The Activation of the RIG-I/MDA5 Signaling Pathway upon Influenza D Virus Infection Impairs the Pulmonary Proinflammatory Response Triggered by Mycoplasma bovis Superinfection

Gaudino, Maria; Lion, Adrien; Sagné, Eveline; Nagamine, Brandy; Oliva, Joan; Terrier, B.; Errazuriz-Cerda, Elisabeth; Scribe, Anaëlle; Sikht, Fatima-Zohra; Simon, Elisa; Foret‐Lucas, Charlotte; Gausserès, Blandine; Lion, Julie; Moreno, Ana; Dordet‐Frisoni, Emilie; Baranowski, Éric; Volmer, Romain; Ducatez, Mariette; Meyer, Gilles

doi:10.1128/jvi.01423-22

Cited by 7 publications

(9 citation statements)

References 72 publications

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“… 2021 ; Gaudino et al. 2023 ). In France, Mycoplasma bovis is the most frequently isolated etiologic agent in these BRDC outbreaks, spreading early and widely throughout the affected units (60–100% isolation rate and seroconversion) (Arcangioli et al.…”

Section: Discussionmentioning

confidence: 99%

“… 2020 ; Gaudino et al. 2023 ), especially for young feedlot calves, ranging from 30% in Belgium (van Leenen et al. 2020 ), to 49% in Switzerland, and up to 90% in the U.S.A (Hilton 2014 ).…”

Section: Discussionmentioning

confidence: 99%

“…A plethora of examples in ruminants and swine illustrate the framework for coinfection between pathogens (Gaudino et al. 2023 ), especially in crowded conditions and breeding programs that are overly focused on enhancing traits related to production instead of robustness and resilience. In this context, multiple viral agents can contribute to the development of BRDC (Holman et al.…”

Section: Discussionmentioning

confidence: 99%

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The forecasting power of the mucin-microbiome interplay in livestock respiratory diseases

Mach

2024

Veterinary Quarterly

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Complex respiratory diseases are a significant challenge for the livestock industry worldwide. These diseases considerably impact animal health and welfare and cause severe economic losses. One of the first lines of pathogen defense combines the respiratory tract mucus, a highly viscous material primarily composed of mucins, and a thriving multi-kingdom microbial ecosystem. The microbiome-mucin interplay protects from unwanted substances and organisms, but its dysfunction may enable pathogenic infections and the onset of respiratory disease. Emerging evidence also shows that noncoding regulatory RNAs might modulate the structure and function of the microbiome-mucin relationship. This opinion paper unearths the current understanding of the triangular relationship between mucins, the microbiome, and noncoding RNAs in the context of respiratory infections in animals of veterinary interest. There is a need to look at these molecular underpinnings that dictate distinct health and disease outcomes to implement effective prevention, surveillance, and timely intervention strategies tailored to the different epidemiological contexts.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The forecasting power of the mucin-microbiome interplay in livestock respiratory diseases

Mach

2024

Veterinary Quarterly

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“…Despite that clinical signs and susceptibility to secondary bacterial infection with Mannheimia haemolytica in calves are not increased by a primary infection with IDV [ 26 ], calves co-infected with IDV and Mycoplasma bovis suffer from a more severe respiratory disease than those infected with either at the same condition [ 31 ], implying that IDV may facilitate certain coinfections within the BRD complex. Further research found that IDV was likely to trigger immune pathways that inhibited the innate immune response against the bacteria, which resulted in an increased susceptibility to the secondary bacterial infection in cattle [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Influenza D virus infection in China, 2022–2023

Yu,

Wen,

et al. 2024

Emerging Microbes & Infections

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Influenza D virus (IDV) plays an important role in the bovine respiratory disease (BRD) complex. Its potential for the zoonotic transmission is of particular concern. In China, IDV has previously been identified in agricultural animals by molecular surveys with no live virus isolates reported. In this study, live IDVs were successfully isolated from cattle in China, which prompted us to further investigate the national prevalence, antigenic property, and infection biology of the virus. IDV RNA was detected in 11.1% (51/460) of cattle throughout the country in 2022–2023. Moreover, we conducted the first IDV serosurveillance in China, revealing a high seroprevalence (91.4%, 393/430) of IDV in cattle during the 2022–2023 winter season. Notably, all the 16 provinces from which cattle originated possessed seropositive animals, and 3 of them displayed the 100% IDV-seropositivity rate. In contrast, a very low seroprevalence of IDV was observed in pigs (3%, 3/100) and goats (1%, 1/100) during the same period of investigation. Furthermore, besides D/Yama2019 lineage-like IDVs, we discovered the D/660 lineage-like IDV in Chinese cattle, which has not been detected to date in Asia. Finally, the Chinese IDVs replicated robustly in diverse cell lines but less efficiently in the swine cell line. Considering the nationwide distribution, high seroprevalence, and appreciably genetic diversity, further studies are required to fully evaluate the risk of Chinese IDVs for both animal and human health in China, which can be evidently facilitated by IDV isolates reported in this study.

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“…In addition, IDV co-infection increased the replication of M. bovis . The interaction between IDV and M. bovis was additionally studied in ex vivo models using precision-cut lung slices by Gaudino et al [ 18 ]. The results suggested that a primary IDV infection promoted M. bovis superinfection by increasing bacterial replication and by causing damage to lung pneumocytes.…”

Section: Introductionmentioning

confidence: 99%

Proteomic and Lipidomic Profiling of Calves Experimentally Co-Infected with Influenza D Virus and Mycoplasma bovis: Insights into the Host–Pathogen Interactions

Alvarez,

Ducatez,

Guo

et al. 2024

Viruses

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The role of Influenza D virus (IDV) in bovine respiratory disease remains unclear. An in vivo experiment resulted in increased clinical signs, lesions, and pathogen replication in calves co-infected with IDV and Mycoplasma bovis (M. bovis), compared to single-infected calves. The present study aimed to elucidate the host–pathogen interactions and profile the kinetics of lipid mediators in the airways of these calves. Bronchoalveolar lavage (BAL) samples collected at 2 days post-infection (dpi) were used for proteomic analyses by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Additionally, lipidomic analyses were performed by LC-MS/MS on BAL samples collected at 2, 7 and 14 dpi. Whereas M. bovis induced the expression of proteins involved in fibrin formation, IDV co-infection counteracted this coagulation mechanism and downregulated other acute-phase response proteins, such as complement component 4 (C4) and plasminogen (PLG). The reduced inflammatory response against M. bovis likely resulted in increased M. bovis replication and delayed M. bovis clearance, which led to a significantly increased abundance of oxylipids in co-infected calves. The identified induced oxylipids mainly derived from arachidonic acid; were likely oxidized by COX-1, COX-2, and LOX-5; and peaked at 7 dpi. This paper presents the first characterization of BAL proteome and lipid mediator kinetics in response to IDV and M. bovis infection in cattle and raises hypotheses regarding how IDV acts as a co-pathogen in bovine respiratory disease.

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The Activation of the RIG-I/MDA5 Signaling Pathway upon Influenza D Virus Infection Impairs the Pulmonary Proinflammatory Response Triggered by Mycoplasma bovis Superinfection

Cited by 7 publications

References 72 publications

The forecasting power of the mucin-microbiome interplay in livestock respiratory diseases

The forecasting power of the mucin-microbiome interplay in livestock respiratory diseases

Influenza D virus infection in China, 2022–2023

Proteomic and Lipidomic Profiling of Calves Experimentally Co-Infected with Influenza D Virus and Mycoplasma bovis: Insights into the Host–Pathogen Interactions

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