Thallium-201 for oncological imaging in children

Nadel, Helen

doi:10.1016/s0001-2998(05)80105-9

Cited by 39 publications

(8 citation statements)

References 34 publications

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“…On the other hand, experiments with the Ca 2+ loaded RHM showed a decrease in state 3U DNP res piration, the RCR DNP , and ΔΨ mito together with the increased swelling in medium containing TlNO 3 as well as KNO 3 and NH 4 NO 3 [16] or NaNO 3 (Figs. 4,b,5,6). As in the case of the Ca 2+ loaded RLM [15], these effects were attenuated considerably in the presence of the MPTP inhibitors (ADP, CsA) ( Figs.…”

Section: Resultsmentioning

confidence: 68%

Influence of Tl(+) on the Ca(2+) and Na(+) movement across rat neonatal cardiomyocytes and rat heart mitochondria membranes

et al. 2020

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thallium is known to produce one of the most complex and serious patterns of toxicity, involving a wide range of human organs and tissues. the toxic impact on biologic organisms is linked especially to the ability of tl + to disturb calcium homeostasis and to permeate easily the inner mitochondrial membrane (IMM). the aim of this work was to study the effects of Tl + on intracellular Ca 2+ dynamics in rat neonatal cardiomyocytes as well as on sodium penetrability of the IMM and tl + -induced mitochondrial permeability transition pore (MPtP) opening in isolated Ca 2+ -loaded rat heart mitochondria (RHM). The use of the fluorescent calcium indicator Fura 2 aM showed that tl + induced calcium influx across the plasmatic membrane, resulting in calcium ([Ca 2+ ] i ) increase in the cytoplasm. this increase was even more pronounced in experiments with accelerating of tl + -transmembrane fluxes by nonactin. It was nevertheless abolished by the removal of extracellular Ca 2+ ions, but was not inhibited by a calcium-channel blocker (nifedipine). tl + did not release calcium from the intracellular stores. tl + potentiated sodium permeability of the IMM because swelling of nonenergized rhM in medium containing tlNo 3 and NaNo 3 was enhanced at high tl + concentration. the calcium load of rhM induced MPtP opening which was accompanied by the increase of the swelling as well as the decrease of the inner membrane potential and of state 4 0 (basal) and state 3U DNP (2,4-dinitrophenol-uncoupled) respiration. These effects of Tl + were suppressed by MPtP inhibitors (cyclosporine a, aDP and n-ethylmaleimide). the data obtained showed that tl + -stimulated influx of extracellular calcium into cardiomyocytes could cause calcium and sodium rhM overload, which lead to the MPtP opening, thus determining the sensitivity of heart muscle to thallium intoxication. K e y w o r d s: tl + , Ca 2+ , Na + , cardiomyocytes, rat heart mitochondria, mitochondrial permeability transition pore (MPtP).

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Section: Resultsmentioning

confidence: 68%

Influence of Tl(+) on the Ca(2+) and Na(+) movement across rat neonatal cardiomyocytes and rat heart mitochondria membranes

et al. 2020

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“…Schwartz and Jones [14]reported that in 13% of their patients 67 Ga revealed previously unknown, nonpulmonary, occult foci of the disease. Nadel [15]reported a sensitivity of 100% in imaging sarcomas with 201 Tl, but added that the sensitivity of 201 Tl was not relative to the specificity observed; false-positive findings may present in a large variety of other states of disease ranging from histocytosis X and benign osseous tumors to stress fractures and sites of inflammation.…”

Section: Discussionmentioning

confidence: 99%

Scintigraphic Imaging of Sarcomatous Tumors with [<sup>111</sup>In-DTPA-Phe-1]-Octreotide

Giannakenas

Kalofonos²,

Apostolopoulos

et al. 2000

Oncology

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The objective of the present study was to investigate the efficacy of ¹¹¹In-DTPA-octreotide (OC) for in vivo scintigraphic imaging of these relatively uncommon tumors. Thirteen patients (9 males, 4 females, mean age 59 years) with known sarcomatous lesions were studied. All patients had known lesions as demonstrated by previous investigation with other modalities, e.g. CAT, MRI. Following intravenous injection of 10 μg of OC labeled with 2.8–4.2 mCi ¹¹¹In, planar imaging was done at 6 ± 1 and 22 ± 2 h, respectively. Histologic verification was obtained in all cases, either from fine needle aspiration or from surgically removed tissue. Positive imaging was observed in 12/13 cases (92.3%). One scan was false-negative (7.7%). Occult lesions were demonstrated in two patients. The histologic typing and the scintigraphy results were: fibrosarcoma (1+/1), embryonic rhabdomyosarcoma (1+/1), leiomyosarcomas (3+/3), liposarcomas (2+/2), uterine sarcomas (2+/2), HIV (–) Kaposi sarcoma (1+/1), osteosarcoma (1+/1), chondrosarcoma (1–/1) and neurogenous sarcoma (1+/1). OC appears to have properties that lead to a new indication for its use. Other possible applications relate to the therapeutic use of octreotide either unlabeled or labeled with a beta-emitting radionuclide, as well as its use in radioimmunoguided surgery. Regarding the latter, our preliminary results are encouraging.

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“…Thallium-201 and sestamibi are being used to assess tumor histologic response in pediatric tumors including primary bone tumors such as osteogenic sarcoma and Ewing's sarcoma, head and heck tumors, soft tissue tumors including rhabdomyosarcoma, and lymphoma [64,[66][67][68]. Thallium and sestamibi are both accumulated in viable tumor and not appreciably in necrotic tissue [69,70].…”

Section: Thallium and Sestamibimentioning

confidence: 99%

Where are we with nuclear medicine in pediatrics?

Nadel

1995

Eur J Nucl Med

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The practice of nuclear medicine in children is different from that in adults. Technical considerations including immobilization, dosing of radiopharmaceuticals, and instrumentation are of major importance. Image magnification and the capability to perform single-photon emission tomography are essential to performing state of the art pediatric nuclear medicine. New advances in instrumentation with multiple detector imaging, the possibility of clinical positron emission tomography imaging in children, and new radiopharmaceuticals will further enhance pediatric scintigraphic imaging. This review highlights advances in pediatric nuclear medicine and discusses selected clinical problems.

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Thallium-201 for oncological imaging in children

Cited by 39 publications

References 34 publications

Influence of Tl(+) on the Ca(2+) and Na(+) movement across rat neonatal cardiomyocytes and rat heart mitochondria membranes

Influence of Tl(+) on the Ca(2+) and Na(+) movement across rat neonatal cardiomyocytes and rat heart mitochondria membranes

Scintigraphic Imaging of Sarcomatous Tumors with [<sup>111</sup>In-DTPA-Phe-1]-Octreotide

Where are we with nuclear medicine in pediatrics?

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