The Actinic (Solar) Keratosis

Fu, Weijie; Cockerell, Clay J.

doi:10.1001/archderm.139.1.66

Cited by 130 publications

(37 citation statements)

References 19 publications

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“…In albinos however these cancers are known to present earlier [4,7,9,17]. Ademiluyi and Ijaduola [18] reported that black patients presented between the 3rd and 4th decades, whereas the albinos presented a decade earlier.…”

Section: Discussionmentioning

confidence: 99%

Skin cancers among Albinos at a University teaching hospital in Northwestern Tanzania: a retrospective review of 64 cases

et al. 2012

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BackgroundSkin cancers are a major risk associated with albinism and are thought to be a major cause of death in African albinos. The challenges associated with the care of these patients are numerous and need to be addressed. The aim of this study was to outline the pattern and treatment outcome of skin cancers among albinos treated at our centre and to highlight challenges associated with the care of these patients and proffer solutions for improved outcome.MethodsThis was a retrospective study of all albinos with a histopathological diagnosis of skin cancer seen at Bugando Medical Centre from March 2001 to February 2010. Data collected were analyzed using descriptive statistics.ResultsA total of 64 patients were studied. The male to female ratio was 1.5:1. The median age of patients was 30 years. The median duration of illness at presentation was 24 months. The commonest reason for late presentation was financial problem. Head and the neck was the most frequent site afflicted in 46(71.8%) patients. Squamous cell carcinoma was the most common histopathological type in 75% of cases. Surgical operation was the commonest modality of treatment in 60 (93.8%) patients. Radiotherapy was given in 24(37.5%) patients. Twenty-seven (42.2%) of the patients did not complete their treatment due to lack of funds. Local recurrence following surgical treatment was recorded in 6 (30.0%) patients. Only thirty-seven (61.7%) patients were available for follow-up at 6–12 months and the remaining patients were lost to follow-up.ConclusionsSkin cancers are the most common cancers among albinos in our environment. Albinism and exposure to ultraviolet light appears to be the most important risk factor in the development of these cancers. Late presentation and failure to complete treatment due to financial difficulties and lack of radiotherapy services at our centre are major challenges in the care of these patients. Early institution of preventive measures, early presentation and treatment, and follow-up should be encouraged in this population for better outcome.

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Section: Discussionmentioning

confidence: 99%

Skin cancers among Albinos at a University teaching hospital in Northwestern Tanzania: a retrospective review of 64 cases

et al. 2012

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“…2 Actinic Keratoses (AK) AKs are precancerous lesions found most frequently on the sun-exposed areas of the skin such as the face, lower lip, bald scalp, neck, arms, and hands. [29][30] AKs make up a major part of a dermatologistÕs practice, 31 and a small proportion of them progress to invasive cancer (estimated range from 0.25% to 20% per year). [29][30][31][32] Imiquimod should be applied 2 times a week for 16 weeks to the entire treatment area.…”

Section: Approved Clinical Usesmentioning

confidence: 99%

Viral and Nonviral Uses of Imiquimod: A Review

2004

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“…Males develop actinic keratoses more frequently than females. [5] They usually occur on sun exposed areas. Actinic keratoses is a clinical manifestation of UV radiation (most commonly UV-B radiation) induced neoplastic transformation of keratinocytes.…”

Section: Discussionmentioning

confidence: 99%

“…Actinic keratoses is a clinical manifestation of UV radiation (most commonly UV-B radiation) induced neoplastic transformation of keratinocytes. [5,6] The UV-B radiation causes thymidine dimer formation in DNA and RNA, resulting in mutations causing neoplastic changes in keratinocytes. The two important sites of mutations taking place in actinic keratoses formation are in telomerase and the tumor suppressor gene p53, located on chromosome 17p132.…”

Section: Discussionmentioning

confidence: 99%

Malignant transformation of actinic keratoses to squamous cell carcinoma in an albino

2009

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A 25-year-old male, who was a known case of oculocutaneous albinism presented to us with right inguinal swellings of six months' duration. He gave a preceding history of a similar lump in the right thigh, which was excised at the Chennai Government Hospital. He was diagnosed to have oculocutaneous albinism with actinic keratoses, with multiple squamous cell carcinomas (with metastatic deposits in the right inguinal region) and cutaneous horns. The case is reported to highlight preventive aspects in the management of albinos.

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The Actinic (Solar) Keratosis

Cited by 130 publications

References 19 publications

Skin cancers among Albinos at a University teaching hospital in Northwestern Tanzania: a retrospective review of 64 cases

Skin cancers among Albinos at a University teaching hospital in Northwestern Tanzania: a retrospective review of 64 cases

Viral and Nonviral Uses of Imiquimod: A Review

Malignant transformation of actinic keratoses to squamous cell carcinoma in an albino

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