The Actual Six Therapeutic Modalities

Bocci, Velio

doi:10.1007/978-90-481-9234-2_6

Cited by 3 publications

(3 citation statements)

References 99 publications

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“…During major autohaemotherapy (MAH), 100 cc of blood was preferentially withdrawn from an antecubital vein and mixed gently with 100 cc O3 gas at a 1:1 ratio of oxygen-ozone to blood volume for at least 5 min as previously described (33)(34)(35)(36)(37). Briefly, 100 mL of blood was withdrawn from each patient into special ozone bottles under vacuum containing 12 cc 3.13% sodium citrate.…”

Section: Application Of Ozone Therapymentioning

confidence: 99%

Ozone therapy as a novel complementary therapeutic approach in refractory idiopathic granulomatous mastitis

et al. 2023

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BackgroundAutoimmunity may play a major role in the pathogenesis of idiopathic granulomatous mastitis (IGM). The therapeutic potential of ozone therapy has recently been shown in rheumatological diseases, and this study aimed to assess the clinical efficacy of ozone therapy (OT) in refractory IGM.MethodsPatients with biopsy-verified IGM and incomplete response after steroid therapy (n = 47) between 2018 and 2021 were enrolled. Of these, 23 cases in cohort A had standard treatment with further steroid therapy (ST), and 24 were treated with systemic OT via autohemotherapy (AHT) in addition to steroid therapy (cohort B).ResultsThe median age was 33 years (range, 24–45). Patients in cohort B had a higher complete response rate after completion of a four-month ozone therapy than those in the ST-group (OT-group, 37.5% vs. ST-group, 0%; p = 0.002). At a median follow-up of 12 months (range, 12–35), the patients treated with OT had a lower one-year recurrence in the affected breast than cases in cohort A treated with ST (OT-group, 21% vs. ST-group, 70%; p = 0.001). No significant side effects were observed in patients in cohort B related to AHT. Furthermore, OT significantly decreased the total steroid treatment duration (median week of steroid use; 26 weeks in cohort A vs. 12 weeks in cohort B; p = 0.001).ConclusionSystemic OT increases the complete response rate and decreases the duration of steroid treatment in patients with refractory IGM. Therefore, ozone therapy is an effective, well-tolerated, and safe novel complementary therapeutic modality.

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Section: Application Of Ozone Therapymentioning

confidence: 99%

Ozone therapy as a novel complementary therapeutic approach in refractory idiopathic granulomatous mastitis

et al. 2023

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“…: (1) the major and minor ozonated autohemotherapy; (2) the extracorporeal circulation of blood against oxygen-ozone; (3) the quasi-total body exposure to oxygen-ozone; (4) the intraca-vitary, subcutaneous, intramuscular administration, and (5) the ozone insufflation via rectum is the most erratic administration route. These routes with their relative mechanisms of action have been already extensively analyzed [62,63]. Moreover, a few caveats need to be discussed: (i) in Europe at least 40% of patients refuse the administration of ozone via rectum; (ii) part of the ozone dose may be unwillingly eliminated immediately after the gas introduction; (iii) the fecal content and the abundant mucoproteins certainly neutralize part of the ozone dose, and (iv) in all cases ozone, unlike oxygen, is not absorbed by the rectal mucosa.…”

Section: Is There Experimental and Clinical Evidence That Ozonetherap...mentioning

confidence: 99%

Diabetes and chronic oxidative stress. A perspective based on the possible usefulness of ozone therapy

Bocci

Zanardi

Huijberts

et al. 2011

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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“…Interestingly, ozonated saline is an efficient irrigation solution for minimizing abscess development compared to regular saline solution and saline–cephalothin irrigation in treating fecal peritonitis in rats [ 19 ]. It was noted that rectal insufflation, as opposed to intravenous and intramuscular methods, was the least unpleasant, safest, and most practical way for administering ozone to 72 non-diabetic individuals with vascular occlusion due to atherosclerosis [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Ozone Therapy in Medicine and Dentistry: A Review of the Literature

2023

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Ozone has been successfully used in medicine for over 100 years due to its microbiological qualities. Its powerful oxidation impact, which results in the production of free radicals, and its ability to cause the direct death of nearly all microorganisms is the basis for its bactericide, virucide, and fungicide properties. Ozone also has a medicinal impact that speeds up blood flow and aids wound healing. Ozone may be applied as a gas or dissolved in water for medical purposes. Despite the benefits of using ozone therapeutically, concerns about its use in dentistry still exist. We aimed to provide a summary of the current uses of ozone in medicine and dentistry. An electronic search was performed for all English scientific papers published between 2012 and 2023 using PubMed, Cochrane, and Google Scholar search engines. Ozone, clinical applications, medicine, and dentistry were the search terms used. Seventy full-text articles describing the use of ozone therapy in medicine and dentistry were included in the present review. Ozone has shown several beneficial effects in the medical field. However, despite the encouraging in vitro evidence, the clinical use of ozone in dentistry has not yet been demonstrated as highly effective.

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The Actual Six Therapeutic Modalities

Cited by 3 publications

References 99 publications

Ozone therapy as a novel complementary therapeutic approach in refractory idiopathic granulomatous mastitis

Ozone therapy as a novel complementary therapeutic approach in refractory idiopathic granulomatous mastitis

Diabetes and chronic oxidative stress. A perspective based on the possible usefulness of ozone therapy

Ozone Therapy in Medicine and Dentistry: A Review of the Literature

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