmentioning

confidence: 99%

Pheochromocytoma, a Rare Cause of Hypertension: Long‐term Follow‐up of 55 Surgically Treated Patients

et al. 1998

View full text Add to dashboard Cite

Pheochromocytoma is a rare tumor that is found in only 0.1% of patients with diastolic hypertension. We analyze the results of our experience in management of pheochromocytomas and long-term results of its surgical treatment. From 1977 to 1996 we operated on 55 patients with a pheochromocytoma: 29 males and 27 females with an average age of 41 years (range 10-63 years). In 44 (80.0%) patients episodic hypertension or paroxysms were observed; 7 (12.7%) patients had permanent hypertension, and 4 (7.3%) had a normal arterial blood pressure (ABP). 131/123I-MIBG scintigraphy (33 patients) and magnetic resonance imaging (12 patients) showed 100% sensitivity and computed tomography (47 patients) 97.9% sensitivity. At operation five (9.1%) tumors were bilateral, five extraadrenal, and five multiple. In four (7.3%) patients an association with familial syndromes (three MEN-IIb, one von Recklinghausen disease) was observed. Five (9.1%) malignant tumors were discovered, and two patients are still alive 30 and 104 months after surgery, one of them with relapse. In 43 (78.2%) patients we preferred a flank incision, and no intraoperative deaths occurred. Mean follow-up was 88 months (6-232 months) with recurrence in only 1 (2.0%) of 50 patients without malignancy. In patients with benign pheochromocytomas the recurrence rate did not seem to be elevated in our series. Nevertheless, because the lifelong follow-up requires only annual 24-hour urinary catecholamine measurement (less than $40 per patient per year) and periodic ABP measurements, it is suggested for all patients who undergo surgery for pheochromocytoma.

show abstract

Section: Discussionmentioning

confidence: 99%