Junko Zenkoh, Ariungerel Gerelchuluun, Yuzi Wang, Yoshihiro Miwa, Tadao Ohno, Koji Tsuboi
Abstract:Background: Localized radiotherapy is considered to act as an adjuvant for systemic anti-tumor immunity. We examined whether in situ-irradiated peripheral tumor cells can evoke an abscopal effect in the brain inhibiting malignant tumor growth. Methods: Syngeneic albino C57BL/6 mice were inoculated with mouse glioma cells (GL261) transfected with the Kusabira Orange fluorescent gene (GL261-mKO) for monitoring the tumor growth with in vivo imaging system. GL261-mKO cells were subcutaneously implanted in the thig…
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