Abstract:Introduction
Inflammation of the gut lining constitute the basis for IBD pathogenesis, a disease with multifactorial etiology. In addition, there is suggestive evidence that the interaction of CD147, β1 integrin and Syndecan‐1 (Sdc‐1) could control the inflammation process and impact healing.
Aim
The aim of this work is to look at the pathogenesis of IBD in Sdc‐1 null mice as compared to control (BALB/C). Our hypothesis is that in the absence of Sdc‐1 a more severe inflammation will be observed.
Method
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