The accelerated repopulation of a murine fibrosarcoma, FSa-ii, during the fractionated irradiation and the linear-quadratic model

Abe, Yoshinao; Urano, Muneyasu; Kenton, Lydia A.; Kahn, Julia; Willet, Christopher G.

doi:10.1016/0360-3016(91)90329-3

Cited by 20 publications

(4 citation statements)

References 23 publications

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“…Therefore, significantly increased FSaII cell killing at the relatively small radiation doses used in the clonogenic assay experiments was only observed when mice were exposed to RSR13 and carbogen rather than carbogen alone or RSR13 and air. ( 5 ) The a / p ratio of 10.1 Gy was consistent with a reduction in the size of the hypoxic fraction of FSaII tumors in mice exposed to RSR13 and carbogen compared to the previously reported a@ ratio of 29.5 Gy, as determined by combined lung colony and 50% tumor cell dose dilution assay data, in mice exposed to air [29]. (6) The reduced FSaII cell survival due to RSR13 in combination with radiation in vivo was probably not due to toxicity because RSR13 alone did not affect FSaII tumor growth or cell survival in vivo, RSRl3 alone did not affect FSaII cell proliferation in vitro, and RSR13 did not enhance the effects of radiation on FSaII cell proliferation in vitro, where O2 transport physiology does not apply.…”

Section: Discussionsupporting

confidence: 84%

Increased radiation response of FSaII fibrosarcomas in C3H mice following administration of an allosteric effector of hemoglobin-oxygen affinity

Khandelwal

Lin

Hall

et al. 1996

Radiat. Oncol. Investig.

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Section: Discussionsupporting

confidence: 84%

Increased radiation response of FSaII fibrosarcomas in C3H mice following administration of an allosteric effector of hemoglobin-oxygen affinity

Khandelwal

Lin

Hall

et al. 1996

Radiat. Oncol. Investig.

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“…There are many publications on experimental tumors that have shown rates of repopulation after radiotherapy equal to or often faster than rates of cell repopulation in tumors without exposure to radiotherapy [11][12][13].…”

Section: Discussionmentioning

confidence: 99%

Growth rate of newly developed metastatic brain tumors after thoracotomy in patients with non-small cell lung cancer

Yoo¹,

Jung²,

Nam³

et al. 2011

Lung Cancer

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“…There are many publications on experimental tumours that have shown rates of repopulation after radiotherapy that are equal to or often faster than the rates of cell repopulation in tumours without radiotherapy (Hermens and Barendsen, 1967;Suit and Urano, 1969;Abe et al, 1991;Begg et al, 1991;Milas et al, 1994). Intervals between chemotherapy doses are needed to allow repopulation of normal tissues.…”

Section: Repopulation and Tumour Doubling Timementioning

confidence: 99%

Accelerated regrowth of non-small-cell lung tumours after induction chemotherapy

2003

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Induction chemotherapy of non-small-cell lung cancer (NSCLC) stage III with gemcitabine and cisplatin for downstaging of the tumour with the aim for further treatment with ionising radiation is one of the treatments for lung cancer patients. The purpose of this study was to investigate the influence of the waiting time for radiotherapy, that is, the interval between induction chemotherapy and radiotherapy, on the rate of tumour growth for patients with NSCLC. Interval times between the end of induction chemotherapy and date of diagnostic CT, planning CT and first day of radiotherapy were determined for 23 patients with NSCLC. Increase in gross tumour volume was measured for 18 patients by measuring the dimensions of the primary tumour and lymph node metastases on the diagnostic CT after induction chemotherapy and on the CT used for radiotherapy planning. For each patient, the volume doubling time was calculated from the time interval between the two CTs and ratio of the gross volumes on planning CT and diagnostic CT. The mean time interval between end of chemotherapy and day of diagnostic CT was 16 days, and till first day of radiotherapy 80.3 (range 29 -141) days. In all, 41% of potentially curable patients became incurable in the waiting period. The ratio of gross tumour volumes of the two CTs ranged from 1.1 to 81.8 and the tumour doubling times ranged from 8.3 to 171 days, with a mean value of 46 days and median value of 29 days. This is far less than the mean doubling time of NSCLC in untreated patients found in the literature. This study shows that in the time interval between the end of induction chemotherapy and the start of radiotherapy rapid tumour progression occurs as a result of accelerated tumour cell proliferation: mean tumour doubling times are much shorter than those in not treated tumours. As a consequence, the gain obtained with induction chemotherapy with regard to volume reduction was lost in the waiting time for radiotherapy. We recommend diminishing the time interval between chemo-and radiotherapy to as short as possible.

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The accelerated repopulation of a murine fibrosarcoma, FSa-ii, during the fractionated irradiation and the linear-quadratic model

Cited by 20 publications

References 23 publications

Increased radiation response of FSaII fibrosarcomas in C3H mice following administration of an allosteric effector of hemoglobin-oxygen affinity

Increased radiation response of FSaII fibrosarcomas in C3H mice following administration of an allosteric effector of hemoglobin-oxygen affinity

Growth rate of newly developed metastatic brain tumors after thoracotomy in patients with non-small cell lung cancer

Accelerated regrowth of non-small-cell lung tumours after induction chemotherapy

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