Caitlin W. Brown, John J. Amante, Hira Lal Goel, Arthur M. Mercurio
Abstract:Lipid peroxidation in the plasma membrane can cause ferroptosis, a form of regulated necrosis. Brown et al. show that matrix detachment can induce ferroptosis, and the α6β4 integrin impedes that process by suppressing expression of the proferroptotic enzyme ACSL4.
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