The activation of NF-κB and MAPKs signaling pathways of RAW264.7 murine macrophages and natural killer cells by fucoidan from Nizamuddinia zanardinii

Tabarsa, Mehdi; Dabaghian, Elham Hashem; You, SangGuan; Yelithao, Khamphone; Cao, Rong-An; Rezaei, Masoud; Alboofetileh, Mehdi; Bita, Seraj

doi:10.1016/j.ijbiomac.2020.01.125

Cited by 44 publications

(29 citation statements)

References 41 publications

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“…Recently, Tabarsa et al [ 79 ] evaluated the effect of Nizamuddinia zanardinii fucoidan on the RAW264.7 murine macrophage cell line and NK-92 cells. One of the fractions obtained from the brown seaweed showed well-defined immune-enhancing activity.…”

Section: Immunomodulatory Effect Of Fucoidanmentioning

confidence: 99%

“…One of the fractions obtained from the brown seaweed showed well-defined immune-enhancing activity. This polysaccharide induced increased secretion of NO, TNF-α, IL-1β, and IL-6 and activation of NK cells, NF-κB, and MAPKs signaling pathways with subsequent release of TNF-α and INF-γ [ 79 ]. Fucoidan derived from A. nodosum and F. vesiculosus also induced NO synthesis and cytokine production via activation of NF-κB and AP-1 signaling pathways in RAW264.7 cells [ 80 ].…”

Section: Immunomodulatory Effect Of Fucoidanmentioning

confidence: 99%

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Immunomodulatory and Anti-Inflammatory Effects of Fucoidan: A Review

et al. 2020

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Inflammation is the initial response of the immune system to potentially harmful stimuli (e.g., injury, stress, and infections). The process involves activation of macrophages and neutrophils, which produce mediators, such as nitric oxide (NO), prostaglandin E2 (PGE2), pro-inflammatory and anti-inflammatory cytokines. The pro-inflammatory cytokines interleukin-1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) are considered as biomarkers of inflammation. Even though it occurs as a physiological defense mechanism, its involvement in the pathogenesis of various diseases is reported. Rheumatoid arthritis, inflammatory bowel disease, Alzheimer’s disease, and cardiovascular diseases are only a part of the diseases, in which pathogenesis the chronic inflammation is involved. Fucoidans are complex polysaccharides from brown seaweeds and some marine invertebrates, composed mainly of L-fucose and sulfate ester groups and minor amounts of neutral monosaccharides and uronic acids. Algae-derived fucoidans are studied intensively during the last years regarding their multiple biological activities and possible therapeutic potential. However, the source, species, molecular weight, composition, and structure of the polysaccharides, as well as the route of administration of fucoidans, could be crucial for their effects. Fucoidan is reported to act on different stages of the inflammatory process: (i) blocking of lymphocyte adhesion and invasion, (ii) inhibition of multiple enzymes, and (iii) induction of apoptosis. In this review, we focused on the immunemodulating and anti-inflammatory effects of fucoidans derived from macroalgae and the models used for their evaluation. Additional insights on the molecular structure of the compound are included.

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Section: Immunomodulatory Effect Of Fucoidanmentioning

confidence: 99%

Section: Immunomodulatory Effect Of Fucoidanmentioning

confidence: 99%

Immunomodulatory and Anti-Inflammatory Effects of Fucoidan: A Review

et al. 2020

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“…SGs from brown seaweed Cystoseria indica induced the release of NO from RAW 264.7 by activating the Toll-like 4 receptor (TLR4)/NF-κB and MAPKs signaling pathways (Bahramzadeh et al, 2019). Another sulfated polysaccharide from seaweed, Nizamuddinia zanardinii, similarly activated RAW 264.7 to secrete NO, TNF-α, and other cytokines (Tabarsa et al, 2020). Additional in vitro studies further reported that galactans also activate Mfs to M1-like phenotype.…”

Section: Resultsmentioning

confidence: 93%

Sulfated agarans from red seaweed Gracilaria cornea induce macrophages polarization to an antitumor M1 phenotype

Anb

et al. 2021

Preprint

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Marine seaweeds are a rich source of sulfated polysaccharides (SPs) with several biological activities, including antitumor effect. Some polysaccharides are also described to activate macrophages (MΦs) to an antitumor M1-like phenotype. Here, we evaluated the capacity of SPs extracts obtained from three seaweed species, Gracilaria cornea (Gc-E), Gracilaria birdiae (Gb-E), and Solieria filiformis (Sf-E), to activate the MΦs antitumor M1 phenotype. The nitric oxide production, MHCII, and CD86 M1 markers were evaluated to screening the bioactive SPs profile on murine MΦs (RAW 264.7 cells). The direct SPs antiproliferative effect was tested on melanoma B16-F10 cells. In another experimental setting, B16-F10 cells were incubated with a conditioned medium obtained from MΦs exposed to SPs. The three SPs tested induced NO release. Sf-E directly inhibited B16-F10 cells proliferation compared with the saline group, but Gc-E and Gb-E failed to inhibit cell proliferation. Notably, a conditioned medium (CM) of MΦs incubated with Gc-E and Sf-E, but not of Gb-E, inhibited the proliferation of B16-F10 cells. Gc-E also induced TNF-α release and increase of M1 markers such as iNOS, MHCII, and CD86. Therefore, Gc-E activates a macrophage M1 phenotype, which in turn releases a factor that inhibits B16-F10 proliferation.

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“…For example, fucoidan derived from the algae Nizamuddinia zanardinii exhibits well-defined immune-enhancing activity on murine macrophage cell and human natural killer cells. In this in vitro model, fucoidan contributes to the secretion of cytokines, including nitrous oxide, TNF-α, IL-1β, IL-6, NF-κB and stimulates the MAPK signaling pathways [ 74 ].…”

Section: Biomaterials From Marine Organismsmentioning

confidence: 99%

Biomaterials from the sea: Future building blocks for biomedical applications

Wan

Qin

Chen

et al. 2021

Bioactive Materials

100

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Marine resources have tremendous potential for developing high-value biomaterials. The last decade has seen an increasing number of biomaterials that originate from marine organisms. This field is rapidly evolving. Marine biomaterials experience several periods of discovery and development ranging from coralline bone graft to polysaccharide-based biomaterials. The latter are represented by chitin and chitosan, marine-derived collagen, and composites of different organisms of marine origin. The diversity of marine natural products, their properties and applications are discussed thoroughly in the present review. These materials are easily available and possess excellent biocompatibility, biodegradability and potent bioactive characteristics. Important applications of marine biomaterials include medical applications, antimicrobial agents, drug delivery agents, anticoagulants, rehabilitation of diseases such as cardiovascular diseases, bone diseases and diabetes, as well as comestible, cosmetic and industrial applications.

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The activation of NF-κB and MAPKs signaling pathways of RAW264.7 murine macrophages and natural killer cells by fucoidan from Nizamuddinia zanardinii

Cited by 44 publications

References 41 publications

Immunomodulatory and Anti-Inflammatory Effects of Fucoidan: A Review

Immunomodulatory and Anti-Inflammatory Effects of Fucoidan: A Review

Sulfated agarans from red seaweed Gracilaria cornea induce macrophages polarization to an antitumor M1 phenotype

Biomaterials from the sea: Future building blocks for biomedical applications

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