Journal of Cell Biology volume 216, issue 12, P4287-4297 2017 DOI: 10.1083/jcb.201701136 View full text
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Caitlin W. Brown, John J. Amante, Hira Lal Goel, Arthur M. Mercurio

Abstract: Lipid peroxidation in the plasma membrane can cause ferroptosis, a form of regulated necrosis. Brown et al. show that matrix detachment can induce ferroptosis, and the α6β4 integrin impedes that process by suppressing expression of the proferroptotic enzyme ACSL4.