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Cited by 21 publications
(17 citation statements)
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References 31 publications
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“…Adiponectin (Ad) plays a crucial role in hepatic lipid metabolism, which has been shown to activate the AMPK signaling pathway and mediates lipid metabolism in bovine hepatocytes in vitro by promoting lipid oxidation, suppressing lipid synthesis and reducing hepatic lipid accumulation . The activation of AMPK in the regulation of Ad in lipid metabolism has also been confirmed in vivo in the hamster (Guo et al, 2012) SIRT1 is the most studied member of a family of evolutionarily conserved NAD + -dependent histone/protein deacetylases (Ruderman et al, 2010), which has been best known for mediating the increase in longevity (Sinclair and Guarente, 2006;Finkel et al, 2009). SIRT1 has been identified as a novel regulator of hepatocyte lipid metabolism, via SIRT1/LKB1/AMPK signaling (Hou et al, 2008).…”
Section: Discussionmentioning
confidence: 92%
See 1 more Smart Citation
“…Adiponectin (Ad) plays a crucial role in hepatic lipid metabolism, which has been shown to activate the AMPK signaling pathway and mediates lipid metabolism in bovine hepatocytes in vitro by promoting lipid oxidation, suppressing lipid synthesis and reducing hepatic lipid accumulation . The activation of AMPK in the regulation of Ad in lipid metabolism has also been confirmed in vivo in the hamster (Guo et al, 2012) SIRT1 is the most studied member of a family of evolutionarily conserved NAD + -dependent histone/protein deacetylases (Ruderman et al, 2010), which has been best known for mediating the increase in longevity (Sinclair and Guarente, 2006;Finkel et al, 2009). SIRT1 has been identified as a novel regulator of hepatocyte lipid metabolism, via SIRT1/LKB1/AMPK signaling (Hou et al, 2008).…”
Section: Discussionmentioning
confidence: 92%
“…AMPK also regulates mitochondrial biogenesis and function (Jäger et al, 2007) and increases the ability of a cell to generate ATP and diminish oxidative stress (Ruderman and Prentki, 2004). Recently, several studies have clearly confirmed that AMPK regulates the lipid metabolism in hepatocytes and even in an in vivo model Guo et al, 2012;Huang et al, 2013;Imai et al, 2006;Lian et al, 2011;Oh et al, 2011; All experiments were performed in triplicate. Statistical significance was set as * p < 0.05, **p < 0.01, or ***p < 0.001, ns: no significance.…”
Section: Discussionmentioning
confidence: 99%
“…We previously found that cordycepin decreases LDL cholesterol levels in vivo ( 34 ), but its effi cacy is limited due to poor bioavailability . IMM-H007 was synthesized and observed to stimulate the phosphorylation of AMPK and to decrease lipid biosynthesis ( 35 ). AMPK activation by IMM-H007 may partially explain the observed declines in LDL cholesterol and triglycerides in plasma and liver because AMPK activation attenuates cholesterol synthesis, lipogenesis', and triglyceride synthesis ( 36 ).…”
Section: Imm-h007 Promotes Macrophage Rct In Vivomentioning
confidence: 99%
“…IMM-H007 (triacetyl-3-hydroxyphenyladenosine) is a derivative of cordycepin, which is an adenosine analog [9]. IMM-H007 was observed to stimulate the phosphorylation of AMPK and to decrease lipid biosynthesis [10]. It has been observed to increase the circulating HDL level, and the cholesterol efflux capacity of HDL, and it can also enhance in vivo reverse cholesterol transport (RCT) from macrophages to the plasma, liver, and feces.…”
Section: Introductionmentioning
confidence: 99%