The Acute Effect of Aerobic Exercise on Brachial Artery Endothelial Function in Renal Transplant Recipients

Cosío-Lima, Ludmila; Thompson, Paul D.; Reynolds, Katy; Headley, Samuel; Winter, Christa; Manos, Tina M.; Lagasse, Marie A.; Todorovich, John R.; Germain, Michael

doi:10.1111/j.1520-037x.2006.05408.x

Cited by 21 publications

(24 citation statements)

References 18 publications

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“…As the results of this study indicate, when the blood pressure increase is prevented in a controlled limb, FMD in that limb increases in both SED and ET subjects. This response is similar to what is observed in subjects following low- to moderate-intensity aerobic exercise (4, 13, 22), during which systolic blood pressure does not significantly increase. Together, these findings suggest that a circulating, pro-dilatory factor may be present, and its effects are dampened by the increased barostress on the blood vessels which occurs during weight lifting.…”

Section: Resultssupporting

confidence: 87%

Hypertension during Weight Lifting Reduces Flow-Mediated Dilation in Nonathletes

Buchanan

Kadlec

Hoch

et al. 2017

Medicine &Amp; Science in Sports &Amp; Exercise

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Purpose The purpose of this study was to determine if increased intraluminal pressure is the damaging factor which reduces flow mediated dilation (FMD) in young, healthy subjects following resistance exercise to maximal exertion. Hypothesis Attenuating the rise in brachial artery pressure during weight lifting by placing a blood pressure cuff on the upper arm prevents post-exercise impairment of brachial artery FMD in sedentary individuals. Methods Nine sedentary individuals who exercise ≤1 time/week and six exercise-trained individuals who exercise ≥3 times/week performed leg press exercise to maximal exertion on two separate occasions. During one visit a blood pressure cuff, proximal to the site of brachial artery measurement, was inflated to 100 mmHg to protect the distal vasculature from the rise in intraluminal pressure which occurs during resistance exercise. Brachial artery FMD was determined using ultrasonography before and 30 minutes after weight lifting. Results Without the protective cuff, brachial artery FMD in sedentary individuals was reduced after weight lifting (9.0 ± 1.2% pre-lift vs. 6.6 ± 0.8% post-lift; p=0.005) while in exercise-trained individuals FMD was unchanged (7.4 ± 0.7% pre-lift vs. 8.0 ± 0.9% post-lift; p=0.543). With the protective cuff, FMD no longer decreased, but rather increased in sedentary individuals (8.7 ± 1.2% pre-lift vs. 10.5 ± 1.0% post-lift, p=0.025). An increase in FMD was also seen in exercise-trained subjects when the cuff was present (6.6 ±0.7% pre-lift vs. 10.9 ±1.5% post-lift, p<0.001). Conclusion Protecting the brachial artery from exercise-induced hypertension enhances FMD in sedentary and exercise-trained individuals. These results indicate that increased intraluminal pressure in the artery contributes to the reduced FMD following heavy resistance exercise in sedentary individuals.

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Section: Resultssupporting

confidence: 87%

Hypertension during Weight Lifting Reduces Flow-Mediated Dilation in Nonathletes

Buchanan

Kadlec

Hoch

et al. 2017

Medicine &Amp; Science in Sports &Amp; Exercise

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“…Many studies showed that aerobic training is a strong inducer of NO production, as the exercise increases blood flow and the shear stress acts as an intense stimulus on the endothelium. 57,58 As stated earlier, as the levels of insulin were not different between trained and untrained diabetic rats in our experiments, it is suggested that there was no interference of endogenous insulin concentrations on NO production in these animals. In summary, aerobic training during eight weeks had beneficial effects over the metabolic profile of DM rats, with better glycemic control, weight increase, associated to a reduction of albuminuria and TBARS, amelioration of the kidney's function and NO production, and absence of renal lesions.…”

Section: Discussionsupporting

confidence: 74%

Effects of training and nitric oxide on diabetic nephropathy progression in type I diabetic rats

Rodrigues¹,

Bergamaschi²,

Araújo³

et al. 2011

Exp Biol Med (Maywood)

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The aim of the paper is to assess nitric oxide (NO) production during aerobic training and its role on the progression of diabetic nephropathy in rats. Induction of diabetes mellitus (DM) was achieved in adult male Wistar rats with streptozotocin. Half of the animals underwent training on a treadmill and the others (sedentary) stayed on a turned-off treadmill for the same period according to the following groups: sedentary control (CTL + SE); training control (CTL + EX); sedentary diabetic (DM + SE); and training diabetic (DM + EX) (n = 9 for all groups). The training on treadmill was carried out at a work rate of 16 m/min, 60 min/d, 5 d/week for eight weeks. Before and after the exercises, rats were placed in individual metabolic cages with standard chow and water ad libitum, for 24-h urine collection, followed by three hours' fasting blood sample withdrawal from the retro-orbital plexus, under anesthesia. Diabetic animals showed reduction of body weight, creatinine and urea depurations and NO excretion, increased blood glucose concentrations, albuminuria and thiobarbituric acid reactive substance (TBARS) excretion, when compared with the respective controls. All these alterations induced by DM were attenuated in the DM + EX versus DM + SE group. Analysis of insulin concentrations at the end of the protocol showed no significant change between the DM + SE and DM + EX groups. In conclusion, our data show that a routine physical exercise resulted in a better control of glycemia with an increased NO bioavailability and oxidative stress control, associated with an amelioration of renal function. We suggest aerobic training and the control of oxidative and nitrosative stress as useful non-pharmacological tools to delay the progression of diabetic nephropathy.

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“…In contrast to these reports, sustained increase of FMD after acute exercise was observed in postmenopausal women [25]. Regarding healthy controls, Cosio-Lima et al showed acute vasodilatory response after 30-minute walk, comparing FMD between healthy controls and kidney transplant recipients [26]. In a recent study of Llewellyn et al, some interesting findings were reported [29].…”

Section: Discussionmentioning

confidence: 99%

“…Despite the abundance of evidence regarding the chronic effect of exercise on FMD, the impact of acute exercise is still inconclusive. Several researchers have reported reduction of FMD immediately after exercise [22-24], while others have reported improvement [25,26]. Utilization of acute exercise model is advantageous for prescription of appropriate exercise protocol for patients, experimental control of confounding variables, and investigation of mechanisms of acute exercise response [27].…”

Section: Introductionmentioning

confidence: 99%

Impact of acute exercise on brachial artery flow-mediated dilatation in young healthy people

Hwang

Kim

Choi

et al. 2012

Cardiovasc Ultrasound

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BackgroundAlthough chronic effects of exercise on endothelial function are established, the impact of acute exercise on flow-mediated dilatation (FMD) of brachial artery has not been elucidated yet.MethodsEighty-six young healthy volunteers were prospectively enrolled from January 2011 to December 2011. The subjects completed FMD tests at rest and immediately after treadmill exercise test. Primary outcome was the impact of acute exercise on FMD, measured by the difference of FMD before and after exercise. Secondary outcomes were the relationship of gender and exercise habit with FMD.ResultsSeventy-four subjects who met the eligibility criteria were included for analysis. Thirty-five (47.3%) were male, and the mean age was 22.7±2.7 years. FMD was reduced after exercise (8.98±4.69 to 7.51±4.03%; P=0.017) and the reduction was found in female group (10.36±5.26 to 7.62±3.71%; P=0.002) but not in male group. Post-exercise FMD was significantly impaired in subjects who did not exercise regularly (6.92±3.13% versus 8.95±5.33%; P=0.003). The decrease of FMD after exercise was greater in female group (−2.75±5.28% versus 0.27±3.24%; P=0.003) and was associated with exercise habit (β=2.532; P=0.027).ConclusionsIn healthy young subjects, FMD was reduced after a bout of acute exercise. The impact of acute exercise showed significant differences according to gender and exercise habit. FMD impairment after acute exercise was observed in females and subjects without regular exercise.

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The Acute Effect of Aerobic Exercise on Brachial Artery Endothelial Function in Renal Transplant Recipients

Cited by 21 publications

References 18 publications

Hypertension during Weight Lifting Reduces Flow-Mediated Dilation in Nonathletes

Hypertension during Weight Lifting Reduces Flow-Mediated Dilation in Nonathletes

Effects of training and nitric oxide on diabetic nephropathy progression in type I diabetic rats

Impact of acute exercise on brachial artery flow-mediated dilatation in young healthy people

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